Results 31 to 40 of about 1,667,987 (261)

Rab11a is required for apical protein localisation in the intestine

Biology Open, 2014
The small GTPase Rab11 plays an important role in the recycling of proteins to the plasma membrane as well as in polarised transport in epithelial cells and neurons. We generated conditional knockout mice deficient in Rab11a.
Tomoaki Sobajima, Shin-ichiro Yoshimura, Tomohiko Iwano, Masataka Kunii, Masahiko Watanabe, Nur Atik, Sotaro Mushiake, Eiichi Morii, Yoshihisa Koyama, Eiji Miyoshi, Akihiro Harada   +10 more
doaj   +1 more source

Establishment and identification of a mouse model of Fscb/Cabyr double gene knockout

Di-san junyi daxue xuebao, 2020
Objective To construct a mouse model of targeted knockout of Fscb/Cabyr dual genes by using the CRISPR/Cas9 system, in order to found a basis for the study of the role of FSCB and CABYR protein complexe in sperm flagellum movement and capacitation ...
LI Zhongtai, LI Zhongtai, LI Yanfeng, LIU Jinyi   +3 more
doaj   +1 more source

Ovol2, a zinc finger transcription factor, is dispensable for spermatogenesis in mice

Reproductive Biology and Endocrinology, 2019
Ovol2, a mouse homolog of Drosophila ovo, was identified as a zinc finger transcription factor predominantly expressed in testis. However, the function of Ovol2 in postnatal male germ cell development remains enigmatic. Here, we firstly examined the mRNA
Jin Zhang, Juan Dong, Weibing Qin, Congcong Cao, Yujiao Wen, Yunge Tang, Shuiqiao Yuan   +6 more
doaj   +1 more source

Receptor Activity Modifying Protein RAMP Sub-Isoforms and Their Functional Differentiation, Which Regulates Functional Diversity of Adrenomedullin

Biology, 2022
AM knockout (AM-/-) and RAMP2 knockout (RAMP2-/-) proved lethal for mice due to impaired embryonic vascular development. Although most vascular endothelial cell-specific RAMP2 knockout (E-RAMP2-/-) mice also died during the perinatal period, a few E ...
Takayuki Shindo, Megumu Tanaka, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Takayuki Sakurai   +5 more
doaj   +1 more source

Pdgfrα-Cre mediated knockout of the aryl hydrocarbon receptor protects mice from high-fat diet induced obesity and hepatic steatosis.

PLoS ONE, 2020
Aryl hydrocarbon receptor (AHR) agonists such as dioxin have been associated with obesity and the development of diabetes. Whole-body Ahr knockout mice on high-fat diet (HFD) have been shown to resist obesity and hepatic steatosis.
Francoise A Gourronc, Kathleen R Markan, Katarina Kulhankova, Zhiyong Zhu, Ryan Sheehy, Dawn E Quelle, Leonid V Zingman, Zoya B Kurago, James A Ankrum, Aloysius J Klingelhutz   +9 more
doaj   +1 more source

The roles of P2Y2 purinergic receptors in osteoblasts and mechanotransduction. [PDF]

PLoS ONE, 2014
We previously demonstrated, using osteoblastic MC3T3-E1 cells, that P2Y2 purinergic receptors are involved in osteoblast mechanotransduction. In this study, our objective was to further investigate, using a knockout mouse model, the roles of P2Y2 ...
Yanghui Xing, Yan Gu, James J Bresnahan, Emmanuel M Paul, Henry J Donahue, Jun You   +5 more
doaj   +1 more source

Selenoprotein F Knockout Caused Glucose Metabolism Disorder in Young Mice by Disrupting Redox Homeostasis

Antioxidants, 2022
Selenoprotein F (SELENOF) might play an important role in maintaining human health since an increasing number of studies have linked SELENOF deficiency to various pathologies such as cancer and neurodegeneration.
Min Li, Yun Zhang, Jun Zhou, Hongmei Liu
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Dental and periodontal phenotype in sclerostin knockout mice. [PDF]

, 2014
Sclerostin is a Wnt signalling antagonist that controls bone metabolism. Sclerostin is expressed by osteocytes and cementocytes; however, its role in the formation of dental structures remains unclear.
Heimel, Patrick, Michaela Kneissel, Patrick Heimel, Schwarze, Uwe, Gruber, Reinhard, Dobsak, Toni, Toni Dobsak, Reinhard Gruber, Schwarze, Uwe Y, Uwe Y Schwarze, Dieter D Bosshardt, Ulrike Kuchler, Bosshardt, Dieter, Kneissel, Michaela, Kuchler, Ulrike, Dosak, Toni   +15 more
core   +2 more sources

Lack of Inducible Nitric Oxide Synthase Prevents Lipid-Induced Skeletal Muscle Insulin Resistance Without Attenuating Cytokine Level

Journal of Pharmacological Sciences, 2011
.: We examined whether deletion of inducible nitric oxide synthase (iNOS) could prevent lipid infusion-induced insulin resistance in iNOS-knockout and wild-type mice with the in vivo euglycemic-hyperinsulinemic clamp technique. Plasma NO metabolites were
Hye-Na Cha, Seung Eun Song, Yong-Woon Kim, Jong-Yeon Kim, Kyu-Chang Won, So-Young Park   +5 more
doaj   +1 more source