Results 221 to 230 of about 184,541 (309)

Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications

MedComm, Volume 7, Issue 2, February 2026.
The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome‐targeted intervention strategies can improve the efficacy of ICI, but necessitating more comprehensive exploration.
Anqi Lin, Minying Xiong, Aimin Jiang, Li Chen, Lihaoyun Huang, Kailai Li, Hank Z. H. Wong, Jian Zhang, Zaoqu Liu, Quan Cheng, Bufu Tang, Pengpeng Zhang, Peng Luo   +12 more
wiley   +1 more source

Sequence type and strain-level detection of <i>Klebsiella pneumoniae</i> in culture-enriched bacterial metagenomes: comparative performance of mSWEEP and StrainGE bioinformatic tools. [PDF]

Microb Genom
Buczek DJ, Kabir W, Lindstedt K, Mäklin T, Thorpe HA, Suzuki Y, Corander J, Samuelsen Ø, Sundsfjord A.   +8 more
europepmc   +1 more source

Next Generation Sequencing of Tracheal Aspirates in Children With Tracheostomy A Prospective Case‐Control Study

Pediatric Pulmonology, Volume 61, Issue 2, February 2026.
ABSTRACT Background Tracheostomies are increasingly performed in children. The treatment of infections in tracheostomized patients is challenging because of the distinction between chronic colonization and acute infection. Next‐generation sequencing (NGS) is a promising alternative for identifying and quantifying pathogens in a short period. This study
Pia Brensing, Julia Lutynski, Michael Hilder, Thorsten Brenner, Sonia Mazzitelli, Silke Grumaz, Florian Stehling   +6 more
wiley   +1 more source

Conjugative Transfer of Disease‐Encoding Plasmid Variants in Serratia spp. Alter Production of Enzymes and Virulence Properties

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
Analysis of plasmid transconjugants relative to plasmid‐free and plasmid‐carrying Serratia spp. demonstrates erratic disease phenotypes and reduced fitness. Transconjugants also show reduced ability to degrade substrates associated with virulence, supported by transcriptomic data.
Amy L. Vaughan, Travis R. Glare, Charles A. Hefer, Mark R. H. Hurst   +3 more
wiley   +1 more source

Impact of Attaining an Aggressive Pharmacokinetic-Pharmacodynamic Target on the Clinical Efficacy of Continuous Infusion β-Lactam Therapy for Early Posttransplant Gram-Negative Infections in Critically Ill Orthotopic Liver Transplant Recipients: An Interim Analysis of a 3-Year Prospective, Observational Study. [PDF]

J Infect Dis
Gatti M, Rinaldi M, Laici C, Bonazzetti C, Vizioli L, Ambretti S, Morelli MC, Siniscalchi A, Giannella M, Viale P, Pea F.   +10 more
europepmc   +1 more source

Aberrant Growth in 5‐Year‐Old Children After Antibiotics in the First Week of Life

Acta Paediatrica, Volume 115, Issue 2, Page 309-318, February 2026.
ABSTRACT Aim We examined the relationship between early‐life antibiotics, different regimens, and growth until age five years. Methods Data from two parallel birth cohorts were analysed: 128 healthy term‐born children and 147 term‐born children who received antibiotics for suspected neonatal sepsis, randomised across three regimens: Amoxicillin ...
Lisanne M. van Leeuwen, Gina J. van Beveren, Marieke A. G. Peeters, Dennis Souverein, Sjoerd Euser, Debby Bogaert, Marlies A. van Houten   +6 more
wiley   +1 more source

Alterations in Gut Microbiota and Metabolism in Cirrhotic Portal Hypertension: Implications for Disease Progression

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 4, Page 538-556, February 2026.
In‐depth multiomics analyses revealed that the gut microbiota in patients with CPH is dysbiotic. Altered gut microbiota plays an important role in the progression of CPH and affects the host's arginine metabolism to promote arginine biosynthesis. The pro‐inflammatory effects of certain gut bacteria induce iNOS expression, which together act on the ...
Qun Zhang, Jinghua Cui, Yixin Hou, Lining Guo, Hai Li, Guiqin Zhou, Xiaojing Wang, Bingbing Zhu, Ke Shi, Yi Zhang, Yufei Bi, Yanqiu Li, Lina Sun, Ying Feng, Jing Yuan, Xianbo Wang   +15 more
wiley   +1 more source

Predictors of 30-day mortality in critically ill patients with bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: a five-year retrospective study. [PDF]

BMC Infect Dis
Teo MY, Leu SW, Chiu LC, Chang KW, Wu BC, Chuang LP, Lin SW, Hsieh MJ, Wu HP, Kao KC, Hu HC.   +10 more
europepmc   +1 more source

PIONEER REAL Saudi Arabia: A multicentre, prospective, real‐world study of once‐daily oral semaglutide use in adults with type 2 diabetes in Saudi Arabia

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1304-1314, February 2026.
Abstract Aim PIONEER REAL Saudi Arabia investigated real‐world clinical outcomes associated with the use of once‐daily oral semaglutide in adults with type 2 diabetes (T2D). Materials and Methods This was a 34‐ to 44‐week multicentre, prospective, open‐label study in adults with T2D, who were treatment‐naive to injectable glucose‐lowering medication ...
Hussein ElBadawi, Nader Albalkhi, Ibrahim Al Kadhim, Ahmed Elsadig, Dimitrios Baltzis, Mohamed Hassan Hatahet, Mahmoud Ismail, Said Khader, Christina Louise Rasmussen, Stine Hedegaard Scheuer, Ahmed Shalaby, Mohammed Almehthel   +11 more
wiley   +1 more source

Development of Metagenomic Methods for Health Monitoring of Endangered Species Using Fecal Samples

Evolutionary Applications, Volume 19, Issue 2, February 2026.
ABSTRACT Metagenomic analysis of fecal samples is emerging as a powerful tool for monitoring endangered species, particularly in assessing the burden of pathogens and parasites that can threaten population viability. However, accurate identification in non‐model species remains challenging due to the frequent absence of host‐specific pathogen reference
Román Sapino, Ángel Fernández‐González, Jose Castresana   +2 more
wiley   +1 more source