Results 41 to 50 of about 756,194 (303)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Numerical Analysis of End-Gas Autoignition and Pressure Oscillation in a Downsized SI Engine Using Large Eddy Simulation

Energies, 2019
Knock and super-knock are abnormal combustion phenomena in engines, however, they are hard to study comprehensively through optical experimental methods due to their inherent destructive nature.
Lijia Zhong, Changwen Liu
doaj   +1 more source

Proximal design in South African informal settlements: users as designers and the construction of the built environment and its fire risks

Tapuya, 2020
Informal settlements present a challenge for fire safety because they lack the regulation of building standards that have been central to reducing fire risks elsewhere.
Graham Spinardi, S.J. Cooper-Knock, David Rush   +2 more
doaj   +1 more source

Performance analysis of knock detectors [PDF]

, 2006
This paper examines performance of the knock detection technique typically used in engine control systems, and the margin for possible improvement. We introduce a knock signal model and obtain an analytical result for the associated receiver operating ...
Galtier, Frédéric, Vincent, François, Vingerhoeds, Rob A., Zadnik, Martin   +3 more
core  

An accurate measurement of electron beam induced displacement cross sections for single-layer graphene

, 2012
We present an accurate measurement and a quantitative analysis of electron-beam induced displacements of carbon atoms in single-layer graphene. We directly measure the atomic displacement ("knock-on") cross section by counting the lost atoms as a ...
Benner, G., Chuvilin, A., Eder, F., Eyhusen, S., Kaiser, U., Kotakoski, J., Krasheninnikov, A. V., Kurasch, S., Meyer, J. C., Park, H. -J., Roth, S., Skakalova, V.   +11 more
core   +1 more source

Cooper pair correlations and energetic knock-out reactions [PDF]

, 2012
Two-nucleon removal (or knock-out) reactions at intermediate energies are a developing tool for both nuclear spectroscopy and for the study of certain nucleon correlations in very exotic and some stable nuclei.
Simpson, E. C., Tostevin, J. A.
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Effect of fuel-air mixture dilution on knock intensity

Nihon Kikai Gakkai ronbunshu, 2016
Effect of fuel-air mixture diluted by inert gas on knock intensity was investigated by using a rapid compression and expansion machine. Dilution of fuel-air mixture decreased knock intensity.
Mitsuaki OHTOMO, Seiji YAMAMOTO, Hiroshi MIYAGAWA   +2 more
doaj   +1 more source

Efficient DNA knock-in using AAV-mediated delivery with 2-cell embryo CRISPR-Cas9 electroporation

Frontiers in Genome Editing, 2023
Recent advances in CRISPR-Cas genome editing technology have been instrumental in improving the efficiency to produce genetically modified animal models.
Daniel J. Davis, James F. McNew, Hailey Maresca-Fichter, Kaiwen Chen, Bhanu P. Telugu, Elizabeth C. Bryda, Elizabeth C. Bryda   +6 more
doaj   +1 more source