Results 111 to 120 of about 33,787 (326)
Frontiers in Endocrinology, 2023 Background The potential relationship between Klotho and cognitive function is limited and controversial. This study aimed to quantify the association of Klotho and cognitive impairment in chronic kidney disease (CKD) patients with albuminuria.
Jialing Zhang, A. Zhang
semanticscholar +1 more source
Alpha Klotho and phosphate homeostasis [PDF]
Journal of Endocrinological Investigation, 2014 The Klotho family consists of three single-pass transmembrane proteins—αKlotho, βKlotho and γKlotho. Each of them combines with fibroblast growth factor (FGF) receptors (FGFRs) to form receptor complexes for various FGF’s. αKlotho is a co-receptor for physiological FGF23 signaling and appears essential for FGF23-mediated regulation of mineral ...
A, Bian, C, Xing, M C, Hu
openaire +2 more sources
A protective role for FGF-23 in local defence against disrupted arterial wall integrity? [PDF]
, 2013 Increasing interest is focusing on the role of the FGF-23/Klotho axis in mediating vascular calcification. However, the underpinning mechanisms have yet to be fully elucidated. Murine VSMCs were cultured in calcifying medium for a 21d period. FGF-23 mRNA
Ben-Dov +57 more
core +1 more source
Soluble Klotho protects against glomerular injury through regulation of ER stress response
Communications Biology, 2023 αKlotho (Klotho) has well established renoprotective effects; however, the molecular pathways mediating its glomerular protection remain incompletely understood.
Emmanuelle Charrin +9 more
semanticscholar +1 more source
Klotho and Chronic Kidney Disease [PDF]
, 2013 Through alternative splicing, Klotho protein exists both as a secreted and a membrane form whose extracellular domain could be shed from the cell surface by secretases and released into the circulation to act as endocrine factor. Unlike membrane Klotho which functions as a coreceptor for fibroblast growth factor-23 (FGF23) to modulate FGF23 signal ...
Ming Chang, Hu +2 more
openaire +2 more sources
Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy
Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley +1 more source
Journal of Hematology & Oncology, 2017 Background Klotho, is a transmembrane protein, performs as a circulating hormone and upstream modulator of the insulin-like growth factor-1 receptor (IGF-1R), fibroblast growth factor (FGF), and Wnt signaling pathways.
Xiangxiang Zhou +9 more
doaj +1 more source
Abstract #1595981: Changes in Fibroblast Growth Factor-23 and the Klotho Protein Axis in Diabetic Nephropathy [PDF]
, 2023 Nozimakhon Nazarova +7 more
openalex +1 more source
Journal of Ovarian Research, 2023 Background Many epidemiological studies have shown that anovulatory polycystic ovary syndrome (PCOS) is accompanied by hyperandrogenism. However, the exact mechanism of hyperandrogen-induced anovulation remains to be elucidated.
Xin Zeng +6 more
semanticscholar +1 more source
Klotho Prevents Renal Calcium Loss [PDF]
Journal of the American Society of Nephrology, 2009 Disturbed calcium (Ca(2+)) homeostasis, which is implicit to the aging phenotype of klotho-deficient mice, has been attributed to altered vitamin D metabolism, but alternative possibilities exist. We hypothesized that failed tubular Ca(2+) absorption is primary, which causes increased urinary Ca(2+) excretion, leading to elevated 1,25-dihydroxyvitamin ...
Alexander, R.T. +7 more
openaire +3 more sources