Results 61 to 70 of about 11,156 (184)

Oxyntomodulin physiology and its therapeutic development in obesity and associated complications

The Journal of Physiology, EarlyView.
Abstract figure legend Physiological influences of OXM and its emerging insights from evidence on bariatric surgery effects. CCK, cholecystokinin; FGF21, fibroblast growth factor 21; GLUT4, glucose transporter type 4; IRS1, insulin receptor substrate‐1; NNMT, nicotinamide N‐methyltransferase; OXM, oxyntomodulin Abstract Incretins, such as glucagon‐like
Martin T. W. Kueh, Ming Chuen Chong, Alexander D. Miras, Carel W. le Roux   +3 more
wiley   +1 more source

The Antiaging Protein Klotho Enhances Oligodendrocyte Maturation and Myelination of the CNS [PDF]

The Journal of Neuroscience, 2013
We have previously shown that myelin abnormalities characterize the normal aging process of the brain and that an age-associated reduction in Klotho is conserved across species. Predominantly generated in brain and kidney, Klotho overexpression extends life span, whereas loss of Klotho accelerates the development of aging-like phenotypes.
Chen, Ci-Di, Sloane, Jacob A., Li, Hu, Aytan, Nurgul, Giannaris, Eustathia Lela, Zeldich, Ella, Hinman, Jason D., Dedeoglu, Alpaslan, Rosene, Douglas L., Bansal, Rashmi, Leubke, Jennifer I., Kuro-o, Makoto, Abraham, Carmela R.   +12 more
openaire   +3 more sources

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice [PDF]

, 2017
Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive ...
Birnbaumer, Lutz, Harada, Eri, Ishikawa, Tatsuya, Kitajima, Naoyuki, Kumagai, Yoshito, Nishida, Motohiro, Nishimura, Akiyuki, Numaga Tomita, Takuro, Oda, Sayaka, Shimauchi, Tsukasa, Tomizaki, Takashi   +10 more
core   +1 more source

Exosomes, autophagy, and cancer: A complex triad

International Journal of Cancer, Volume 157, Issue 3, Page 405-415, 1 August 2025.
Abstract Cancer remains one of the leading causes of death worldwide. Despite remarkable progress in prevention, diagnosis, and therapy, the incidence of certain types of cancer persists, urging the identification of clinically relevant biomarkers and the development of novel therapeutic strategies to improve clinical outcomes and overcome treatment ...
María Guerra‐Andrés, Álvaro F. Fernández, Tania Fontanil   +2 more
wiley   +1 more source

The Biological Role of Klotho Protein in the Development of Cardiovascular Diseases

BioMed Research International, 2018
Klotho is a membrane-bound or soluble antiaging protein, whose protective activity is essential for a proper function of many organs. In 1997, an accidental insertion of a transgene led to creation of transgenic mice with several age-related disorders.
Agnieszka Olejnik, Aleksandra Franczak, Anna Krzywonos-Zawadzka, Marta Kałużna-Oleksy, Iwona Bil-Lula   +4 more
openaire   +3 more sources

Methionine restriction improves renal insulin signalling in aged kidneys. [PDF]

, 2016
Dietary methionine restriction (MR) leads to loss of adiposity, improved insulin sensitivity and lifespan extension. The possibility that dietary MR can protect the kidney from age-associated deterioration has not been addressed. Aged (10-month old) male
Ables, Agouni, Barzilai, Baylis, Baylis, Bitzer, Black, Cheng, Emma K. Lees, Friederich, Hasek, Hasek, Heather M. Wilson, Hu, Hu, Huffman, Kim, Kitada, Kitada, Laura A. Forney, Lees, Louise Grant, Martin, Mirela Delibegovic, Muzumdar, Nimesh Mody, Orentreich, Patil, Paul A.J. Brown, Pfaffl, Plaisance, Richie, Rodwell, Saltiel, Selman, Strable, Thomas, Thomas Gettys, von Manteuffel, Weinstein, Zhang, Zheng, Zhou   +42 more
core   +1 more source

Genetic diseases of renal phosphate handling [PDF]

, 2006
UNLABELLED: Renal control of systemic phosphate homeostasis is critical as evident from inborn and acquired diseases causing renal phosphate wasting. At least three transport proteins are responsible for renal phosphate reabsorption: NAPI-IIa (SLC34A1 ...
Wagner, Carsten A., Rubio-Aliaga, Isabel, Biber, Jürg, Hernando, Nati   +3 more
core   +3 more sources

The transcription factor RIP140 regulates interferon γ signaling in breast cancer

International Journal of Cancer, Volume 157, Issue 1, Page 170-182, 1 July 2025.
What's new? Interferon γ (IFNγ) is a key player in breast cancer, with the potential to induce apoptosis and to shift tumors into a dormant state. However, it also may promote carcinogenesis and angiogenesis. In this study, transcriptomic analysis identified the transcription factor RIP140 as a key regulator of IFNγ signaling in breast cancer.
Stéphan Jalaguier, Axel Kuehn, Chloé Petitpas, Arnaud Dulom, Rémy Jacquemont, Cindy Assi, Sophie Sixou, Udo Jeschke, Jacques Colinge, Vincent Cavaillès   +9 more
wiley   +1 more source

Calcinosis cutis of the lower legs – hyperphosphatemic familial tumoral calcinosis in a patient with GALNT3 mutation

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
David Ranzinger, Tobias Schaefer, Franziska Schauer, Kilian Eyerich, Anna Caroline Pilz   +4 more
wiley   +1 more source

Fibroblast Growth Factor 23 and Sarcopenia in Maintenance Haemodialysis Population

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Background Sarcopenia is defined as the loss of muscle mass, strength, and/or performance. It is strongly associated with all‐cause mortality. Fibroblast growth factor 23 (FGF23) is markedly elevated in patients with chronic kidney disease, especially those receiving maintenance dialysis.
Limy Wong, Rachel Kenny, Jenny Y. Y. Ooi, Yung Shing Tsang, Emily Schembri, Lawrence P. McMahon   +5 more
wiley   +1 more source