Results 11 to 20 of about 1,953 (104)
Effect of allotypic variation of human IgG1 on the thermal stability of disulfide-linked knobs-into-holes mutants of the Fc for stable bispecific antibody design [PDF]
Antibody Therapeutics, 2019 Hiroki Akiba +2 more
exaly +2 more sources
Bispecific antibodies with Fab-arms featuring exchanged antigen-binding constant domains
Biochemistry and Biophysics Reports, 2021 Monoclonal antibodies can acquire the property of engagement of a second antigen via fusion methods or modification of their CDR loops, but also by modification of their constant domains, such as in the mAb2 format where a set of mutated amino acid ...
Filippo Benedetti +5 more
doaj +1 more source
Rapsyn's knobs and holes: eight tetratrico peptide repeats [PDF]
Biochemical Journal, 1996 Ponting CC, Phillips C.
exaly +2 more sources
STAR Protocols, 2021 Summary: Follistatin-like 3 (FSTL3) is an endogenous antagonist against transforming growth factor-β family ligands. Monovalent FSTL3-Fc fusion protein (mono-FSTL3-Fc) generated with knobs-into-holes technology overcomes limitations of current anti ...
Takayuki Ozawa +2 more
doaj +1 more source
Crystal structure of an anti-Ang2 CrossFab demonstrates complete structural and functional integrity of the variable domain. [PDF]
PLoS ONE, 2013 Bispecific antibodies are considered as a promising class of future biotherapeutic molecules. They comprise binding specificities for two different antigens, which may provide additive or synergistic modes of action.
Sebastian Fenn +12 more
doaj +1 more source
An integrated approach for characterizing immunogenic responses toward a bispecific antibody
mAbs, 2021 Bispecific antibodies (bsAbs) recognize and bind two different targets or two epitopes of the same antigen, making them an attractive diagnostic and treatment modality.
Sivan Cohen +14 more
doaj +1 more source
iScience, 2021 Summary: Targeting the signaling pathway of growth differentiation factor 8 (GDF8), also known as myostatin, has been regarded as a promising strategy to increase muscle mass in the elderly and in patients.
Takayuki Ozawa +7 more
doaj +1 more source
iScience, 2022 Summary: Ebola virus (EBOV) and Marburg virus (MARV) are highly pathogenic viruses in humans, against which approved antivirals are lacking. During EBOV and MARV infection, coiled-coil mediated oligomerization is essential for the virion protein 35 (VP35)
Luca Zinzula +6 more
doaj +1 more source
IMGT® Nomenclature of Engineered IGHG Variants Involved in Antibody Effector Properties and Formats
Antibodies, 2022 The constant region of the immunoglobulin (IG) or antibody heavy gamma chain is frequently engineered to modify the effector properties of the therapeutic monoclonal antibodies.
Marie-Paule Lefranc, Gérard Lefranc
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2019 Background Human epidermal growth factor receptor 2 (HER2) is overexpressed in multiple cancers, which is associated with poor prognosis. Herceptin and other agents targeting HER2 have potent antitumor efficacy in patients with HER2-positive cancers ...
Shengnan Yu +9 more
doaj +1 more source