Results 11 to 20 of about 1,849,891 (275)
Knob domain of Fiber 2 protein provides full protection against fowl adenovirus serotype 4. [PDF]
Virus Res, 2023 Highly pathogenic fowl adenovirus serotype 4 (FAdV-4) is an acute infectious disease with severe economic impact, causing chicken hepatitis hydropericardium syndrome (HHS) and high mortality. In the present study, we evaluated the immunogenicity of the recombinant Fiber2-knob protein (F2-Knob) as an FAdV-4 candidate subunit vaccine in 14-day-old SPF ...
Song Y +6 more
europepmc +4 more sources
An antibody with a variable-region coiled-coil "knob" domain. [PDF]
Angew Chem Int Ed Engl, 2014 AbstractThe X‐ray crystal structure of a bovine antibody (BLV1H12) revealed a unique structure in its ultralong heavy chain complementarity determining region 3 (CDR3H) that folds into a solvent‐exposed β‐strand “stalk” fused to a disulfide crosslinked “knob” domain.
Zhang Y +8 more
europepmc +5 more sources
Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain. [PDF]
J Control Release, 2011 Hepatocytes and acinar cells exhibit high-efficiency, fiber-dependent internalization of adenovirus; however, viral capsids have unpredictable immunological effects and are challenging to develop into targeted drug carriers. To exploit this internalization pathway and minimize the use of viral proteins, we developed a simple gene product that self ...
Sun G +4 more
europepmc +5 more sources
Incorporation of Peptides Targeting EGFR and FGFR1 into the Adenoviral Fiber Knob Domain and Their Evaluation as Targeted Cancer Therapies. [PDF]
Hum Gene Ther, 2015 Oncolytic virotherapies based on adenovirus 5 (Ad5) hold promise as adjunctive cancer therapies; however, their efficacy when delivered systemically is hampered by poor target cell specificity and preexisting anti-Ad5 immunity. Ovarian cancer represents a promising target for virotherapy, since the virus can be delivered locally ...
Uusi-Kerttula H +8 more
europepmc +4 more sources
, 2022 Voorwoord bij een nieuwe rubriek met afstudeerwerk Het Bulletin KNOB biedt een podium aan zowel ervaren onderzoekers als aanstormend talent. Met een zekere regelmaat publiceren afgestudeerden een artikel op basis van hun masterscriptie of ander onderzoek
Missoorten, Margot +18 more
core +1 more source
Viruses, 2023 Outbreaks of hydropericardium hepatitis syndrome caused by fowl adenovirus serotype 4 (FAdV-4) with a novel genotype have been reported in China since 2015, with significant economic losses to the poultry industry.
Xiao Chen +10 more
doaj +1 more source
PLoS ONE, 2023 Cancer cells bypass cell death by changing the expression of the BCL-2 family of proteins, which are apoptotic pathway regulators. Upregulation of pro-survival BCL-2 proteins or downregulation of cell death effectors BAX and BAK interferes with the ...
Jennifer Yi +6 more
doaj +2 more sources
Endothelial cells adhere to the rgd domain and the fibrinogen-like terminal knob of tenascin [PDF]
Journal of Cell Science, 1993 ABSTRACT We have found that endothelial cells adhere much more strongly than fibroblasts to domains of tenascin and fibronectin. Endothelial cells adhered weakly, without spreading, to bacterial expression proteins corresponding to the tenth fibronectin type III (FN-III) domain of fibronectin, which contains the RGD. A larger fibronectin
P, Joshi +3 more
openaire +3 more sources
Frontiers in Immunology, 2023 In this work we present a novel symmetric bispecific antibody format based on engraftments of cattle-derived knob paratopes onto peripheral loops of the IgG1 Fc region.
Desislava Yanakieva +11 more
doaj +1 more source
Materiële echtheid of geschiedvervalsing [PDF]
, 2020 In 1917 publiceerde de Koninklijke Oudheidkundige Bond (KNOB) ‘Grondbeginselen en voorschriften voor het behoud, de herstelling en de uitbreiding van oude bouwwerken’. Deze betekenden een breuk met de restauratieopvattingen van P.J.H.
Somer, Kees, Kees Somer
core +1 more source