Results 51 to 60 of about 2,269 (179)

N-terminal Tyrosine Residues within the Potassium Channel Kir3 Modulate GTPase Activity of Gαi [PDF]

Journal of Biological Chemistry, 2002
trkB activation results in tyrosine phosphorylation of N-terminal Kir3 residues, decreasing channel activation. To determine the mechanism of this effect, we reconstituted Kir3, trkB, and the mu opioid receptor in Xenopus oocytes. Activation of trkB by BDNF (brain-derived neurotrophic factor) accelerated Kir3 deactivation following termination of mu ...
Danielle L, Ippolito, Paul A, Temkin, Sherri L, Rogalski, Charles, Chavkin   +3 more
openaire   +2 more sources

Kv7.4 Channel Contribute to Projection-Specific Auto-Inhibition of Dopamine Neurons in the Ventral Tegmental Area

Frontiers in Cellular Neuroscience, 2019
Dopaminergic neurons in the ventral tegmental area (VTA) encode behavioral patterns important in reward and drug addiction as well as in emotional disorders.
Min Su, Min Su, Min Su, Li Li, Li Li, Li Li, Jing Wang, Jing Wang, Jing Wang, Jing Wang, Hui Sun, Hui Sun, Hui Sun, Ludi Zhang, Ludi Zhang, Ludi Zhang, Chen Zhao, Chen Zhao, Chen Zhao, Ying Xie, Nikita Gamper, Nikita Gamper, Nikita Gamper, Nikita Gamper, Xiaona Du, Xiaona Du, Xiaona Du, Hailin Zhang, Hailin Zhang, Hailin Zhang   +29 more
doaj   +1 more source

Tyrosine Phosphorylation of Kir3 following κ-Opioid Receptor Activation of p38 MAPK Causes Heterologous Desensitization [PDF]

Journal of Biological Chemistry, 2009
Prior studies showed that tyrosine 12 phosphorylation in the N-terminal, cytoplasmic domain of the G-protein-gated inwardly rectifying potassium channel, K(ir)3.1 facilitates channel deactivation by increasing intrinsic GTPase activity of the channel.
Cecilea C, Clayton, Mei, Xu, Charles, Chavkin   +2 more
openaire   +2 more sources

Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice

Alzheimer’s Research & Therapy, 2022
Alzheimer’s disease (AD) is characterized by a reorganization of brain activity determining network hyperexcitability and loss of synaptic plasticity.
Alejandro Martín-Belmonte, Carolina Aguado, Rocío Alfaro-Ruiz, Ana Esther Moreno-Martínez, Luis de la Ossa, Ester Aso, Laura Gómez-Acero, Ryuichi Shigemoto, Yugo Fukazawa, Francisco Ciruela, Rafael Luján   +10 more
doaj   +1 more source

HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes [PDF]

, 2010
An inwardly rectifying K^+ current is present in atrial cardiac myocytes that is activated by acetylcholine (I_{KACh}). Physiologically, activation of the current in the SA node is important in slowing the heart rate with increased parasympathetic tone ...
A Benians, A Benians, A Benians, A Noma, AM Tolkovsky, Andrew Tinker, C Cifelli, C Marionneau, CE Ford, CL Huang, D Dobrev, D Dobrev, EN Nikolov, G Krapivinsky, I Riven, I Savelieva, J Gehrmann, JB Blumer, JL Leaney, JL Leaney, K Hu, K Wickman, L Sartiani, LC Mace, M Baruscotti, M Bechem, M Nobles, M Xia, M Yamada, MC Wellner-Kienitz, MD Drici, Muriel Nobles, N Lavine, N Voigt, O Wiser, Q Zhang, RB Robinson, S Fujita, S Peleg, SM Clancy, SM White, Sonia Sebastian, WA Boyle, WC Claycomb, Z Zuberi   +44 more
core   +2 more sources

The cationic region of Rhes mediates its interactions with specific Gβ subunits [PDF]

, 2009
Ras homologue enriched in striatum (Rhes) is a small monomeric G protein which functions in a variety of cellular processes, including attenuation of G protein-coupled receptor (GPCR)signalling.
Davey, John, Goddard, Alan, Hill, Claire, Ladds, Graham   +3 more
core   +2 more sources

G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury

Journal of Pain Research, 2020
Chuang Lyu,1 Gong-Wei Lyu,2 Jan Mulder,3,4 Aurora Martinez,5 Tie-Jun Sten Shi5 1State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150069, People’s Republic of ...
Lyu C, Lyu GW, Mulder J, Martinez A, Shi TJS   +4 more
doaj  

Secondary anionic phospholipid binding site and gating mechanism in Kir2.1 inward rectifier channels [PDF]

, 2013
Inwardly rectifying potassium (Kir) channels regulate multiple tissues. All Kir channels require interaction of phosphatidyl-4,5-bisphosphate (PIP(2)) at a crystallographically identified binding site, but an additional nonspecific secondary anionic ...
Borschel, William, Gyore, Jacob, Heyman, Sarah, Lee, Sun-Joo, Nichols, Colin G, Wang, Shizhen   +5 more
core   +2 more sources

Opioid Receptors in Immune and Glial Cells-Implications for Pain Control [PDF]

, 2020
Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Celik, Melih Ö., Machelska, Halina
core   +1 more source

Intensity limits of the PSI Injector II cyclotron

, 2017
We investigate limits on the current of the PSI Injector II high intensity separate-sector isochronous cyclotron, in its present configuration and after a proposed upgrade.
A. Adelmann, A. Kolano, Adam, Adam, Allen, Baumgarten, C. Baumgarten, Kolano, Landau, Qiang, R. Barlow, Stammbach, Toggweiler, Wangler   +13 more
core   +1 more source