Results 51 to 60 of about 55,031 (288)
PLoS ONE, 2014 The role of different lineage specific transcription factors in directing hematopoietic cell fate towards myeloid lineage is well established but the status of epigenetic modifications has not been defined during this important developmental process.
Manjula Karpurapu +9 more
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Attenuation of krüppel-like factor 4 facilitates carcinogenesis by inducing g1/s phase arrest in clear cell renal cell carcinoma. [PDF]
PLoS ONE, 2013 Krüppel-like factor 4 (KLF4) is a transcription factor with diverse functions in various cancer types; however, the function of KLF4 in clear cell renal cell carcinoma (ccRCC) carcinogenesis remains unknown.
Erlin Song +13 more
doaj +1 more source
Structural basis for Klf4 recognition of methylated DNA [PDF]
Nucleic Acids Research, 2014 Transcription factor Krüppel-like factor 4 (Klf4), one of the factors directing cellular reprogramming, recognizes the CpG dinucleotide (whether methylated or unmodified) within a specific G/C-rich sequence. The binding affinity of the mouse Klf4 DNA-binding domain for methylated DNA is only slightly stronger than that for an unmodified oligonucleotide.
Liu, Yiwei +6 more
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The Tumor Suppressor HHEX Inhibits Axon Growth when Prematurely Expressed in Developing Central Nervous System Neurons [PDF]
, 2015 Neurons in the embryonic and peripheral nervoussystem respond to injury by activating transcriptional programs supportive of axon growth, ultimately resulting in functional recovery.
Blackmore, Murray G. +9 more
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Regulation of EMT by KLF4 in Gastrointestinal Cancer [PDF]
Current Cancer Drug Targets, 2013 Gastrointestinal (GI) cancer is characterized by its aggressiveness, but the underlying mechanism is not fully understood. Studies reveal that epithelial to mesenchymal transition (EMT), which is regulated by a series of transcription factors and signaling pathways, is strongly associated with GI cancer cell proliferation, invasion and metastasis ...
Jiujie, Cui +3 more
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Direct comparison of distinct naive pluripotent states in human embryonic stem cells [PDF]
, 2017 Until recently, human embryonic stem cells (hESCs) were shown to exist in a state of primed pluripotency, while mouse embryonic stem cells (mESCs) display a naive or primed pluripotent state.
Chuva de Sousa Lopes, Susana Marina +18 more
core +1 more source
Meningioma: current updates on genetics, classification, and mouse modeling
Upsala Journal of Medical SciencesMeningiomas, the most common primary brain tumors in adults, are often benign and curable by surgical resection. However, a subset is of higher grade, shows aggressive growth behavior as well as brain invasion, and often recurs even after several rounds ...
Frank Szulzewsky +2 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Krüppel-like factor 4 (KLF4), a member of the KLF family of zinc finger transcription factors, has been identified as a tumor suppressor gene in a variety of tumors.
Zhonglin Zhu +8 more
doaj +1 more source
Role of Klf4 in the Regulation of Apoptosis and Cell Cycle in Rat Granulosa Cells during the Periovulatory Period [PDF]
, 2019 In the ovary, the luteinizing hormone (LH) surge suppresses the proliferation and induces the luteinization of preovulatory granulosa cells (GCs), which is crucial for the survival of terminally-differentiated GCs.
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core +1 more source
Cross-talk between KLF4 and STAT3 regulates axon regeneration [PDF]
Nature Communications, 2013 Cytokine-induced activation of signal transducer and activator of transcription 3 (STAT3) promotes the regrowth of damaged axons in the adult central nervous system (CNS). Here we show that KLF4 physically interacts with STAT3 upon cytokine-induced phosphorylation of tyrosine 705 (Y705) on STAT3.
Qin, Song, Zou, Yuhua, Zhang, Chun-Li
openaire +2 more sources