Results 211 to 220 of about 773,972 (346)

17β-Estradiol strongly inhibits azoxymethane/dextran sulfate sodium-induced colorectal cancer development in Nrf2 knockout male mice

, 2020
Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Joo Hee Son, Jeong Eun Yu, Eun Shin, Ha-Na Lee, Do-Hee Kim, Young‐Joon Surh   +9 more
openalex   +1 more source

Associations of Sleep and Shift Work with Osteoarthritis Risk

Arthritis Care &Research, Accepted Article.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships between circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000‐person cohort, we evaluated associations between sleep duration, sleeplessness/insomnia, and ...
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Behavioral Balance in Tryptophan Turmoil: Regional Metabolic Rewiring in Kynurenine Aminotransferase II Knockout Mice. [PDF]

Cells
Szabó Á, Galla Z, Spekker E, Martos D, Szűcs M, Fejes-Szabó A, Fehér Á, Takeda K, Ozaki K, Inoue H, Yamamoto S, Monostori P, Toldi J, Ono E, Vécsei L, Tanaka M.   +15 more
europepmc   +1 more source

Macrophage Adipose Triglyceride Lipase Deficiency Attenuates Atherosclerotic Lesion Development in Low-Density Lipoprotein Receptor Knockout Mice [PDF]

, 2010
Bart Lammers, Prakash G. Chandak, Elma Aflaki, Gijs H.M. van Puijvelde, Branislav Radović, Reeni B. Hildebrand, Illiana Meurs, Ruud Out, Johan Kuiper, Theo J.C. van Berkel, Dagmar Kolb, Guenter Haemmerle, Rudolf Zechner, Sanja Levak‐Frank, Miranda Van Eck, Dagmar Kratky   +15 more
openalex   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Early Supplementation with Branched-Chain Amino Acids Ameliorates Lipid Retention in Aortic Valves of ApoE-Knockout Mice. [PDF]

Int J Mol Sci
Shishkova D, Kanonykina A, Kondratiev E, Tyurina A, Morozova A, Poddubnyak A, Sinitskaya A, Sinitsky M, Markova V, Lazebnaya A, Bogdanov L, Stepanov A, Agalaryan S, Kutikhin A.   +13 more
europepmc   +1 more source

Using ASMase Knockout Mice to Model Human Diseases

, 2013
Guoqiang Hua, Richard Kolesnick
openalex   +2 more sources

Triple selectin knockout (ELP-/-) mice fail to develop OVA-induced acute asthma phenotype. [PDF]

, 2011
Ena Ray Banerjee
openalex   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Differences between therapeutic mechanisms of resmetirom and semaglutide against MASH in western diet-fed MC4R-knockout mice. [PDF]

Sci Rep
Sugawara T, Hitaka K, Matsumoto M, Nakamura S, Kobayashi R, Kandori H, Nio Y.   +6 more
europepmc   +1 more source