Results 181 to 190 of about 2,276,672 (229)

The involvement of K⁺ channels in depression and pharmacological effects of antidepressants on these channels. [PDF]

Transl Psychiatry
Li XT.
europepmc   +1 more source

The physiological characteristics of inward rectifying potassium channel Kir4.2 and its research progress in human diseases. [PDF]

Front Cell Dev Biol
Zhang H, Bai Z, Xi Y.
europepmc   +1 more source

The role of dystrophin isoforms and interactors in the brain. [PDF]

Brain
Tetorou K, Aghaeipour A, Singh S, Morgan JE, Muntoni F.   +4 more
europepmc   +1 more source

Altered synaptic homeostasis: a key factor in the pathophysiology of depression. [PDF]

Cell Biosci
Wang B, He T, Qiu G, Li C, Xue S, Zheng Y, Wang T, Xia Y, Yao L, Yan J, Chen Y.   +10 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

High-potency block of Kir4.1 channels by pentamidine: Molecular basis

European Journal of Pharmacology, 2017
Inward rectifier potassium (Kir) channels are expressed in almost all mammalian tissues and contribute to a wide range of physiological processes. Kir4.1 channel expression is found in the brain, inner ear, eye, and kidney. Loss-of-function mutations in the pore-forming Kir4.1 subunit cause an autosomal recessive disorder characterized by epilepsy ...
Aréchiga-Figueroa, Iván A, Marmolejo-Murillo, Leticia G, Cui, Meng, Delgado-Ramírez, Mayra, van der Heyden, Marcel A G, Sánchez-Chapula, José A, Rodríguez-Menchaca, Aldo A   +6 more
openaire   +4 more sources

Chloroquine blocks the Kir4.1 channels by an open-pore blocking mechanism

European Journal of Pharmacology, 2017
Kir4.1 channels have been implicated in various physiological processes, mainly in the K+ homeostasis of the central nervous system and in the control of glial function and neuronal excitability. Even though, pharmacological research of these channels is very limited.
Leticia G, Marmolejo-Murillo, Iván A, Aréchiga-Figueroa, Eloy G, Moreno-Galindo, Ricardo A, Navarro-Polanco, Aldo A, Rodríguez-Menchaca, Meng, Cui, José A, Sánchez-Chapula, Tania, Ferrer   +7 more
openaire   +3 more sources

Inhibition of astroglial Kir4.1 channels by selective serotonin reuptake inhibitors

Brain Research, 2007
The inwardly rectifying K+ (Kir) channel Kir4.1 is responsible for astroglial K+ buffering. We recently found that tricyclic antidepressants (TCAs) inhibit Kir4.1 channel currents, which suggests that astroglial Kir currents might be involved in the pharmacological action of antidepressants.
Yukihiro, Ohno, Hiroshi, Hibino, Christoph, Lossin, Atsushi, Inanobe, Yoshihisa, Kurachi   +4 more
openaire   +3 more sources

Inhibition of Astroglial Inwardly Rectifying Kir4.1 Channels by a Tricyclic Antidepressant, Nortriptyline

The Journal of Pharmacology and Experimental Therapeutics, 2007
The inwardly rectifying K(+) (Kir) channel Kir4.1 is responsible for astroglial K(+) buffering. We examined the effects of nortriptyline, a tricyclic antidepressant (TCA), on Kir4.1 channel currents heterologously expressed in HEK293T cells, using a whole-cell patch-clamp technique. Nortriptyline (3-300 microM) reversibly inhibited Kir4.1 currents in a
Suwen, Su, Yukihiro, Ohno, Christoph, Lossin, Hiroshi, Hibino, Atsushi, Inanobe, Yoshihisa, Kurachi   +5 more
openaire   +3 more sources

Molecular determinants for the distinct pH sensitivity of Kir1.1 and Kir4.1 channels

American Journal of Physiology-Cell Physiology, 2000
Kir1.1 (ROMK1) is inhibited by hypercapnia and intracellular acidosis with midpoint pH for channel inhibition (p K a) of ∼6.7. Another close relative, Kir4.1 (BIR10), is also pH sensitive with much lower pH sensitivity (p K a ∼6.0), although it shares a high sequence homology with Kir1.1.
H, Xu, Z, Yang, N, Cui, L R, Giwa, L, Abdulkadir, M, Patel, P, Sharma, G, Shan, W, Shen, C, Jiang   +9 more
openaire   +3 more sources

Expressional analysis of inwardly rectifying Kir4.1 channels in Noda epileptic rat (NER)

Brain Research, 2013
The inwardly rectifying potassium channel subunit Kir4.1 is expressed in brain astrocytes and involved in spatial K(+) buffering, regulating neural activity. To explore the pathophysiological alterations of Kir4.1 channels in epileptic disorders, we analyzed interictal expressional levels of Kir4.1 in the Noda epileptic rat (NER), a hereditary animal ...
Yuya, Harada, Yuki, Nagao, Saki, Shimizu, Tadao, Serikawa, Ryo, Terada, Megumi, Fujimoto, Aoi, Okuda, Takahiro, Mukai, Masashi, Sasa, Yoshihisa, Kurachi, Yukihiro, Ohno   +10 more
openaire   +3 more sources