Results 41 to 50 of about 55,031 (288)
Co-expression networks in generation of induced pluripotent stem cells. [PDF]
, 2016 We developed an adenoviral vector, in which Yamanaka's four reprogramming factors (RFs) were controlled by individual CMV promoters in a single cassette (Ad-SOcMK). This permitted coordinated expression of RFs (SOX2, OCT3/4, c-MYC and KLF4) in a cell for
Coppola, Giovanni +6 more
core +2 more sources
KLF4 Nuclear Export Requires ERK Activation and Initiates Exit from Naive Pluripotency
Stem Cell Reports, 2018 Summary: Cooperative action of a transcription factor complex containing OCT4, SOX2, NANOG, and KLF4 maintains the naive pluripotent state; however, less is known about the mechanisms that disrupt this complex, initiating exit from pluripotency.
Navroop K. Dhaliwal +4 more
doaj +1 more source
Upregulation of the constitutively expressed HSC70 by KLF4 [PDF]
Cell Stress and Chaperones, 2008 Krüppel-like factor 4 (KLF4) is a transcription factor that is abundantly expressed in various organisms from bacteria to mammals. It has been demonstrated that KLF4 regulates the expression of a wide range of genes. Analysis of KLF4 target genes reveals its diverse regulatory functions in cell growth, proliferation, differentiation, embryogenesis, and
Ying, Liu +5 more
openaire +2 more sources
Kruppel-Like Factor 4 Regulates Granule Cell Pax6 Expression and Cell Proliferation in Early Cerebellar Development. [PDF]
PLoS ONE, 2015 Kruppel-like factor 4 (Klf4) is a transcription factor that regulates many important cellular processes in stem cell biology, cancer, and development. We used histological and molecular methods to study the expression of Klf4 in embryonic development of ...
Peter Zhang +4 more
doaj +1 more source
Induction of KLF4 in response to heat stress [PDF]
Cell Stress & Chaperones, 2006 Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor with diverse regulatory functions in cell growth, proliferation, differentiation, and embryogenesis. However, little is known about the response of KLF4 to heat stress.
Ying, Liu +9 more
openaire +2 more sources
Journal of Inflammation Research, 2021 Zhenjun Xu,1,* Kai Zhong,2,* Guanjun Guo,1,* Can Xu,1 Zhizhao Song,1 Dongjin Wang,1 Jun Pan1 1Department of Thoracic and Cardiovascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School ...
Xu Z +6 more
doaj
Translational Oncology, 2022 Background: Non-small cell lung cancer (NSCLC) remains an aggresive tumor with poor survival rates. Krüppel-like factor 4 (KLF4) is known to be involved in progression of NSCLC; however, the detailed mechanism by which KLF4 regulates the progression of ...
Di-Di Luo, Feng Zhao
doaj +1 more source
Cooperative Transcriptional Activation by Klf4, Meis2, and Pbx1 [PDF]
Molecular and Cellular Biology, 2011 The Kruppel-like factor Klf4 is implicated in tumorigenesis and maintaining stem cell pluripotency, and Klf4 can both activate and repress gene expression. We show that the Pbx1 and Meis2 homeodomain proteins interact with Klf4 and can be recruited to DNA elements comprising a Klf4 site or GC box, with adjacent Meis and Pbx sites.
Glen A, Bjerke +2 more
openaire +2 more sources
Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]
, 2017 Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J +15 more
core +4 more sources
Biotechnology & Biotechnological Equipment, 2019 Melatonin (MEL) may influence the efficiency of reprogramming both by somatic cell nuclear transfer and by direct induction of pluripotent stem cells (iPSC) through a yet unidentified mechanism. Transcription factors linked to cell reprogramming and cell
Georgi Nikolaev Georgiev +3 more
doaj +1 more source