Results 81 to 90 of about 12,957 (269)
MicroRNAs Regulate Vascular Medial Calcification [PDF]
, 2014 Vascular calcification is highly prevalent in patients with coronary artery disease and, when present, is associated with major adverse cardiovascular events, including an increased risk of cardiovascular mortality.
Leopold, Jane A.
core +2 more sources
Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden [PDF]
, 2022 Gøril Rolfseng Grøntvedt +10 more
openalex +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Validation of an Immunoassay for Soluble Klotho Protein [PDF]
American Journal of Clinical Pathology, 2012 Abstract The Klotho gene has been identified as an aging suppressor gene that encodes a transmembrane protein, which is expressed primarily in renal tubules. There are 2 forms of Klotho, membrane and secreted. However, there is a paucity of data on levels of soluble Klotho in diseases like diabetes and kidney disease.
Sridevi Devaraj +3 more
openaire +1 more source
New markers of cardio-renal links in chronic kidney disease
Терапевтический архив, 2013 AIM: To study the clinical significance of determining the serum concentration of phosphorus and calcium metabolism regulators - the morphogenetic proteins FGF-23 and Klotho in patients with different stages of chronic kidney disease (CKD)/MATERIAL AND ...
L Iu Milovanova +3 more
doaj
Journal of NanobiotechnologyAcute kidney injury (AKI) is a life-threating syndrome characterized by sudden loss of kidney function, and its management is challenging and often suboptimal.
Xiao-Hui Deng +11 more
doaj +1 more source
Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives
PROTEOMICS, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto +2 more
wiley +1 more source
FEBS Letters, 2004 Klotho mutant mice exhibit a set of phenotypes resembling human ageing. Although the function of Klotho remains unclear, mediation of its pleiotropic functions by putative humoral factor(s) has been presumed. Newly established antibodies against Klotho allowed the detection of secreted Klotho, a candidate for the putative humoral factor, in sera and ...
Imura, Akihiro +7 more
openaire +2 more sources
Journal of Diabetes Investigation, EarlyView.Dapagliflozin improved glycemic control and insulin resistance while preserving skeletal muscle mass, body weight, and renal function over 2 years in a patient with Werner syndrome. These findings suggest that SGLT2 inhibitors may be used safely with beneficial effects in patients with Werner syndrome.
Takashi Yagi +7 more
wiley +1 more source
Skeletal muscle as a regulator of the longevity protein, Klotho [PDF]
Frontiers in Physiology, 2014 Klotho is a powerful longevity protein that has been linked to the prevention of muscle atrophy, osteopenia, and cardiovascular disease. Similar anti-aging effects have also been ascribed to exercise and physical activity. While an association between muscle function and Klotho expression has been previously suggested from longitudinal cohort studies ...
Keith G Avin +11 more
openaire +3 more sources