Results 11 to 20 of about 12,957 (269)

Role of Klotho Protein in Neuropsychiatric Disorders: A Narrative Review

Indian Journal of Clinical Biochemistry, 2022
Neuropsychiatric disorders are comprised of diseases having both the neurological and psychiatric manifestations. The increasing burden of the disease on the population worldwide makes it necessary to adopt measures to decrease the prevalence. The Klotho is a single pass transmembrane protein that decreases with age, has been associated with various ...
Amandeep Birdi, Sojit Tomo, Dharamveer Yadav, Praveen Sharma, Naresh Nebhinani, Prasenjit Mitra, Mithu Banerjee, Purvi Purohit   +7 more
openalex   +4 more sources

Klotho protein in neurodegenerative disorders [PDF]

Neurological Sciences, 2018
The Klotho protein is a recently discovered protein and its overexpression is associated with life extension. Klotho deficiency or silencing of the Klotho gene in mice leads to an accelerated aging and short life, whereas overexpression of Klotho in mice extends lifespan.
Magdalena Torbus-Paluszczak, Wojciech Bartman, Monika Adamczyk-Sowa   +2 more
openaire   +2 more sources

Klotho Protein Promotes Adipocyte Differentiation [PDF]

Endocrinology, 2006
Mice with homozygous disruption of the klotho exhibit multiple age-related disorders and have barely detectable amounts of white adipose tissue. Although klotho expression in cultured adipocytes has been reported, little is known about its function in adipocytes.
Yukana, Chihara, Hiromi, Rakugi, Kazuhiko, Ishikawa, Masashi, Ikushima, Yoshihiro, Maekawa, Junsuke, Ohta, Iwao, Kida, Toshio, Ogihara   +7 more
openaire   +2 more sources

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Effects of klotho protein or klotho knockdown in porcine oocytes at different stages

Zygote, 2023
SummaryKlotho is a protein that plays different functions in female fertility. We have previously reported that klotho protein supplementation during in vitro maturation improves porcine embryo development, while klotho knockout for somatic cell cloning completely blocks full-term pregnancy in vivo.
Eun Pyo Kim, Do Yon Kim, Changhoon Park, Seung-Min Yoo, Myung-Shin Lee, Geon A Kim   +5 more
openaire   +2 more sources

Can Soluble Klotho Protein Be a Potential Tumor Biomarker? [PDF]

American Journal of Clinical Pathology, 2013
To the Editor We read with great interest the article by Devaraj et al.1 According to the authors, soluble Klotho protein (sKL) appears to be an effective biological factor related to diabetes and chronic kidney disease. However, there is a paucity of data on sKL levels in patients with cancer.
Xiaowei Tang, Zhining Fan, Shu Huang
openalex   +3 more sources

Klotho inhibits the activation of NLRP3 inflammasome to alleviate lipopolysaccharide-induced inflammatory injury in A549 cells and restore mitochondrial function through SIRT1/Nrf2 signaling pathway

Chinese Journal of Physiology, 2023
Acute lung injury is a severe clinical condition constituting a major cause of mortality in intensive care units. This study aimed to investigate the role of klotho in alleviating lipopolysaccharide (LPS)-induced acute lung injury. LPS-induced acute lung
Yanjun Zeng, Gang Xu, Congrui Feng, Danyan Cai, Sizhi Wu, Yuanling Liu, Yuluo Chen, Wei Ma   +7 more
doaj   +1 more source

Research Models for Studying Vascular Calcification [PDF]

, 2020
Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process.
Babic, Milen, Giet, Markus van der, Herrmann, Jaqueline, Schuchardt, Mirjam, Tölle, Markus   +4 more
core   +1 more source

Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho.

PLoS ONE, 2020
Klotho is an age-extending, cognition-enhancing protein found to be down-regulated in aged mammals when age-related diseases start to appear. Low levels of Klotho occur in neurodegenerative diseases, kidney disease and many cancers.
Ci-Di Chen, Yuexuan Li, Arthur K Chen, Melissa A Rudy, Jason S Nasse, Ella Zeldich, Taryn J Polanco, Carmela R Abraham   +7 more
doaj   +1 more source

The Anti-Aging Hormone Klotho Promotes Retinal Pigment Epithelium Cell Viability and Metabolism by Activating the AMPK/PGC-1α Pathway

Antioxidants, 2023
Initially discovered by Makuto Kuro-o in 1997, Klotho is a putative aging-suppressor gene when overexpressed and accelerates aging when deleted in mice. Previously, we showed that α-Klotho regulates retinal pigment epithelium (RPE) functions and protects
Shuyan Zhou, Jacob Hum, Kaan Taskintuna, Stephanie Olaya, Jeremy Steinman, Junfeng Ma, Nady Golestaneh   +6 more
doaj   +1 more source