Results 71 to 80 of about 11,156 (184)
Obesity‐related glomerulopathy: How it happens and future perspectives
Diabetic Medicine, Volume 42, Issue 6, June 2025.Abstract Obesity‐related glomerulopathy (ORG) is an emerging complication of excess adiposity. Its incidence rises alongside the obesity pandemic. Up to 40% of individuals can be affected by ORG, irrespective of the status of glomerular filtration rate and albuminuria.
Jian‐Wen Samuel Lee‐Boey +7 more
wiley +1 more source
Evidence against a direct role of klotho in insulin resistance [PDF]
, 2018 The klotho gene may be involved in the aging process. Klotho is a coactivator of FGF23, a regulator of phosphate and vitamin D metabolism. It has also been reported to be downregulated in insulin resistance syndromes and paradoxically to directly inhibit
Lorenzi, Olivier +6 more
core +1 more source
, 2017 If chronic kidney disease (CKD) is associated with an impairment of kidney function, several uremic solutes are retained. Some of these exert toxic effects, which are called uremic toxins.
Glorieux, Griet +3 more
core +3 more sources
Advanced Science, Volume 12, Issue 18, May 15, 2025.USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang +16 more
wiley +1 more source
Chronic kidney disease and fibrosis : the role of uremic retention solutes [PDF]
, 2015 Chronic kidney disease (CKD) is a major global health concern, and the uremic state is highly associated with fibrogenesis in several organs and tissues.
Glorieux, Griet +4 more
core +3 more sources
Circulating Klotho levels: clinical relevance and relationship with tissue Klotho expression [PDF]
, 2013 Klotho is a protein that exerts paracrine and endocrine functions. In chronic kidney disease (CKD), its expression is decreased in several tissues. This decrease probably plays important roles in various complications associated with CKD, in both a ...
Drüeke, Tilman B., Massy, Ziad A.
core +1 more source
Regulation of phosphate transport in proximal tubules [PDF]
, 2018 Homeostasis of inorganic phosphate (Pi) is primarily an affair of the kidneys. Reabsorption of the bulk of filtered Pi occurs along the renal proximal tubule and is initiated by apically localized Na+-dependent Pi cotransporters.
Biber, J. +3 more
core
Systemic Control of Bone Homeostasis by FGF23 Signaling [PDF]
, 2016 The regulation of phosphate metabolism as an influence on bone homeostasis is profound. Recent advances in understanding the systemic control of Fibroblast growth factor-23 (FGF23) has uncovered novel effectors of endocrine feedback loops for calcium ...
Clinkenbeard, Erica L. +1 more
core +1 more source
Hippocampal Gene Expression Is Highly Responsive to Estradiol Replacement in Middle-Aged Female Rats. [PDF]
, 2015 In the hippocampus, estrogens are powerful modulators of neurotransmission, synaptic plasticity and neurogenesis. In women, menopause is associated with increased risk of memory disturbances, which can be attenuated by timely estrogen therapy.
Annie Rodolosse +7 more
core +1 more source
Anti-Inflammatory Role of the Klotho Protein and Relevance to Aging
CellsThe α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor 23 (FGF23). It is produced in the kidneys, brain and other sites. Klotho insufficiency causes hyperphosphatemia and other anomalies. Importantly, it is associated with chronic pathologies (often age-related) that have an inflammatory component.
Gérald J. Prud’homme, Qinghua Wang
openaire +3 more sources