A fully defined GelMA‐based ECM platform integrates tunable tissue‐relevant stiffness with laminin–entactin biochemical supplementation to support mouse small intestinal organoid growth. Coordinated control of mechanical and biochemical cues promotes robust proliferation, budding morphogenesis, differentiation, and passaging, providing a reproducible ...
Junyi Liu +3 more
wiley +1 more source
Electromotility can be disassociated from gating charge movement in outer hair cells of conditional alpha2 spectrin knockout mice. [PDF]
Bai JP +10 more
europepmc +1 more source
Phenotype Differences Between ATP13A2 Heterozygous and Knockout Mice Across Aging. [PDF]
Croucher K +12 more
europepmc +1 more source
ETP-specific-knockout mice reveal endotrophin as a key regulator of kidney fibrosis in ischemia-reperfusion injury models. [PDF]
Kim DS +13 more
europepmc +1 more source
Is the FEO Food-Entrainable? Reexamining the Classic Fred Stephan Experiment Using Canonical-Clock-Less <i>Period 1/2/3</i> Triple Knockout Mice. [PDF]
Taufique SKT +4 more
europepmc +1 more source
Wheat-Based Protein Slows Disease Progression in Pkd1 Knockout Mice. [PDF]
Sedaka R +14 more
europepmc +1 more source
Activation of GABA transmission by clonazepam reverses the autistic-like phenotypes of the Cav3.2 knockout mice. [PDF]
Liang SF +6 more
europepmc +1 more source
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Impact of Knockout Mice in Toxicology
Critical Reviews in Toxicology, 1997Knockout mice obtained by homologous recombination technology may be valuable tools for in vivo investigations in toxicopathogenesis. A short review is given on the phenotype of mice with distinct deletions of cytokines and related genes. The application of these mice in pharmacological and toxicological research is discussed, with emphasis in ...
Bernhard Ryffel
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The xeroderma pigmentosum group A correcting (XPA) gene encodes a DNA binding zinc-finger protein that recognizes DNA damage. As such the XPA protein participates in the initial step of the process of nucleotide excision repair. The multicomponent nucleotide excision repair pathway is one of the most thoroughly studied mechanisms that defends both ...
de Vries, A, van Steeg, H
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Knockout Mice in Xenobiotic Metabolism
Drug Metabolism Reviews, 2003Mice in which genes for drug metabolizing enzymes have been deleted or inactivated have great potential to further our understanding of the functions of these enzymes and their role in toxicology a...
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