Results 51 to 60 of about 12,957 (269)

A protective role for FGF-23 in local defence against disrupted arterial wall integrity? [PDF]

, 2013
Increasing interest is focusing on the role of the FGF-23/Klotho axis in mediating vascular calcification. However, the underpinning mechanisms have yet to be fully elucidated. Murine VSMCs were cultured in calcifying medium for a 21d period. FGF-23 mRNA
Ben-Dov, Colin Farquharson, Demer, Ding, Dongxing Zhu, El-Abbadi, Eswarakumar, Franceschi, Hu, Isakova, Johnson, Jose Luis Millan, Khatiwala, Kok, Kurosu, Lim, Liu, Liu, Lorenz-Depiereux, Mackenzie, Mackenzie, Mackenzie, Mackenzie, MacRae, MacRae, MacRae, MacRae, MacRae, Medici, Murshed, Nasrallah, Neil C.W. Mackenzie, Rakugi, Razzaque, Roy, Rutsch, Rutsch, Saito, Salasznyk, Sali, Shalhoub, Shimada, Shimada, Shroff, Simmons, Sitara, Sitara, Speer, Speer, Srivaths, Urakawa, Vicky E. MacRae, Voigt, Wolf, Yamamoto, Yilmaz, Zhu, Zhu   +57 more
core   +1 more source

Hippocampal Gene Expression Is Highly Responsive to Estradiol Replacement in Middle-Aged Female Rats. [PDF]

, 2015
In the hippocampus, estrogens are powerful modulators of neurotransmission, synaptic plasticity and neurogenesis. In women, menopause is associated with increased risk of memory disturbances, which can be attenuated by timely estrogen therapy.
Annie Rodolosse, Csaba Vastagh, Erik Hrabovszky, Herbert Auer, Imre Kalló, Miklós Sárvári, Norbert Solymosi, Zsolt Liposits   +7 more
core   +1 more source

Current epigenetic aspects the clinical kidney researcher should embrace [PDF]

, 2017
Chronic kidney disease (CKD), affecting 10-12% of the world's adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature vascular disease and death.
Ekström, Tomas J., Nordfors, Louise, Shiels, Paul G., Stenvinkel, Peter, Van Craenenbroeck, Amaryllis H., Witasp, Anna   +5 more
core   +1 more source

The Long-Term Study of Urinary Biomarkers of Renal Injury in Spontaneously Hypertensive Rats

Kidney & Blood Pressure Research, 2021
Background: The age-related increase in blood pressure in spontaneously hypertensive rats (SHRs) is associated to cardiac hypertrophy, heart failure, and renal injury.
Sebastián Montoro-Molina, Andrés Quesada, Francisco O’Valle, Natividad Martín Morales, María del Carmen de Gracia, Isabel Rodríguez-Gómez, Antonio Osuna, Rosemary Wangensteen, Félix Vargas   +8 more
doaj   +1 more source

p-Cresyl sulfate [PDF]

, 2017
If chronic kidney disease (CKD) is associated with an impairment of kidney function, several uremic solutes are retained. Some of these exert toxic effects, which are called uremic toxins.
Glorieux, Griet, Gryp, Tessa, Vaneechoutte, Mario, Vanholder, Raymond   +3 more
core   +3 more sources

Mechanistic Roles of Matrilin-2 and Klotho in Modulating the Inflammatory Activity of Human Aortic Valve Cells

Cells, 2020
Background: Calcific aortic valve disease (CAVD) is a chronic inflammatory disease. Soluble extracellular matrix (ECM) proteins can act as damage-associated molecular patterns and may induce valvular inflammation.
Erlinda The, Qingzhou Yao, Peijian Zhang, Yufeng Zhai, Lihua Ao, David A. Fullerton, Xianzhong Meng   +6 more
doaj   +1 more source

Anti-Aging β-Klotho Gene-Activated Scaffold Promotes Rejuvenative Wound Healing Response in Human Adipose-Derived Stem Cells

Pharmaceuticals, 2021
Wound healing requires a tight orchestration of complex cellular events. Disruption in the cell-signaling events can severely impair healing. The application of biomaterial scaffolds has shown healing potential; however, the potential is insufficient for
Ashang L. Laiva, Fergal J. O’Brien, Michael B. Keogh   +2 more
doaj   +1 more source

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom [PDF]

, 2018
Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these ...
Arnold, Walter, Johnson, Richard J., Kuro-o, Makoto, Lanaspa, Miguel, Painer, Johanna, Ruf, Thomas, Shiels, Paul G., Stenvinkel, Peter   +7 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations

Frontiers in Aging, 2022
The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened lifespan, stunted growth, renal disease, hyperphosphatemia, hypercalcemia, vascular calcification, cardiac hypertrophy, hypertension, pulmonary disease, cognitive impairment ...
Gérald J. Prud’homme, Gérald J. Prud’homme, Mervé Kurt, Qinghua Wang, Qinghua Wang   +4 more
openaire   +3 more sources