Results 21 to 30 of about 2,562 (158)

Ebola and Marburg virus VP35 coiled-coil validated as antiviral target by tripartite split-GFP complementation

iScience, 2022
Summary: Ebola virus (EBOV) and Marburg virus (MARV) are highly pathogenic viruses in humans, against which approved antivirals are lacking. During EBOV and MARV infection, coiled-coil mediated oligomerization is essential for the virion protein 35 (VP35)
Luca Zinzula, Angela Maria Mereu, Massimiliano Orsini, Christine Seeleitner, Andreas Bracher, István Nagy, Wolfgang Baumeister   +6 more
doaj   +1 more source

Increased yields and biological potency of knob-into-hole-based soluble MHC class II molecules [PDF]

Nature Communications, 2019
AbstractAssembly of soluble peptide-major histocompatibility complex class II (pMHCII) monomers into multimeric structures enables the detection of antigen-specific CD4+ T cells in biological samples and, in some configurations, their reprogramming in vivo.
Pau Serra, Nahir Garabatos, Santiswarup Singha, César Fandos, Josep Garnica, Patricia Solé, Daniel Parras, Jun Yamanouchi, Jesús Blanco, Meritxell Tort, Mireia Ortega, Yang Yang, Kristofor K. Ellestad, Pere Santamaria   +13 more
openaire   +3 more sources

IMGT^® Nomenclature of Engineered IGHG Variants Involved in Antibody Effector Properties and Formats

Antibodies, 2022
The constant region of the immunoglobulin (IG) or antibody heavy gamma chain is frequently engineered to modify the effector properties of the therapeutic monoclonal antibodies.
Marie-Paule Lefranc, Gérard Lefranc
doaj   +1 more source

A Randomized, Sham‐Controlled Trial of Repetitive Transcranial Magnetic Stimulation Targeting M1 and S2 in Central Poststroke Pain: A Pilot Trial

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Central poststroke pain (CPSP), a neuropathic pain condition, is difficult to treat. Repetitive transcranial magnetic stimulation (rTMS) targeted to the primary motor cortex (M1) can alleviate the condition, but not all patients respond. We aimed to assess a promising alternative rTMS target, the secondary somatosensory cortex (S2),
Juhani Ojala, Jukka Vanhanen, Hanna Harno, Pantelis Lioumis, Selja Vaalto, Mari A. Kaunisto, Jukka Putaala, Marko Kangasniemi, Erika Kirveskari, Jyrki P. Mäkelä, Eija Kalso   +10 more
wiley   +1 more source

Vector design for enhancing expression level and assembly of knob-into-hole based FabscFv-Fc bispecific antibodies in CHO cells

Antibody Therapeutics, 2022
Abstract Background Two-armed FabscFv-Fc is a favoured bispecific antibody (BsAb) format due to its advantages of the conventional IgG structure. Production of FabscFv-Fc requires expression of three polypeptide chains, one light chain (LC), one heavy chain (HC) and a scFv fused to the Fc (scFvFc) at ...
Han Kee Ong, Ngan T B Nguyen, Jiawu Bi, Yuansheng Yang   +3 more
openaire   +2 more sources

A novel asymmetrical anti-HER2/CD3 bispecific antibody exhibits potent cytotoxicity for HER2-positive tumor cells

Journal of Experimental & Clinical Cancer Research, 2019
Background Human epidermal growth factor receptor 2 (HER2) is overexpressed in multiple cancers, which is associated with poor prognosis. Herceptin and other agents targeting HER2 have potent antitumor efficacy in patients with HER2-positive cancers ...
Shengnan Yu, Jing Zhang, Yongxiang Yan, Xudong Yao, Lijuan Fang, Hui Xiong, Yang Liu, Qian Chu, Pengfei Zhou, Kongming Wu   +9 more
doaj   +1 more source

Crystal structure of the N-benzyloxycarbonyl-Alanyl-Phenylalanyl-methyl ester: the importance of the H-bonding pattern [PDF]

, 2011
Large crystals of the methyl ester of the N-a-benzyloxycarbonyl protected Ala-Phe dipeptide (Z-AF-OMe) were obtained after the very slow evaporation of a solution of the corresponding carboxylic acid (Z-AF-OH) in methanol containing an excess of HCl. The
Alfonso, Ignacio, Bolte, Michael, Burguete, M. Isabel, Luis, Santiago V.   +3 more
core   +2 more sources

Antibody markup language (AbML) — a notation language for antibody-based drug formats and software for creating and rendering AbML (abYdraw)

mAbs, 2022
As interest in antibody-based drug development continues to increase, the biopharmaceutical industry has begun to focus on complex multi-specific antibodies (MsAbs) as an up-and-coming class of biologic that differ from natural monoclonal antibodies ...
James Sweet-Jones, Maham Ahmad, Andrew C.R. Martin   +2 more
doaj   +1 more source

Structural attributes for the recognition of weak and anomalous regions in coiled-coils of myosins and other motor proteins

BMC Research Notes, 2012
Background Coiled-coils are found in different proteins like transcription factors, myosin tail domain, tropomyosin, leucine zippers and kinesins. Analysis of various structures containing coiled-coils has revealed the importance of electrostatic and ...
Sunitha Margaret S, Nair Anu G, Charya Amol, Jadhav Kamalakar, Mukhopadhyay Sami, Sowdhamini Ramanathan   +5 more
doaj   +1 more source

Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5

Cell Discovery, 2023
SARS-CoV-2 Omicron subvariants have demonstrated extensive evasion from monoclonal antibodies (mAbs) developed for clinical use, which raises an urgent need to develop new broad-spectrum mAbs.
Yanqun Wang, An Yan, Deyong Song, Chuangchuang Dong, Muding Rao, Yuanzhu Gao, Ruxi Qi, Xiaomin Ma, Qiaoping Wang, Hongguang Xu, Hong Liu, Jing Han, Maoqin Duan, Shuo Liu, Xiaoping Yu, Mengqi Zong, Jianxia Feng, Jie Jiao, Huimin Zhang, Min Li, Beibei Yu, Yanxia Wang, Fanhao Meng, Xiaodan Ni, Ying Li, Zhenduo Shen, Baiping Sun, Xin Shao, Haifeng Zhao, Yanyan Zhao, Rui Li, Yanan Zhang, Guangying Du, Jun Lu, Chunna You, Hua Jiang, Lu Zhang, Lan Wang, Changlin Dou, Zheng Liu, Jincun Zhao   +40 more
doaj   +1 more source