Results 51 to 60 of about 11,156 (184)
Journal of Internal Medicine, EarlyView.Abstract Background and Objectives This population‐based study explores associations of fibroblast growth factor 21 (FGF21), a key modulator of processes linked to protein metabolism, with protein intake and muscle mass, and their relationships with all‐cause mortality.
Adrian Post +5 more
wiley +1 more source
Nutrition Bulletin, EarlyView.ABSTRACTHealthy midlife cognitive function (CF) reduces the risk of later cognitive decline. Emerging evidence suggests that chrono‐nutrition may be associated with CF. This cross‐sectional cohort study aimed to examine associations between chrono‐nutrition behaviours and CF in adults aged 45–65 years living in Cyprus.
Christiana A. Demetriou +12 more
wiley +1 more source
The angiotensin-(1-7)/Mas receptor a xis protects from endothelial cell senescence via klotho and Nrf2 activation [PDF]
, 2019 Endothelial cell senescence is a hallmark of va scular aging that pre disposes to vascular disease. We aimed to explore the capacity of the renin-angiotensin system (RAS) heptapeptide angiotensin (Ang)-(1-7) to counteract human ...
Bartha, José Luis +14 more
core +4 more sources
Experimental Physiology, EarlyView.Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu +4 more
wiley +1 more source
Assessment of the circulating klotho protein in lung cancer patients
Pathology & Oncology Research, 2018 The anti-aging factor, klotho has been identified as a tumor suppressor in various human cancers, including lung cancer. In vitro studies provided evidence that klotho expression influences the characteristics of lung cancer cells, however, in vivo results are lacking.
Judit Pako +8 more
openaire +5 more sources
The Putative Role of the Antiageing Protein Klotho in Cardiovascular and Renal Disease [PDF]
International Journal of Hypertension, 2012 Ageing is a multifactorial process often characterized by a progressive decline in physiological function(s). Ageing can and is often associated with an increased incidence of cardiovascular and renal disease. Klotho is a novel antiageing gene that encodes a protein with multiple pleiotropic functions including an emerging role in cardiorenal disease ...
Giuseppe Maltese, Janaka Karalliedde
openaire +7 more sources
Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults [PDF]
, 2016 The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic ...
Almeida, Bruno Ratier S. +10 more
core +4 more sources
Experimental Physiology, EarlyView.Abstract The mood stabilizers lithium and valproate are psychotropic medications widely used in clinical practice. Despite their proven benefits, many individuals stop their treatment due to the adverse effects. Chronic diarrhoea is a common reason for discontinuation of these drugs; however, the underlying mechanisms are unknown.
Sofia Cussotto +10 more
wiley +1 more source
Longevity Genes: From Primitive Organisms to Humans [PDF]
, 2002 A variety of lines of evidence indicate that aging and longevity are subject to genetic regulation, but until fairly recently the identity of these genes was unknown. This has changed dramatically over the last ten years.
Huber Warner
core
Epigenetics in the Eye: An Overview of the Most Relevant Ocular Diseases [PDF]
, 2017 Sight for mammals is one of the most appreciated senses. In humans there are several factors that contribute to the increment in all kind of eye diseases.
Alkozi, Hanan Awad +2 more
core +2 more sources