Biological Significance of Kisspeptin–Kiss 1 Receptor Signaling in the Habenula of Teleost Species
Frontiers in Endocrinology, 2018 Kisspeptin is a neuropeptide, encoded by kisspeptin 1 (KISS1)/Kiss1 gene, which primarily acts as the regulator of reproductive functions via its receptor, kisspeptin receptor (KissR) in vertebrates.
Satoshi Ogawa, Ishwar S. Parhar
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Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man. [PDF]
, 2012 Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in
Bloom, Stephen R. +11 more
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Kisspeptin as a Behavioral Hormone
Seminars in Reproductive Medicine, 2019 AbstractSuccessful reproduction is dependent not only on hormonal endocrine responses but also on suitable partner selection, copulatory acts, as well as associated emotional, behavioral, and cognitive processes many of which are supported by the limbic system.
Edouard Mills +3 more
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Distribution and regulation of gonadotropin-releasing hormone, kisspeptin, RF-amide related peptide-3, and dynorphin in the bovine hypothalamus [PDF]
PeerJ, 2016 Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the arcuate nucleus (ARC) play a key role in gonadotropin-releasing hormone (GnRH) pulse generation and gonadal steroid feedback, with kisspeptin driving GnRH ...
Valeria M. Tanco +5 more
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Kisspeptin: Beyond the Brain [PDF]
Endocrinology, 2015 The hypothalamic-based kisspeptin-signaling system is a major positive regulator of the neuroendocrine-reproductive axis in mammals. During the last decade, major advances have been made in understanding how this signaling system is regulated and how it can be manipulated clinically to achieve beneficial outcomes in treating sex steroid-dependent ...
Andy V. Babwah, Moshmi Bhattacharya
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Frontiers in EndocrinologyBackgroundKisspeptin has been indicated to be a biomarker of fetal growth. Although some evidence suggested that maternal kisspeptin concentrations in early pregnancy were associated with increased fetal growth, studies are still limited and the effect ...
Jiaxian Chen +8 more
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Effects of Selective Deletion of Tyrosine Hydroxylase from Kisspeptin Cells on Puberty and Reproduction in Male and Female Mice. [PDF]
, 2017 The neuropeptide kisspeptin, encoded by Kiss1, regulates reproduction by stimulating GnRH secretion. Kiss1-syntheizing neurons reside primarily in the hypothalamic anteroventral periventricular (AVPV/PeN) and arcuate (ARC) nuclei.
Chahal, Navi +6 more
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Substance P regulates puberty onset and fertility in the female mouse [PDF]
, 2015 Puberty is a tightly regulated process that leads to reproductive capacity. Kiss1 neurons are crucial in this process by stimulating GnRH, yet how Kiss1 neurons are regulated remains unknown. Substance P (SP), an important neuropeptide in pain perception,
Carroll, R.S. +7 more
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Serum kisspeptin levels mainly depend on ovarian expression of Kiss1 mRNA in female rats
Frontiers in Physiology, 2022 The hypothalamic kisspeptin/KISS1 receptor system is essential for puberty onset and reproductive development. Although serum kisspeptin might be associated with puberty, its levels, according to developmental stage, and its origin still remain unclear ...
Ahreum Kwon +7 more
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The "ram effect": new insights into neural modulation of the gonadotropic axis by male odors and socio-sexual interactions [PDF]
, 2015 Reproduction in mammals is controlled by the hypothalamo-pituitary-gonadal (HPG) axis under the influence of external and internal factors such as photoperiod, stress, nutrition, and social interactions.
Abbott +151 more
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