Results 151 to 160 of about 33,787 (326)
Di-san junyi daxue xuebao, 2020 Objective To investigate the association of serum klotho level with renal function deterioration and whether serum klotho level can be used as a predictor of progression of chronic kidney disease (CKD) into renal end point events.
YANG Jiangxin +3 more
doaj +1 more source
Lifestyle and Behavioural Intervention Therapy for Enhanced Hippocampal Neuroplasticity
Lifestyle Medicine, Volume 7, Issue 1, January 2026.ABSTRACT Background The neurogenic and neuroplastic capability of the brain plays a crucial role in mitigating responses to internal and external environmental stimuli. However, this process is inhibited in obesity, neurodegenerative and psychological disorders, the prevalence of which has increased on a global scale.
Ebrahim Samodien +4 more
wiley +1 more source
Hyperaldosteronism in Klotho-deficient mice
American Journal of Physiology-Renal Physiology, 2010 Klotho is a membrane protein participating in the inhibitory effect of FGF23 on the formation of 1,25-dihydroxyvitamin-D 3 [1,25(OH) 2 D 3 ].
Fischer, Stephanie S. +11 more
openaire +4 more sources
Pregnancy, Volume 2, Issue 1, January 2026.Abstract Introduction Sedentary (SED) behavior is highly prevalent during pregnancy and is linked to negative maternal and fetal metabolic outcomes, even independent of weight gain and obesity. While emerging evidence suggests that increased maternal physical activity can counteract the detrimental effects of maternal SED behavior on offspring ...
Danielle Prentice +6 more
wiley +1 more source
Hippocampal Gene Expression Is Highly Responsive to Estradiol Replacement in Middle-Aged Female Rats. [PDF]
, 2015 In the hippocampus, estrogens are powerful modulators of neurotransmission, synaptic plasticity and neurogenesis. In women, menopause is associated with increased risk of memory disturbances, which can be attenuated by timely estrogen therapy.
Annie Rodolosse +7 more
core +1 more source
Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden [PDF]
, 2022 Gøril Rolfseng Grøntvedt +10 more
openalex +1 more source
Enhancer Rewiring Orchestrates Inflammation and Loss of Cell Identity During Muscle Stem Cell Aging
Aging Cell, Volume 25, Issue 1, January 2026.A comprehensive multi‐omic profiling of murine muscle stem cells across three ages and both sexes reveals extensive enhancer and 3D genome rewiring, concomitant with increased inflammation, lineage drift, loss of quiescence, and reduced myogenic potential.
Changyou Shi +17 more
wiley +1 more source
TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice [PDF]
, 2017 Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive ...
Birnbaumer, Lutz +10 more
core +1 more source
Klotho and Abdominal Aortic Calcifification: Results from NHANES 2013-2014 [PDF]
, 2022 Teng-Chi Ma, Feng Gao, Jing Zhou
openalex +1 more source
Genomic Perspective on Heterogeneity of Organs and Body Aging
Aging Cell, Volume 25, Issue 1, January 2026.Organ‐specific and whole‐body intrinsic aging metrics reveal heterogeneous organ aging, which potentially can arise from the interplay between static germline variation, somatic mutations, epigenetic drift, transposable elements, and mitochondrial DNA changes, highlighting genomic pathways for precision, organ‐targeted aging interventions.
Shabnam Salimi +2 more
wiley +1 more source