Results 71 to 80 of about 756,194 (303)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Microscopics of meson degrees of freedom in nucleons and mesons in nuclei - what can be seen in the process of quasielastic knockout of mesons by high-energy electrons [PDF]

, 2002
Developed earlier concept of quasielastic knock out of pions from nucleons by high-energy electrons is propounded as a tool for checking microscopical model ($^3P_0$ - fluctuation) for decay of N to different channels $\pi+B$ and Preparata model of ...
A. B. Migdal, A. Gillitzer, A. V. Andreev, B. Desplanques, D. Allasia, D. O. Riska, E. G. Drukarev, E. Weigold, G. F. Chew, H. Tyren, I. T. Obukhovsky, I. T. Obukhovsky, I. T. Obukhovsky, I. T. Obukhovsky, J. Speth, J. Speth, K. Ayat, L. L. Sviridova, M. Guidal, M. P. Rekalo, N. P. Yudin, N. P. Yudin, O. F. Nemets, P. Brauel, P. G. Roos, R. A. Adelseck, R. Alzetta, S. Nozawa, S. S. Volkov, T.-Y. Saito, V. G. Neudachin, V. G. Neudachin, V. G. Neudachin, V. G. Neudatchin, V. G. Neudatchin, V. G. Neudatchin, V. G. Neudatchin, V. G. Neudatchin, Y. B. Dong, Ya. L. Glozman, Yu. B. Ivanov, Yu. F. Smirnov, Z.-Y. Zhang   +42 more
core   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes [PDF]

, 2017
Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease characterized by the loss of lower motor neurons. SBMA is caused by expansions of a polyglutamine tract in the gene coding for androgen receptor (AR).
Blaauw, Bert, Borgia, Doriana, Gomes Pereira, Marcelo, Lieberman, Andrew P., Maino, Eleonora, Malena, Adriana, Marchioretti, Caterina, Milioto, Carmelo, Pegoraro, Elena, Pennuto, Maria, Pennuto, Maria, Plebani, Mario, Polanco, Maria J., Sambataro, Fabio, Sambataro, Fabio, Sorar, Gianni, Soraru', Gianni, Venturini, Roberta, Vergani, Lodovica   +18 more
core   +3 more sources

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Knock Knock Who's There?

Ars Aequi, 2022
Wat te doen als je op Twitter door een anoniem profiel voor rotte vis wordt uitgemaakt? Het Nederlandse recht biedt verschillende mogelijkheden om identificerende gegevens te verkrijgen van internettussenpersonen. Maar hoe wordt de afweging met de bescherming van de persoonsgegevens van de anonymus gemaakt?
openaire   +3 more sources

Integration of CFD Methods into Concurrent Design of Internal Combustion Engine

Acta Polytechnica, 2004
This paper describes patterns of algorithms for different innovative levels of design at parametric, configuration and conceptual levels. They can be applied to Computer-aided Engine Design (CED).
M. Polášek, J. Macek, O. Vítek, K. Kozel   +3 more
doaj  

Single Proton Knock-Out Reactions from 24,25,26F

, 2003
The cross sections of the single proton knock-out reactions from 24F, 25F, and 26F on a 12C target were measured at energies of about 50 MeV/nucleon. Ground state populations of 6.6+-.9 mb, 3.8+-0.6 mb for the reactions 12C(24F,23O) and 12C(25F,24O) were
Baumann, R., Brown, B. A., Enders, J., Frank, N., Hansen, P. G., Heckman, P., Luther, B. A., Seitz, J., Stolz, A., Thoennessen, M., Tryggestad, E.   +10 more
core   +1 more source

Neuronal human BACE1 knock-in induces systemic diabetes in mice [PDF]

, 2016
Acknowledgements The authors thank S. Tammireddy (Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness, UK) for technical support with the lipidomics component. Funding We would like to thank R.
Dekeryte, Ruta, Delibegovic, Mirela, Doherty, Mary K., Koss, David, Mingarelli, Marco, Mody, Nimesh, Platt, Bettina, Pluci??ska, Kaja, Riedel, Gernot, Shearer, Kirsty, Welch, Andy, Whitfield, Phillip, Whitfield, Phillip D.   +12 more
core   +4 more sources

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source