Results 61 to 70 of about 756,194 (303)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Experimental Investigation on Knock Characteristics from Pre-Chamber Gas Engine Fueled by Hydrogen

Energies
Hydrogen-fueled engines require large values of the excess air ratio in order to achieve high thermal efficiency. A low value of this coefficient promotes knocking combustion.
Ireneusz Pielecha, Filip Szwajca, Kinga Skobiej   +2 more
doaj   +1 more source

Porcine Knock-in Fibroblasts Expressing hDAF on α-1,3-Galactosyltransferase (GGTA1) Gene Locus [PDF]

Asian-Australasian Journal of Animal Sciences, 2012
The Galactose-α1,3-galactose (α1,3Gal) epitope is responsible for hyperacute rejection in pig-to-human xenotransplantation. Human decay-accelerating factor (hDAF) is a cell surface regulatory protein that serves as a complement inhibitor to protect self ...
Ji Woo Kim, Hye-Min Kim, Sang Mi Lee, Man-Jong Kang   +3 more
doaj   +1 more source

“Knock for knock” en contratos de fletamento: sus elementos centrales e interpretación judicial en el derecho comparado norteamericano e inglés

Boletín Mexicano de Derecho Comparado, 2021
La noción de “knock for knock” implica un régimen contractual que aplica un principio de distribución del riesgo y asignación de sus responsabilidades asociadas. Esta distribución se realiza sobre el criterio de que cada parte soporta sus propios riesgos,
Mariano Castillo
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

How Can a Punch Knock You Out?

Frontiers in Neurology, 2020
Several hypotheses have been put forth over time to explain how consciousness can be so rapidly lost, and then spontaneously regained, following mechanical head trauma.
Anders Hånell, Elham Rostami, Elham Rostami   +2 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Separation and identification of dominant mechanisms in double photoionization

, 2002
Double photoionization by a single photon is often discussed in terms of two contributing mechanisms, {\it knock-out} (two-step-one) and {\it shake-off} with the latter being a pure quantum effect.
A. Dalgarno, A. L. Stewart, D. Proulx, G. V. Marr, J. Colgan, J.-M. Rost, Jan-Michael Rost, P. Kustaanheimo, Peter Leszek Chocian, R. Abrines, S. J. Aarseth, T. Åberg, Tobias Schneider   +12 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Chemical, Natural, and Cultural Control of \u3ci\u3eHyadaphis Tataricae\u3c/i\u3e (Homoptera: Aphididae) on Honeysuckle [PDF]

, 2017
Hyadaphis tataricae is an aphid pest of honeysuckle relatively new to the Great Lakes and midwestern regions of North America. Feeding results in severly deformed terminals (witches\u27 brooms).
Dittl, T. G, Mahr, D. L
core   +2 more sources