Results 21 to 30 of about 1,953 (104)
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Central poststroke pain (CPSP), a neuropathic pain condition, is difficult to treat. Repetitive transcranial magnetic stimulation (rTMS) targeted to the primary motor cortex (M1) can alleviate the condition, but not all patients respond. We aimed to assess a promising alternative rTMS target, the secondary somatosensory cortex (S2),
Juhani Ojala +10 more
wiley +1 more source
BMC Research Notes, 2012 Background Coiled-coils are found in different proteins like transcription factors, myosin tail domain, tropomyosin, leucine zippers and kinesins. Analysis of various structures containing coiled-coils has revealed the importance of electrostatic and ...
Sunitha Margaret S +5 more
doaj +1 more source
mAbs, 2022 As interest in antibody-based drug development continues to increase, the biopharmaceutical industry has begun to focus on complex multi-specific antibodies (MsAbs) as an up-and-coming class of biologic that differ from natural monoclonal antibodies ...
James Sweet-Jones +2 more
doaj +1 more source
Cell Discovery, 2023 SARS-CoV-2 Omicron subvariants have demonstrated extensive evasion from monoclonal antibodies (mAbs) developed for clinical use, which raises an urgent need to develop new broad-spectrum mAbs.
Yanqun Wang +40 more
doaj +1 more source
Alanine zipper-like coiled-coil domains are necessary for homotypic dimerization of plant GAGA-factors in the nucleus and nucleolus. [PDF]
PLoS ONE, 2011 GAGA-motif binding proteins control transcriptional activation or repression of homeotic genes. Interestingly, there are no sequence similarities between animal and plant proteins.
Dierk Wanke +11 more
doaj +1 more source
Design Principles for Bispecific IgGs, Opportunities and Pitfalls of Artificial Disulfide Bonds
Antibodies, 2018 Bispecific antibodies (bsAbs) are antibodies with two binding sites directed at different antigens, enabling therapeutic strategies not achievable with conventional monoclonal antibodies (mAbs).
Lilach Vaks +9 more
doaj +1 more source
Design and Production of Bispecific Antibodies
Antibodies, 2019 With the current biotherapeutic market dominated by antibody molecules, bispecific antibodies represent a key component of the next-generation of antibody therapy.
Qiong Wang +7 more
doaj +1 more source
Engineering IgG-Like Bispecific Antibodies—An Overview
Antibodies, 2018 Monoclonal antibody therapeutics have proven to be successful treatment options for patients, which have various indications. Particularly in oncology, therapeutic concepts involving antibodies often rely on the so-called effector functions, such as ...
Simon Krah +3 more
doaj +1 more source
Angewandte Chemie, EarlyView.A nanopore composed of transmembrane peptides and a DNA scaffold that assists peptide assembly was constructed. By employing peptides containing the unnatural amino acid 2‐aminoisobutyric acid (Aib), which promotes loose packing between helices, a large‐diameter nanopore was achieved.
Zugui Peng +3 more
wiley +2 more sources
An antibody with Fab-constant domains exchanged for a pair of CH3 domains.
PLoS ONE, 2018 We have designed a complete antibody-like construct where the CH1 and Cκ domains are exchanged for a pair of the CH3 domains and efficient pairing of the heavy and light variable domain is achieved using "Knobs-into-Holes" strategy.
Gordana Wozniak-Knopp +6 more
doaj +1 more source