Results 31 to 40 of about 2,419,748 (303)
Analysis of microRNA knockouts in mice [PDF]
Human Molecular Genetics, 2010 MicroRNAs (miRNAs) are small noncoding RNAs that act as potent regulators of gene expression. The discovery of miRNAs with specific temporal and spatial expression patterns revealed a hidden layer of post-transcriptional gene regulation. Furthermore, differential expression of miRNAs during disease progression identified miRNAs as relevant candidate ...
Chong Y, Park +2 more
openaire +2 more sources
Molecular Therapy: Methods & Clinical Development, 2021 Inducible conditional knockout mice are important tools for studying gene function and disease therapy, but their generation is costly and time-consuming.
Dan Xiao +10 more
doaj +1 more source
Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice
International Journal of Hypertension, 2012 To elucidate roles of heme oxygenase-1 (HO-1) in cardiovascular system, we have analyzed one-year-old HO-1-knockout mice. Homozygous HO-1-knockout mice had severe aortitis and coronary arteritis with mononuclear cellular infiltration and fatty streak ...
Kazunobu Ishikawa +2 more
doaj +1 more source
Production of Knockout Mice using CRISPR/Cas9 in FVB Strain
Journal of Animal Reproduction and Biotechnology, 2015 KO mice provide an excellent tool to determine roles of specific genes in biomedical filed. Traditionally, knockout mice were generated by homologous recombination in embryonic stem cells.
Hee Sook Bae, Soo Jin Lee , Ok Jae Koo
doaj +1 more source
Neuron, 1996 Brain-derived neurotrophic factor (BDNF) is expressed at high levels in hippocampal neurons, and its expression is modulated by neural activity. Knockout mice can be used to study the roles of molecules like BDNF in synaptic plasticity with more ...
Susan L. Patterson +5 more
semanticscholar +1 more source
Cdk2 Knockout Mice Are Viable [PDF]
Current Biology, 2003 Cyclin-dependent kinases (Cdks) and their cyclin regulatory subunits control cell growth and division. Cdk2/cyclin E complexes are thought to be required because they phosphorylate the retinoblastoma protein and drive cells through the G1/S transition into the S phase of the cell cycle.
Berthet, Cyril +4 more
openaire +2 more sources
The effect of lubricin on the gliding resistance of mouse intrasynovial tendon.
PLoS ONE, 2013 The purpose of this study was to investigate the role of lubricin on the gliding resistance of intrasynovial tendons by comparing lubricin knockout, heterozygous, and wild type mice.
Masanori Hayashi +6 more
doaj +1 more source
Rab11a is required for apical protein localisation in the intestine
Biology Open, 2014 The small GTPase Rab11 plays an important role in the recycling of proteins to the plasma membrane as well as in polarised transport in epithelial cells and neurons. We generated conditional knockout mice deficient in Rab11a.
Tomoaki Sobajima +10 more
doaj +1 more source
Neural Plasticity, 2023 Several microRNAs (miRNAs), including miR-23 and miR-27a have been reportedly involved in regulating myelination in the central nervous system. Although miR-23 and miR-27a form clusters in vivo and the clustered miRNAs are known to perform complementary ...
Yuji Tsuchikawa +8 more
doaj +1 more source
Integrins in vascular development
Brazilian Journal of Medical and Biological Research, 1999 Many growth factors and their protein kinase receptors play a role in regulating vascular development. In addition, cell adhesion molecules, such as integrins and their ligands in the extracellular matrix, play important roles in the adhesion, migration,
R.O. Hynes +2 more
doaj +1 more source