Results 1 to 10 of about 11,156 (184)
Hepatology, EarlyView., 2022 IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu +20 more
wiley +1 more source
Klotho protein in neurodegenerative disorders [PDF]
Neurological Sciences, 2018 The Klotho protein is a recently discovered protein and its overexpression is associated with life extension. Klotho deficiency or silencing of the Klotho gene in mice leads to an accelerated aging and short life, whereas overexpression of Klotho in mice extends lifespan.
Magdalena Torbus-Paluszczak +2 more
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Effects of klotho protein or klotho knockdown in porcine oocytes at different stages
Zygote, 2023 SummaryKlotho is a protein that plays different functions in female fertility. We have previously reported that klotho protein supplementation during in vitro maturation improves porcine embryo development, while klotho knockout for somatic cell cloning completely blocks full-term pregnancy in vivo.
Eun Pyo Kim +5 more
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NRF2 signalling in cytoprotection and metabolism
British Journal of Pharmacology, EarlyView., 2023 The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami +4 more
wiley +1 more source
Klotho Protein Promotes Adipocyte Differentiation [PDF]
Endocrinology, 2006 Mice with homozygous disruption of the klotho exhibit multiple age-related disorders and have barely detectable amounts of white adipose tissue. Although klotho expression in cultured adipocytes has been reported, little is known about its function in adipocytes.
Junsuke Ohta +7 more
openaire +3 more sources
Skeletal muscle as a regulator of the longevity protein, Klotho [PDF]
Frontiers in Physiology, 2014 Klotho is a powerful longevity protein that has been linked to the prevention of muscle atrophy, osteopenia, and cardiovascular disease. Similar anti-aging effects have also been ascribed to exercise and physical activity. While an association between muscle function and Klotho expression has been previously suggested from longitudinal cohort studies ...
Keith G Avin +11 more
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Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations
Frontiers in Aging, 2022 The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened lifespan, stunted growth, renal disease, hyperphosphatemia, hypercalcemia, vascular calcification, cardiac hypertrophy, hypertension, pulmonary disease, cognitive impairment ...
Gérald J. Prud’homme +4 more
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The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance [PDF]
Frontiers in Medicine, 2020 α-klotho (KL) is an anti-aging protein and has been shown to exert anti-inflammatory and anti-oxidative effects in the lung and pulmonary diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis. The current study investigated the direct effect of KL on the bronchial epithelium in regards to mucociliary clearance parameters ...
Jaleesa Garth +22 more
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Biological Role of Anti-aging Protein Klotho [PDF]
Journal of Lifestyle Medicine, 2015 Klotho-deficient mice have accelerated aging phenotypes, whereas overexpression of Klotho in mice extends lifespan. Klotho is an anti-aging single-pass membrane protein predominantly produced in the kidney, with shedding of the amino-terminal extracellular domain into the systemic circulation. Circulating levels of soluble Klotho decrease with age, and
Kyu Sang Park +4 more
openaire +3 more sources
Involvement of the Klotho Protein in Dentin Formation and Mineralization [PDF]
The Anatomical Record, 2007 AbstractKlotho‐deficient mice exhibit multiple pathological conditions resembling human aging. Our previous study showed alterations in the distribution of osteocytes and in the bone matrix synthesis in klotho‐deficient mice. Although the bone and tooth share morphological features such as mineralization processes and components of the extracellular ...
Masaki Noda +5 more
openaire +3 more sources