Results 31 to 40 of about 11,156 (184)

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

NADPH oxidases: key modulators in aging and age-related cardiovascular diseases? [PDF]

, 2016
Reactive oxygen species (ROS) and oxidative stress have long been linked to aging and diseases prominent in the elderly such as hypertension, atherosclerosis, diabetes and atrial fibrillation (AF).
Abid, Abida, Adam, Adam, Ago, Agrawal, Al Ghouleh, Al Ghouleh, Allison, Altenhofer, Altenhofer, Anter, Ardanaz, Arking, Arking, Arunachalam, Azumi, Azumi, Bailey-Downs, Baniulis, Barman, Barry-Lane, Basset, Bedard, Bedard, Berniakovich, Bode, Bragado, Brooks, Brooks, Burstein, Buzek, Cai, Cai, Cai, Chang, Cifuentes, Cifuentes-Pagano, Cifuentes-Pagano, Colavitti, Cross, Csanyi, Csanyi, Csanyi, Csiszar, Daniel N. Meijles, de Haan, de Oliveira, Delafontaine, Delafontaine, Demidenko, Dikalova, Dornan, Douglas, Drummond, Drummond, Du, Dudley, Ebrahimian, Elahi, Elchuri, Fan, Finkel, Franklin, Frazziano, Frazziano, Fridman, Frost, Fukino, Gaggini, Gianni, Giordano, Giorgio, Go, Gray, Green, Greer, Griendling, Griendling, Griendling, Guzik, Guzik, Guzik, Hainaut, Hamilton, Harman, Haupt, Haurani, Haurani, He, Heidenreich, Helmcke, Hensley, Herranz, Higashi, Higashi, Hoeper, Hoeper, Hotta, Houben, Hsu, Hu, Hua, Irani, Italiano, Ito, Jin, Johnson, Judkins, Jun, Juraschek, Kaeberlein, Kajstura, Kalus, Kalyanaraman, Kapahi, Kaplan, Kavurma, Kenyon, Khan, Kim, Kim, Kim, Kleikers, Kodama, Kofler, Kokkinaki, Korantzopoulos, Kunieda, Kuro-o, Kuro-o, Kuro-o, Kurosu, Lakatta, Lakatta, Lakowski, Laleu, Lambeth, Landmesser, Lassegue, Lassegue, Le, Lee, Leng, Leonova, Li, Li, Li, Li, Li, Li, Li, Lim, Lin, Ling, Lithgow, Liu, Liu, Liu, Lopez-Otin, Lyle, Maier, Martinet, Matheu, Matsuno, McCance, Meijles, Melov, Migliaccio, Mihm, Mittal, Montezano, Morgan, Mouraret, Munoz-Espin, Murphy, Muzaffar, Nagai, Napoli, Nemoto, Neuman, Nisbet, Nishida, Nisimoto, Nonn, Olivetti, Olovnikov, Orr, Orsini, Oskarsson, O’Rourke, Pagano, Patrick J. Pagano, Pawlikowska, Pelicci, Perez, Persons, Pick, Pinton, Pozzoli, Ragnauth, Rainwater, Rajagopalan, Ranayhossaini, Ravikumar, Reilly, Ren, Rey, Rogina, Rosen, Ross, Saito, Saito, Saito, Sanghamitra Sahoo, Santiago, Satoh, Schnabel, Sentman, Sesso, Sheehan, Shin, Smith, Sorescu, Stenmark, Streeter, Suh, Sukhanov, Sundaresan, Taub, Tavana, ten Freyhaus, Tomilov, Touyz, Touyz, Touyz, Trinei, Tullet, Turgeon, Tyner, van Deursen, Van Remmen, Vendrov, Vendrov, Vigneron, Virmani, Viña, von Lohneysen, von Zglinicki, Vousden, Wang, Wang, Wang, Wang, Wang, Wang, Warboys, Wind, Wolf, Wolf, Wong, Wu, Xie, Xu, Yamamoto, Yeh, Youn, Zalba, Zalba, Zeldich, Zhang, Zhang, Zhang, Zuckerman   +273 more
core   +1 more source

PGC‐1α Activation by Polyphenols: A Pathway to Thermogenesis

Molecular Nutrition &Food Research, EarlyView.
Polyphenols, derived from dietary sources such as berries, undergo digestion and interact with gut microbiota, leading to their metabolization in the liver. This process influences bile acid composition, which in turn activates PGC1α, a key regulator of mitochondrial biogenesis and thermogenesis.
Nicholas Vannuchi, Luciana Pisani
wiley   +1 more source

Klotho as a Novel Cardioprotective Protein in Aged Heart

Elderly Health Journal, 2018
Editorial
Fatemeh Safari, Ali Dehghani
openaire   +3 more sources

The Longevity Protein Klotho: A Promising Tool to Monitor Lifestyle Improvements

Metabolites, 2023
Aging is not a disease; it is a natural evolution of human physiology. Medical advances have extended our life expectancy, but chronic diseases and geriatric syndrome continue to affect the increasingly aging population. Yet modern medicine perpetuates an approach based on treatment rather than prevention and education. In order to help solve this ever-
Jean-Sébastien Paquette, Caroline Rhéaume, Pierre Cordeau, Julie-Alexandra Moulin, Etienne Audet-Walsh, Virginie Blanchette, Jean-Philippe Drouin-Chartier, Alfred-Kodjo Toi, Angelo Tremblay   +8 more
openaire   +4 more sources

Identifying PDAP1 as a Biological Target on Human Longevity: Integration of Mendelian Randomization, Cohort, and Cell Experiments Validation Study

Aging Cell, EarlyView.
Integration of multi‐omics analyses reveals PDAP1 as one of the key regulators of longevity and aging. Mendelian randomization, colocalization, prospective studies, and in vitro experiments highlight PDAP1's effects on mortality, lifespan, and cellular senescence.
Tianzhichao Hou, Zimo Sha, Qi Wang, Yuanyue Zhu, Zheng Zhu, Huajie Dai, Yijie Zhu, Tiange Wang, Mian Li, Zhiyun Zhao, Yu Xu, Jieli Lu, Jie Zheng, Jing Ye, Weiqing Wang, Guang Ning, Yufang Bi, Weiguo Hu, Min Xu   +18 more
wiley   +1 more source

Secreted Klotho protein in sera and CSF: implication for post‐translational cleavage in release of Klotho protein from cell membrane

FEBS Letters, 2004
Klotho mutant mice exhibit a set of phenotypes resembling human ageing. Although the function of Klotho remains unclear, mediation of its pleiotropic functions by putative humoral factor(s) has been presumed. Newly established antibodies against Klotho allowed the detection of secreted Klotho, a candidate for the putative humoral factor, in sera and ...
Osamu Tohyama, Toshihiko Fujimori, Yoshihito Tsuji, Akiko Iwano, Nobuo Hashimoto, Kazuhiko Nozaki, Akihiro Imura, Yo-ichi Nabeshima   +7 more
openaire   +3 more sources

Can Soluble Klotho Protein Be a Potential Tumor Biomarker? [PDF]

American Journal of Clinical Pathology, 2013
To the Editor We read with great interest the article by Devaraj et al.1 According to the authors, soluble Klotho protein (sKL) appears to be an effective biological factor related to diabetes and chronic kidney disease. However, there is a paucity of data on sKL levels in patients with cancer.
Shu Huang, Xiao-Wei Tang, Zhi-Ning Fan
openaire   +3 more sources

Klotho is a substrate for α-, β- and γ-secretase [PDF]

, 2009
Klotho is an anti-aging protein with different functions of the full-length membrane protein and the secreted hormone-like form. Using overexpression and knock-down approaches as well as embryonic fibroblasts of knock-out mice we present evidence that ...
Bloch, Laura, Kaether, Christoph, Kuro-o, Makoto, Reichenbach, Daniela, Reiss, Karina, Saftig, Paul, Sineshchekova, Olga   +6 more
core   +1 more source

Klotho Protein Deficiency Leads to Overactivation of μ-Calpain [PDF]

Journal of Biological Chemistry, 2002
The klotho mouse is an animal model that prematurely shows phenotypes resembling human aging. Here we report that in homozygotes for the klotho mutation (kl(-/-)), alpha(II)-spectrin is highly cleaved, even before the occurrence of aging symptoms such as calcification and arteriosclerosis.
Toshihiko Fujimori, Mitsushi Inomata, Yuji Sato, Hiroshi Manya, Koji Takio, Tamao Endo, Naoshi Dohmae, Yo-ichi Nabeshima   +7 more
openaire   +3 more sources