Results 171 to 180 of about 2,060,910 (365)

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Tissue-specific changes of type 1 angiotensin II receptor and angiotensin-converting enzyme mRNA in angiotensinogen gene-knockout mice [PDF]

, 1999
Kouichi Tamura, Nobuyuki Yokoyama, Yoichi Sumida, Takayuki Fujita, Eiko Chiba, Nobuko Tamura, Shunichi KOBAYASHI, Minoru Kihara, K Murakami, Masatsuga Horiuchi, S Umemura   +10 more
openalex   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Calorie restriction delays spontaneous tumorigenesis in p53-knockout transgenic mice.

, 1994
Stephen D. Hursting, Susan N. Perkins, James M. Phang   +2 more
openalex   +1 more source

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

Aging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source

Loss of Dec1 inhibits alcohol-induced hepatic lipid accumulation and circadian rhythm disorder

BMC Molecular and Cell Biology
Chronic alcohol exposure increases liver damage such as lipid accumulation and hepatitis, resulting in hepatic cirrhosis. Chronic alcohol intake is known to disturb circadian rhythms in humans and animals.
Fuyuki Sato, Ujjal K. Bhawal, Kosuke Oikawa, Yasuteru Muragaki   +3 more
doaj   +1 more source

Impaired Hippocampal Representation of Space in CA1-Specific NMDAR1 Knockout Mice [PDF]

, 1996
Thomas J. McHugh, K. I. Blum, Joe Z. Tsien, Susumu Tonegawa, Matthew Wilson   +4 more
openalex   +1 more source

From Knockout Mice to Knockout Rats [PDF]

Neurosurgery, 2003
openaire   +2 more sources

Dissemination of Chlamydia trachomatis chronic genital tract infection in gamma interferon gene knockout mice [PDF]

, 1997
T W Cotter, Kyle H. Ramsey, Gurwattan S. Miranpuri, Christoffer E. Poulsen, G I Byrne   +4 more
openalex   +1 more source

Skin calcium deposits in primary familial brain calcification: A novel potential biomarker

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Primary Familial Brain Calcification (PFBC) is a rare neurodegenerative disorder characterized by small vessel calcifications in the basal ganglia. PFBC is caused by pathogenic variants in different genes and its physiopathology is still largely unknown. Skin vascular calcifications have been detected in single PFBC cases, suggesting
Aron Emmi, Giulia Bonato, Aleksandar Tushevski, Cinzia Bertolin, Francesco Cavallieri, Andrea Porzionato, Angelo Antonini, Leonardo Salviati, Miryam Carecchio   +8 more
wiley   +1 more source