Results 41 to 50 of about 2,269 (179)
Computational and Structural Biotechnology Journal, 2020 G protein-gated inwardly rectifying potassium channels (GIRK) are essential for the regulation of cellular excitability, a physiological function that relies critically on the conduction of K+ ions, which is dependent on two molecular mechanisms, namely ...
Dai-Lin Li +3 more
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Frontiers in Behavioral Neuroscience, 2021 Pathological impairments in the regulation of affect (i.e., emotion) and flexible decision-making are commonly observed across numerous neuropsychiatric disorders and are thought to reflect dysfunction of cortical and subcortical circuits that arise in ...
Eden M. Anderson +4 more
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The role of inhibitory G proteins and regulators of G protein signaling in the in vivo control of heart rate and predisposition to cardiac arrhythmias [PDF]
, 2012 Inhibitory heterotrimeric G proteins and the control of heart rate. The activation of cell signaling pathways involving inhibitory heterotrimeric G proteins acts to slow the heart rate via modulation of ion channels.
Ang, R, Opel, A, Tinker, A
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Structural rearrangements underlying ligand-gating in Kir channels [PDF]
, 2012 Inward rectifier potassium (Kir) channels are physiologically regulated by a wide range of ligands that all act on a common gate, although structural details of gating are unclear.
Enkvetchakul, Decha +4 more
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Cell Reports, 2018 Summary: Inhibition provided by local GABAergic interneurons (INs) activates ionotropic GABAA and metabotropic GABAB receptors (GABABRs). Despite GABABRs representing a major source of inhibition, little is known of their function in distinct IN subtypes.
Sam A. Booker +7 more
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Pregnenolone sulfate potentiates the inwardly rectifying K channel Kir2.3. [PDF]
PLoS ONE, 2009 BACKGROUND:Neurosteroids have various physiological and neuropsychopharmacological effects. In addition to the genomic effects of steroids, some neurosteroids modulate several neurotransmitter receptors and channels, such as N-methyl-D-aspartate ...
Toru Kobayashi +2 more
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Frontiers in Physiology, 2018 Diminished parasympathetic influence is central to the pathogenesis of cardiovascular diseases, including heart failure and hypertension. Stimulation of the vagus nerve has shown promise in treating cardiovascular disease, prompting renewed interest in ...
Steven W. Lee +5 more
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The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels [PDF]
Channels, 2010 Kir3 channels (also known as GIRK channels) are important regulators of electrical excitability in both cardiomyocytes and neurons. Much is known regarding the assembly and function of these channels and the roles that their interacting proteins play in controlling these events.
Peter, Zylbergold +2 more
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Frontiers in Neuroscience, 2017 Alzheimer's disease is characterized by cognitive decline, neuronal degeneration, and the accumulation of amyloid-beta (Aβ). Although, the neurotoxic Aβ peptide is widely believed to trigger neuronal dysfunction and degeneration in Alzheimer's disease ...
Linda M. May +14 more
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Action potentials in primary osteoblasts and in the MG-63 osteoblast-like cell line [PDF]
, 2011 Whole-cell patch-clamp analysis revealed a resting membrane potential of −60 mV in primary osteoblasts and in the MG-63 osteoblast-like cells. Depolarization-induced action potentials were characterized by duration of 60 ms, a minimal peak-to-peak ...
Begandt, Daniela +7 more
core +2 more sources