Results 51 to 60 of about 283,825 (337)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Isolation and Characterization of Klebsiella Phages for Phage Therapy

PHAGE, 2021
Introduction: Klebsiella is a clinically important pathogen causing a variety of antimicrobial resistant infections in both community and nosocomial settings, particularly pneumonia, urinary tract infection, and sepsis.
Eleanor Townsend, Lucy Kelly, Lucy Gannon, George Muscatt, R. Dunstan, Slawomir Michniewski, Hari Sapkota, S. Kiljunen, Anna Kolsi, M. Skurnik, T. Lithgow, A. Millard, E. Jameson   +12 more
semanticscholar   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Antibiotic resistance pattern of Klebsiella pneumoniae in obtained samples from Ziaee Hospital of Ardakan, Yazd, Iran during 2016 to 2017

Iberoamerican Journal of Medicine, 2020
Background: In recent years, due to the inappropriate use of antibiotics, drug resistance has increased in gram negative bacilli, including Klebsiella pneumoniae.
Jamshid Ayatollahi, Mohammad Sharifyazdi, Razieh Fadakarfard, Seyed Hossein Shahcheraghi   +3 more
doaj   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Antibiotic-loaded cement spacer for treatment of Klebsiella infected total hip and knee arthroplasty [PDF]

Vojnosanitetski Pregled, 2014
Background/Aim. Infection following total hip arthroplasty (THA) or total knee arthoplasty (TKA) may have devastating consequences. Some bacterial strains are often encountered as agents of these infections, others occur less frequently but are ...
Barjaktarović Radoslav, Radoičić Dragan, Mitković Milorad   +2 more
doaj   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Chemical Synthesis of Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii Capsular Polysaccharide Fragments as Leads for Cross‐Protection

Angewandte Chemie, EarlyView.
A total of 16 chemically synthesized capsular polysaccharide (CPS) fragments related to Pseudomonas aeruginosa, Staphylococcus aureus, and Acinetobacter baumannii were analyzed by glycan microarray. Comparative screening revealed three conserved epitopes that act as cross‐protective vaccine lead candidates against multidrug‐resistant (MDR) bacterial ...
Amar Kumar Mishra, Emelie E. Reuber, Diksha Rai, Leif E. Sander, Julia Duerr, Simon Y. Graeber, Marcus A. Mall, Bettina C. Fries, Peter H. Seeberger, Suvarn S. Kulkarni   +9 more
wiley   +2 more sources

Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance: A Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2018
Importance Extended-spectrum &bgr;-lactamases mediate resistance to third-generation cephalosporins (eg, ceftriaxone) in Escherichia coli and Klebsiella pneumoniae.
P. Harris, P. Tambyah, D. Lye, Y. Mo, Tau-Hong Lee, M. Yılmaz, T. Alenazi, Y. Arabi, M. Falcone, M. Bassetti, E. Righi, B. Rogers, S. Kanj, H. Bhally, J. Iredell, M. Mendelson, T. Boyles, D. Looke, S. Miyakis, G. Walls, Mohammed Al Khamis, A. Zikri, A. Crowe, P. Ingram, N. Daneman, P. Griffin, E. Athan, Penelope Lorenc, Peter Baker, Leah W. Roberts, S. Beatson, A. Peleg, T. Harris-Brown, D. Paterson   +33 more
semanticscholar   +1 more source

Modelling the Gastrointestinal Carriage of Klebsiella pneumoniae Infections

bioRxiv, 2022
Klebsiella pneumoniae is one of the pathogens that is sweeping the world in the antibiotic resistance pandemic. Klebsiella colonizes the nasopharynx and the gut of healthy subjects in an asymptomatic manner, making gut colonization a requisite for ...
R. Calderón-Gonzalez, Alix Lee, G. López-Campos, Steven J. Hancock, Joana Sá-Pessoa, A. Dumigan, R. McMullan, Eric L Campbell, J. Bengoechea   +8 more
semanticscholar   +1 more source