Results 81 to 90 of about 11,156 (184)

KLOTHO methylation is linked to uremic toxins and chronic kidney disease [PDF]

, 2012
Epigenetic regulation plays a major role in uremic toxin-induced chronic kidney disease (CKD) progression. The KLOTHO protein is a key modulator of homeostasis in renal function.
Wu, Vin-Cent, Young, Guang-Huar
core   +1 more source

Developmental immunolocalization of the Klotho protein in mouse kidney epithelial cells

European Journal of Histochemistry, 2014
A defect in Klotho gene expression in the mouse results in a syndrome that resembles rapid human aging. In this study, we investigated the detailed distribution and the time of the first appearance of Klotho in developing and adult mouse kidney. Kidneys from 16-(F16), 18-(F18) and 20-day-old (F20) fetuses, 1- (P1), 4- (P4), 7- (P7), 14- (P14), and 21 ...
Ju-Young Jung, Y.J. Kim, Si-Yun Ryu, J. Kim, J.H. Song, M.Y. Lee, S.R. Park   +6 more
openaire   +4 more sources

Hypophosphatemic rickets: Revealing Novel Control Points for Phosphate Homeostasis [PDF]

, 2014
Rapid and somewhat surprising advances have recently been made towards understanding the molecular mechanisms causing heritable disorders of hypophosphatemia.
Econs, Michael J., Hum, Julia M., White, Kenneth E.   +2 more
core   +1 more source

Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model [PDF]

, 2011
AS (Apert syndrome) is a congenital disease composed of skeletal, visceral and neural abnormalities, caused by dominant-acting mutations in FGFR2 [FGF (fibroblast growth factor) receptor 2].
Anderson, Beenken, Bochukova, Burgar, Celli, Cohen, De Moerlooze, Duan, Duchesne, Ezzat, Fairbanks, Hajihosseini, Hajihosseini, Hajihosseini, Hajihosseini, Hajihosseini, Hanneken, Ibrahimi, Jang, Jang, Jang, John K. Heath, Jones, Kawano, Klein, Kuro-o, Lee M. Wheldon, Lewis, Maquat, McKeehan, Mendell, Meyers, Miki, Mohammad K. Hajihosseini, Muhlemann, Naila Khodabukus, Naski, Nelson, Oldridge, Peters, Polanska, Ricol, Saito, Sekine, Slaney, Smith, Susannah J. Patey, Takaishi, Tanimoto, Terada, Terence G. Smith, Tsang, Tsukuno, Werner, Wheldon, Wilkie, Yamaguchi, Zhang   +57 more
core   +3 more sources

New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease [PDF]

, 2016
In chronic kidney disease inflammatory processes and stimulation of immune cells result in overproduction of free radicals. In combination with a reduced antioxidant capacity this causes oxidative stress.
Osorio-Alonso, Horacio, Pedraza-Chaverri, José, Scholze, Alexandra, Sánchez-Lozada, Laura G, Tapia, Edilia   +4 more
core   +2 more sources

Soluble Klotho protein as a novel serum biomarker in patients with acromegaly

Archives of Medical Science, 2016
Acromegaly is a chronic disease caused by overproduction of growth hormone, in most cases due to excessive secretion from a pituitary adenoma [1, 2]. The incidence of acromegaly is approximately 5 cases per million per year, and the prevalence is estimated to be about 60 cases per million [3].
Jerzy S. Tarach, Anna Maria Dąbrowska
openaire   +3 more sources

On the relationship between proteinuria and plasma phosphate. [PDF]

, 2017
Albuminuria is strongly associated with renal and cardiovascular outcomes independently of renal function level. However, the pathophysiology of these associations is debated.
Courbebaisse, M., de Seigneux, S., Wilhelm-Bals, A.   +2 more
core   +1 more source

Molecular function of Klotho protein

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2003
openaire   +4 more sources

Inflammation-Induced Klotho Deficiency: A Possible Key Driver of Chronic Kidney Disease Progression. [PDF]

Int J Gen Med
Liang Y, Zhang Q, Qian JR, Li SS, Liu QF.   +4 more
europepmc   +1 more source

Klotho null mutation leads to retinal degeneration characterized by functional impairment, gliosis, and deposition of amyloid-beta and hyperphosphorylated tau proteins. [PDF]

PLoS One
Chen ZJ, Wu CY, Hsiao FY, Ma JC, Lai G, Chang HH, Lin DP.   +6 more
europepmc   +1 more source