Results 61 to 70 of about 1,667,987 (261)

Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice [PDF]

, 2013
International efforts to test gene function in the mouse by the systematic knockout of each gene are creating many lines in which embryonic development is compromised.
Mohun, Timothy, Richard Baldock, Andrew J. Copp, Houart, Corinne, Hurles, Matt E., Hemberger, Myriam, Wolfgang Weninger, James C. Smith, Adams, David J, Shoumo Bhattacharya, Bhattacharya, Shoumo, Corinne Houart, Hurles, Matt E, Weninger, W, Weninger, Wolfgang, Timothy Mohun, Tom Weaver, Adams, David J., Smith, James C., Baldock, Richard, Weaver, T, David J. Adams, Adams, DJ, Houart, C, Baldock, R, Mohun, T, Hemberger, M, Copp, Andrew J., Weaver, Tom, Bhattacharya, S, Smith, JC, Elizabeth Robertson, Robertson, E, Copp, Andrew J, Myriam Hemberger, Copp, AJ, Robertson, Elizabeth, Hurles, ME, Matt E. Hurles   +38 more
core   +1 more source

Beneficial Effect of Mas Receptor Deficiency on Vascular Cognitive Impairment in the Presence of Angiotensin II Type 2 Receptor

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundThe classical renin‐angiotensin system is known as the angiotensin (Ang)‐converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline.
Akinori Higaki, Masaki Mogi, Jun Iwanami, Li‐Juan Min, Hui‐Yu Bai, Bao‐Shuai Shan, Masayoshi Kukida, Toshifumi Yamauchi, Kana Tsukuda, Harumi Kan‐no, Shuntaro Ikeda, Jitsuo Higaki, Masatsugu Horiuchi   +12 more
doaj   +1 more source

Interaction of Tau, IL-6 and mitochondria on synapse and cognition following sevoflurane anesthesia in young mice

Brain, Behavior, & Immunity - Health, 2020
Tau phosphorylation is associated with cognitive impairment in young mice. However, the underlying mechanism and targeted interventions remain mostly unknown.
Jie Zhang, Yuanlin Dong, Lining Huang, Xiaoming Xu, Feng Liang, Sulpicio G. Soriano, Yiying Zhang, Zhongcong Xie   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Transcriptional Profiling of Luteinizing Hormone Receptor-Deficient Mice Before and after Testosterone Treatment Provides Insight into the Hormonal Control of Postnatal Testicular Development and Leydig Cell Differentiation [PDF]

, 2010
Luteinizing hormone (LH) is a key regulator of male fertility through its effects on testosterone secretion by Leydig cells. Transcriptional control of this is, however, currently poorly understood.
Affara, Nabeel, Abel, M, Ellis, Peter J.I., Dunmore, B., Bauer, Johann W., Griffin, Darren K.   +5 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice [PDF]

, 2011
Insulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease).
Burgess, Laura A, Howlett, David R, Meakin, PJ, Vaanholt, Lobke M, Hamilton, DL, Vaanholt, Lobke M., Judy Latcham, Burgess, Laura A., Alison D. McNeilly, Burgess, LA, Michael L.J. Ashford, D. Lee Hamilton, Lobke M. Vaanholt, Kirsten A. Bannon, Ashford, MLJ, David R. Howlett, Speakman, John R, McNeilly, Alison D, Alex J. Harper, John R. Speakman, Ashford, Michael L J, Speakman, John R., Gallagher, J, Hamilton, David Lee, McNeilly, Alison D.; id_orcid, Hussain, Ishrut, Hamilton, D. Lee, Meakin, Paul J.; id_orcid, Latcham, J, Harper, Alex J, Bannon, KA, McNeilly, AD, Jennifer Gallagher, Latcham, Judy, Howlett, DR, Ashford, Michael L. J.; id_orcid, Vaanholt, LM, Hussain, I, Gallagher, Jennifer, Harper, Alex J., Bannon, Kirsten A., Paul J. Meakin, Bannon, Kirsten A, Ishrut Hussain, Harper, AJ, Meakin, Paul J, Laura A. Burgess, Howlett, David R., Speakman, JR   +48 more
core   +1 more source

IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors. [PDF]

PLoS ONE, 2015
Antigen-specific IgG antibodies, passively administered to mice or humans together with large particulate antigens like erythrocytes, can completely suppress the antibody response against the antigen.
Joakim J E Bergström, Birgitta Heyman
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Different Forms of AMPA Receptor Mediated LTP and Their Correlation to the Spatial Working Memory Formation

Frontiers in Molecular Neuroscience, 2017
Spatial working memory (SWM) and the classical, tetanus-induced long-term potentiation (LTP) at hippocampal CA3/CA1 synapses are dependent on L-α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) containing GluA1 subunits as demonstrated ...
Derya R. Shimshek, Thorsten Bus, Thorsten Bus, Bettina Schupp, Vidar Jensen, Verena Marx, Verena Marx, Liliana E. Layer, Liliana E. Layer, Georg Köhr, Georg Köhr, Rolf Sprengel, Rolf Sprengel   +12 more
doaj   +1 more source