Results 171 to 180 of about 2,419,748 (303)

Dpp6 knockout mice exhibit increased ethanol conditioned place preference and acute ethanol-induced anxiolytic behavior. [PDF]

Alcohol Clin Exp Res (Hoboken)
Hernández M, Barkley-Levenson AM.
europepmc   +1 more source

Perceived Impacts and Predictors of Cannabis Products Used by Patients with Rheumatologic Conditions in Alberta, Canada: A Multivariable Analysis of Cross‐Sectional Survey Data

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize cannabis product choices (cannabinoid content and formulation) among patients with rheumatologic conditions and their associations with patient factors, patient‐reported perceived side effects, and positive impacts.
Susan Zhang, Samuel A.J. Lowe, Frank Sun, Allyson Jones, Tarek Turk, Joanne Olson, Pauline Paul, Shelby Yamamoto, Linda Kolewaski, Elaine Yacyshyn, Cheryl A. Sadowski   +10 more
wiley   +1 more source

Insulin Deficiency Exacerbates Muscle Atrophy and Osteopenia in Chrebp Knockout Mice. [PDF]

Int J Mol Sci
Ushiroda C, Ito M, Yamamoto-Wada R, Deguchi K, Hidaka S, Imaizumi T, Seino Y, Suzuki A, Yabe D, Iizuka K.   +9 more
europepmc   +1 more source

Upregulated TRPM1 is associated with apoptosis in Rs1 knockout mice and in ARPE19 cells through increased intracellular calcium. [PDF]

Sci Rep
Wang W, Liu J, Jin X, Qiu R, Yang M, Yao S, Liu G, Qin M, Lei B.   +8 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Mas Knockout Mice Present Altered Behavioral and Neuroendocrine Coping Responses to Chronic Unpredictable Stress. [PDF]

Mol Neurobiol
Gonçalves SCA, da Silveira Silva A, Nogueira BKO, Mourão FAG, Fontes MAP, Bader M, Santos RAS, Campagnole-Santos MJ, Kangussu LM.   +8 more
europepmc   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Rapid generation of prion disease models using AAV-delivered PrP variants in knockout mice. [PDF]

Brain Pathol
San-Juan-Ansoleaga M, Fernández-Muñoz E, Charco JM, Vidal E, Herrero-Martínez D, Galarza-Ahumada J, Sampedro-Torres-Quevedo C, Giler S, Geijo M, González-Aseguinolaza G, Eraña H, Castilla J.   +11 more
europepmc   +1 more source

Spatiotemporal Drug Delivery via a Neonatal Spinal Cord ECM Hydrogel for Biomimetic Microenvironment Remodeling After Spinal Cord Injury

Advanced Functional Materials, EarlyView.
A biomimetic hydrogel derived from neonatal spinal cord ECM (DNSCM) delivers LAMB2 protein and ISP peptide to remodel the inhibitory injury microenvironment. The system sustains drug release, upregulates pro‐regenerative LAMB2, downregulates inhibitory CSPG, and promotes axonal regeneration.
Shiyu Fu, Liangchao Du, Runlin Wen, Kai Zhang, Yu Zhou, Wanrong Ma, Zhiquan Yang, Dingyang Liu, Xing Li   +8 more
wiley   +1 more source

Strain-specific pathogenicity and antibody-dependent enhancement of dengue virus infection in <i>Ifnar1-Ifngr1</i> double-knockout mice. [PDF]

J Gen Virol
Hishiki T, Virhuez-Mendoza M, Sakai Y, Uda A, Ozono S, Sato Y, Machiya S, Sato K, Utsui Y, Tajima S, Lim CK, Hotta A, Kuroda Y, Yamamoto T, Takahashi Y, Suzuki T, Watashi K, Maeda K.   +17 more
europepmc   +1 more source