Results 51 to 60 of about 2,419,748 (303)

Lack of Inducible Nitric Oxide Synthase Prevents Lipid-Induced Skeletal Muscle Insulin Resistance Without Attenuating Cytokine Level

Journal of Pharmacological Sciences, 2011
.: We examined whether deletion of inducible nitric oxide synthase (iNOS) could prevent lipid infusion-induced insulin resistance in iNOS-knockout and wild-type mice with the in vivo euglycemic-hyperinsulinemic clamp technique. Plasma NO metabolites were
Hye-Na Cha, Seung Eun Song, Yong-Woon Kim, Jong-Yeon Kim, Kyu-Chang Won, So-Young Park   +5 more
doaj   +1 more source

The NADPH Oxidase Isoform 1 Contributes to Angiotensin II-Mediated DNA Damage in the Kidney

Antioxidants, 2020
In higher concentrations, the blood pressure regulating hormone angiotensin II leads to vasoconstriction, hypertension, and oxidative stress by activating NADPH oxidases which are a major enzymatic source of reactive oxygen species (ROS).
Anna Zimnol, Nora Spicker, Ronja Balhorn, Katrin Schröder, Nicole Schupp   +4 more
doaj   +1 more source

Autism-related behavioral abnormalities in synapsin knockout mice

Behavioural Brain Research, 2013
Highlights ► Deletion of Syn isoforms widely impairs social behavior. ► SynII−/− mice display impaired social interaction, novelty and recognition. ► SynI−/− and SynII−/− mice are characterized by increased social dominance. ► Young and adult SynI−/− and
B. Greco, Francesca Managò, V. Tucci, H. Kao, F. Valtorta, F. Benfenati   +5 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging‐Related Muscle Weakness in Male Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background The activation of AT2 (angiotensin II type 2 receptor ) and Mas receptor by angiotensin II and angiotensin‐(1‐7), respectively, is the primary process that counteracts activation of the canonical renin‐angiotensin system (RAS).
Hikari Takeshita, Koichi Yamamoto, Masaki Mogi, Yu Wang, Yoichi Nozato, Taku Fujimoto, Serina Yokoyama, Kazuhiro Hongyo, Futoshi Nakagami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Masatsugu Horiuchi, Hiromi Rakugi   +14 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Heterozygous Mylk3 Knockout Mice Partially Recapitulate Human DCM With Heterozygous MYLK3 Mutations

Frontiers in Physiology, 2019
Backgrounds: Recent studies identified heterozygous variants in MYLK3 gene that encodes cardiac myosin light chain kinase (cMLCK) are related to familial dilated cardiomyopathy (DCM) for the first time. Autosomal dominant traits suggest that pathogenesis
Carson L. Tougas, Tabor Grindrod, Lawrence X. Cai, Fariz F. Alkassis, Hideko Kasahara   +4 more
doaj   +1 more source

Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice. [PDF]

PLoS ONE, 2012
Evidence suggests that selenium has cancer preventive properties that are largely mediated through selenoproteins. Our previous observations demonstrated that targeted down-regulation of the 15 kDa selenoprotein (Sep15) in murine colon cancer cells ...
Petra A Tsuji, Bradley A Carlson, Salvador Naranjo-Suarez, Min-Hyuk Yoo, Xue-Ming Xu, Dmitri E Fomenko, Vadim N Gladyshev, Dolph L Hatfield, Cindy D Davis   +8 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

An atlas of genetic influences on osteoporosis in humans and mice

Nature Genetics, 2018
Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative ultrasound in 426,824 individuals, identifying 518 genome-wide significant loci
John A. Morris, J. Kemp, Scott E. Youlten, Laetitia Laurent, John G Logan, R. Chai, Nicholas A. Vulpescu, Vincenzo Forgetta, A. Kleinman, Sindhu T. Mohanty, C. M. Sergio, J. Quinn, L. Nguyen-Yamamoto, Aimée-Lee Luco, Jinchu Vijay, Marie-Michelle Simon, A. Pramatarova, C. Medina-Gomez, K. Trajanoska, Elena J Ghirardello, N. Butterfield, Katharine F. Curry, V. D. Leitch, Penny C Sparkes, Anne-Tounsia Adoum, Naila S. Mannan, Davide Komla-Ebri, A. Pollard, Hannah F Dewhurst, Thomas A. D. Hassall, Michael-John G. Beltejar, Michelle Babak Adam Robert K. Katarzyna Sarah L. Pierre Nic Agee Alipanahi Auton Bell Bryc Elson Fontanillas F, M. Agee, B. Alipanahi, A. Auton, R. Bell, K. Bryc, S. Elson, P. Fontanillas, N. Furlotte, J. McCreight, K. Huber, N. Litterman, M. McIntyre, J. Mountain, E. Noblin, C. Northover, S. Pitts, J. Sathirapongsasuti, O. Sazonova, J. Shelton, S. Shringarpure, C. Tian, J. Tung, V. Vacic, C. Wilson, Douglas J. Adams, S. Vaillancourt, S. Kaptoge, P. Baldock, C. Cooper, J. Reeve, E. Ntzani, E. Evangelou, C. Ohlsson, D. Karasik, F. Rivadeneira, D. Kiel, J. Tobias, C. Gregson, N. Harvey, E. Grundberg, D. Goltzman, D. J. Adams, C. Lelliott, D. Hinds, C. Ackert-Bicknell, Y. Hsu, Matthew T. Maurano, P. Croucher, G. Williams, J. Bassett, David M. Evans, J. Richards   +83 more
semanticscholar   +1 more source