Results 31 to 40 of about 8,444 (194)
Structural effects of methionine oxidation on isolated subdomains of human fibrin D and αC regions. [PDF]
PLoS ONE, 2014 Oxidation of key methionine residues on fibrin leads to altered fibrin polymerization producing severely altered fibrin gel structure and function. This is important because fibrinogen and its modification by oxidative stress have been implicated as key ...
Patrick R Burney +2 more
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PLoS Pathogens, 2017 Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) and Knob-associated Histidine-rich Protein (KAHRP) are directly linked to malaria pathology. PfEMP1 and KAHRP cluster on protrusions (knobs) on the P.
Erin E Cutts +6 more
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Co-chaperone involvement in knob biogenesis implicates host-derived chaperones in malaria virulence.
PLoS Pathogens, 2021 The pathology associated with malaria infection is largely due to the ability of infected human RBCs to adhere to a number of receptors on endothelial cells within tissues and organs.
Mathias Diehl +12 more
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Histidine-rich domain of the knob protein of the human malaria parasite Plasmodium falciparum. [PDF]
Proceedings of the National Academy of Sciences, 1986 Membranes of erythrocytes infected with the human malaria parasite Plasmodium falciparum develop protrusions called knobs. These structures are essential for the survival of the parasite in the host, and their induction requires the synthesis of the knob protein by the parasite. We describe the isolation of a cDNA clone encoding the amino-terminal half
A, Kilejian +3 more
openaire +2 more sources
Implementation of a Random Variable Universefuzzy Controller in Medical Helmet
Journal of Harbin University of Science and Technology, 2023 The current adaptive fuzzy control methods was difficult to achieve good results in practical problems. Aiming at this problem , a fuzzy controller with a random variation domain was proposed. Firstly , a simple and accurate random scaling factor
WANGYue, ZHAOHui, ZHANGYuan, WULunhua
doaj +1 more source
Viruses, 2020 The study of viruses causing acute respiratory distress syndromes (ARDS) is more essential than ever at a time when a virus can create a global pandemic in a matter of weeks.
Marc-André Hograindleur +7 more
doaj +1 more source
Subtelomeric Chromatin in the Fission Yeast S. pombe
Microorganisms, 2021 Telomeres play important roles in safeguarding the genome. The specialized repressive chromatin that assembles at telomeres and subtelomeric domains is key to this protective role.
Rajesh K. Yadav +4 more
doaj +1 more source
Derivation of a myeloid cell-binding adenovirus for gene therapy of inflammation. [PDF]
PLoS ONE, 2012 The gene therapy field is currently limited by the lack of vehicles that permit efficient gene delivery to specific cell or tissue subsets. Native viral vector tropisms offer a powerful platform for transgene delivery but remain nonspecific, requiring ...
Michael O Alberti +7 more
doaj +1 more source
The Interaction between the Fiber Knob Domain and the Cellular Attachment Receptor Determines the Intracellular Trafficking Route of Adenoviruses [PDF]
Journal of Virology, 2003 ABSTRACT Most of the presently used adenovirus (Ad) vectors are based on serotype 5. However, the application of these vectors is limited by the native tropism of Ad5. To address this problem, a series of fiber chimeric vectors were produced to take advantage of the different cellular receptors used by Ad of different subgroups. In this study
Dmitry M, Shayakhmetov +5 more
openaire +2 more sources
BMC Genetics, 2002 Background Polymorphisms in the gene that encodes the human cellular receptor for group B coxsackieviruses and adenoviruses (HCAR) could be responsible for differences in susceptibility to infections with these pathogens.
Inge Thoelen +3 more
doaj +2 more sources