Vaccines, 2021 Most approved vaccines against COVID-19 have to be administered in a prime/boost regimen. We engineered a novel vaccine based on a chimeric human adenovirus 5 (hAdV5) vector.
M. Verónica López +20 more
doaj +1 more source
Protein crystals in Adenovirus type 5-infected cells: requirements for intranuclear crystallogenesis, structural and functional analysis. [PDF]
PLoS ONE, 2008 Intranuclear crystalline inclusions have been observed in the nucleus of epithelial cells infected with Adenovirus serotype 5 (Ad5) at late steps of the virus life cycle.
Laure Franqueville +10 more
doaj +1 more source
‘Knobs-into-holes’ engineering of antibody CH3 domains for heavy chain heterodimerization [PDF]
"Protein Engineering, Design and Selection", 1996 'Knobs-into-holes' was originally proposed by Crick in 1952 as a model for the packing of amino acid side chains between adjacent alpha-helices. 'Knobs-into-holes' is demonstrated here as a novel and effective design strategy for engineering antibody heavy chain homodimers for heterodimerization.
J B, Ridgway, L G, Presta, P, Carter
openaire +2 more sources
De Museale Traditie binnen de KNOB [PDF]
, 1989 [No abstract ...
Theo M. Elsing, Elsing, Theo M.
core +1 more source
Structural effects of methionine oxidation on isolated subdomains of human fibrin D and αC regions. [PDF]
PLoS ONE, 2014 Oxidation of key methionine residues on fibrin leads to altered fibrin polymerization producing severely altered fibrin gel structure and function. This is important because fibrinogen and its modification by oxidative stress have been implicated as key ...
Patrick R Burney +2 more
doaj +1 more source
PLoS Pathogens, 2017 Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) and Knob-associated Histidine-rich Protein (KAHRP) are directly linked to malaria pathology. PfEMP1 and KAHRP cluster on protrusions (knobs) on the P.
Erin E Cutts +6 more
doaj +1 more source
Co-chaperone involvement in knob biogenesis implicates host-derived chaperones in malaria virulence.
PLoS Pathogens, 2021 The pathology associated with malaria infection is largely due to the ability of infected human RBCs to adhere to a number of receptors on endothelial cells within tissues and organs.
Mathias Diehl +12 more
doaj +1 more source
The Maturation of Murine Dendritic Cells Induced by Human Adenovirus Is Mediated by the Fiber Knob Domain [PDF]
Journal of Biological Chemistry, 2003 We investigated the mechanism of adenovirus serotype 5 (Ad5)-mediated maturation of bone marrow-derived murine dendritic cells (DC) using (i) Ad5 vectors with wild-type capsid (AdE1 degrees, AdGFP); (ii) Ad5 vector mutant deleted of the fiber C-terminal knob domain (AdGFPDeltaknob); and (iii) capsid components isolated from Ad5-infected cells or ...
Valérie, Molinier-Frenkel +7 more
openaire +2 more sources
De KNOB, Cuypers en kasteel De Haar. Inleiding op het themanummer [PDF]
, 1996 [No abstract ...
Ottenheym, Koen A., Koen A. Ottenheym
core +1 more source
Histidine-rich domain of the knob protein of the human malaria parasite Plasmodium falciparum. [PDF]
Proceedings of the National Academy of Sciences, 1986 Membranes of erythrocytes infected with the human malaria parasite Plasmodium falciparum develop protrusions called knobs. These structures are essential for the survival of the parasite in the host, and their induction requires the synthesis of the knob protein by the parasite. We describe the isolation of a cDNA clone encoding the amino-terminal half
A, Kilejian +3 more
openaire +2 more sources