Frontiers in Cellular Neuroscience, 2019 The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as a full-length membrane-bound and as a soluble form after cleavage of the extracellular ...
Dongxue Li +5 more
doaj +1 more source
BMC Endocrine Disorders, 2023 Background Osteoporosis (OP) is one of the diseases that endanger the health of the elderly population. Klotho protein is a hormone with anti-aging effects. A few studies have discussed the relationship between Klotho and OP.
Jialin Jiang +9 more
doaj +1 more source
Klotho and SIRT1 changes from pre-diabetes to diabetes and pre-hypertension to hypertension
Diabetology & Metabolic Syndrome, 2021 Background Hypertension and diabetes are among the most important risk factors of cardiovascular diseases. Klotho and SIRT1 are known as anti-aging factors with beneficial effects on cardiovascular system.
Mahboobeh Yeganeh-Hajahmadi +3 more
doaj +1 more source
KLOTHO-VS heterozygosity, α-klotho protein levels and cognitive performance in Alzheimer's disease. [PDF]
Alzheimers Res TherAbstract Background KLOTHO -VS ( KL -VS) heterozygosity, a variant of the KLOTHO gene, and its encoded protein, α-Klotho, are associated with brain health and ...
Katonova A +9 more
europepmc +3 more sources
The effects of graded levels of calorie restriction : II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice [PDF]
, 2015 This work was supported by BBSRC BB009953/1 awarded to JRS and SEM. PK and CD were funded by the Erasmus exchange programme. JRS, SEM, DD, CG, LC, JJDH, YW, DELP, DL and AD are members of the BBSRC China Partnership Award, BB/J020028/1.Peer ...
Chen, Luonan +12 more
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KLOTHO PROTEIN AND ATHEROSCLEROSIS
Атеросклероз, 2017 The review provides an analysis of the literature data on the Klotho protein. The discovery and in-depth study of the Klotho gene and its protein broadened the notion of natural aging. The levels of Klotho protein in serum decrease with age and with certain diseases associated with aging, in particular, such as osteoporosis, arterial hypertension ...
O. V. Timoshchenko, Yu. P. Nikitin
openaire +2 more sources
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study [PDF]
, 2007 BACKGROUND: Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span. METHODS:We conducted a genome wide association study (Affymetrix 100K SNP GeneChip) for longevity-related traits in a ...
Benjamin, Emelia J +11 more
core +6 more sources
A Decreased Level of Serum Soluble Klotho Is an Independent Biomarker Associated with Arterial Stiffness in Patients with Chronic Kidney Disease [PDF]
, 2013 Background: Klotho was originally identified in a mutant mouse strain unable to express the gene that consequently showed shortened life spans. In humans, low serum Klotho levels are related to the prevalence of cardiovascular diseases in community ...
Inoue, Tatsuyuki +13 more
core +7 more sources
EBioMedicine, 2019 Background: The klotho (KL) gene is an anti-aging gene that has recently been shown to also function as a general tumor suppressor. However, there is currently only limited information regarding the potential molecular signals for regulation of Klotho ...
Bo Chen +10 more
doaj +1 more source
Analysis of Thisbe and Pyramus functional domains reveals evidence for cleavage of Drosophila FGFs [PDF]
, 2010 Background: As important regulators of developmental and adult processes in metazoans, Fibroblast Growth Factor (FGF) proteins are potent signaling molecules whose activities must be tightly regulated.
Stathopoulos, Angelike, Tulin, Sarah
core +4 more sources