Leigh Syndrome Pathomechanism Involves Region-Specific Innate Immune Activation in Ndufs4 Knockout Mice. [PDF]
Cell Mol NeurobiolFouché BR +3 more
europepmc +1 more source
Tissue‐Adhesive Fabric‐Based Bioelectronics for Wearable and Implantable Applications
Advanced Functional Materials, EarlyView.An implantable and wearable bioelectronic textile (iTextile) is introduced as a unified platform bridging wearable and implantable systems. By integrating a self‐healing polymer, stretchable silk fabric, conductive composite electrodes, and an adhesive hydrogel, the platform enables conformal, stable interfacing with soft tissues. The iTextile supports
Soojung An +7 more
wiley +1 more source
Early fibrotic gene activation precedes structural remodeling in the heart of cardiac myosin binding protein-C knockout mice. [PDF]
Physiol GenomicsTurner KL +2 more
europepmc +1 more source
Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines
Advanced Functional Materials, EarlyView.Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang +13 more
wiley +1 more source
Acute HSV-1 Ocular Infection Is Impaired in KLF15 Knockout Mice but Stress-Induced Reactivation from Latency Is Prolonged in Male KLF15 Knockout Mice. [PDF]
PathogensHarrison KS, Jones C.
europepmc +1 more source
Advanced Functional Materials, EarlyView.A bio‐inspired biopolymeric implantable drug delivery platform enables localized and sustained release of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38) in solid tumor treatment. The three‐dimensional (3D) structured crosslinked‐chitosan implants are fabricated via 3D‐printed molds and provide drug release over 3 months, significantly inhibiting tumor growth ...
Mercedes Lozano‐Garcia +12 more
wiley +1 more source
Unveiling Diagnostic Biomarkers in Autism: A Comparative Proteome Analysis of <i>CNTNAP2</i> Knockout Mice and Human ASD Patients. [PDF]
BiomoleculesKim A +8 more
europepmc +1 more source
Advanced Functional Materials, EarlyView.A polymerizable deep eutectic solvent is reinforced with tannic acid‐modified cellulose nanofibers to construct a hierarchical dynamic eutectogel network. Synergistic covalent and reversible interactions impart ultrahigh stretchability, high ionic conductivity, broad temperature tolerance, self‐healing, and strong adhesion, enabling robust wearable ...
Huang Wu +11 more
wiley +1 more source
Vincristine-induced brain toxicity is reduced with prevention of peripheral axon degeneration in Sarm1 knockout mice. [PDF]
Acta Neuropathol CommunYeung J +10 more
europepmc +1 more source
A 3D Human Neuron‐on‐Chip Platform to Monitor Neuronal Injury Responses
Advanced Healthcare Materials, EarlyView.This study presents a novel 3D Neuron‐on‐Chip model that can maintain human PSC‐derived excitatory prefrontal cortex neurons in 3D hydrogels and can be used to monitor neuronal injury responses over time. Results show injury‐induced acute neuronal excitotoxicity, declining neuronal connectivity, and the activation of a neurodegenerative, SASP‐like ...
Ruiping Tang +16 more
wiley +1 more source