Rab11a is required for apical protein localisation in the intestine
Biology Open, 2014 The small GTPase Rab11 plays an important role in the recycling of proteins to the plasma membrane as well as in polarised transport in epithelial cells and neurons. We generated conditional knockout mice deficient in Rab11a.
Tomoaki Sobajima +10 more
doaj +1 more source
Establishment and identification of a mouse model of Fscb/Cabyr double gene knockout
Di-san junyi daxue xuebao, 2020 Objective To construct a mouse model of targeted knockout of Fscb/Cabyr dual genes by using the CRISPR/Cas9 system, in order to found a basis for the study of the role of FSCB and CABYR protein complexe in sperm flagellum movement and capacitation ...
LI Zhongtai +3 more
doaj +1 more source
Terminal differentiation of adult hippocampal progenitor cells is a step functionally dissociable from proliferation and is controlled by Tis21, Id3 and NeuroD2 [PDF]
, 2017 Cell proliferation and differentiation are interdependent processes. Here, we have asked to what extent the two processes of neural progenitor cell amplification and differentiation are functionally separated.
Daniele Saraulli +9 more
core +2 more sources
Integrins in vascular development
Brazilian Journal of Medical and Biological Research, 1999 Many growth factors and their protein kinase receptors play a role in regulating vascular development. In addition, cell adhesion molecules, such as integrins and their ligands in the extracellular matrix, play important roles in the adhesion, migration,
R.O. Hynes +2 more
doaj +1 more source
The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis. [PDF]
, 2016 The mitochondrial translocator protein (TSPO) has been implicated in CNS diseases. Here, we sought to determine the specific role of TSPO in experimental autoimmune encephalomyelitis (EAE), the most studied animal model of multiple sclerosis (MS).
Chechneva, Olga +3 more
core +1 more source
Deletion of Gpr27 in vivo reduces insulin mRNA but does not result in diabetes. [PDF]
, 2020 Gpr27 is a highly conserved, orphan G protein coupled receptor (GPCR) previously implicated in pancreatic beta cell insulin transcription and glucose-stimulated insulin secretion in vitro. Here, we characterize a whole-body mouse knockout of Gpr27. Gpr27
Chopra, Deeksha G +4 more
core
The roles of P2Y2 purinergic receptors in osteoblasts and mechanotransduction. [PDF]
PLoS ONE, 2014 We previously demonstrated, using osteoblastic MC3T3-E1 cells, that P2Y2 purinergic receptors are involved in osteoblast mechanotransduction. In this study, our objective was to further investigate, using a knockout mouse model, the roles of P2Y2 ...
Yanghui Xing +5 more
doaj +1 more source
Biology, 2022 AM knockout (AM-/-) and RAMP2 knockout (RAMP2-/-) proved lethal for mice due to impaired embryonic vascular development. Although most vascular endothelial cell-specific RAMP2 knockout (E-RAMP2-/-) mice also died during the perinatal period, a few E ...
Takayuki Shindo +5 more
doaj +1 more source
Ovol2, a zinc finger transcription factor, is dispensable for spermatogenesis in mice
Reproductive Biology and Endocrinology, 2019 Ovol2, a mouse homolog of Drosophila ovo, was identified as a zinc finger transcription factor predominantly expressed in testis. However, the function of Ovol2 in postnatal male germ cell development remains enigmatic. Here, we firstly examined the mRNA
Jin Zhang +6 more
doaj +1 more source
Estrogen Protects the Female Heart from Ischemia/Reperfusion Injury through Manganese Superoxide Dismutase Phosphorylation by Mitochondrial p38β at Threonine 79 and Serine 106. [PDF]
, 2016 A collective body of evidence indicates that estrogen protects the heart from myocardial ischemia/reperfusion (I/R) injury, but the underlying mechanism remains incompletely understood. We have previously delineated a novel mechanism of how 17β-estradiol
Kim, Jin Kyung, Liu, Han, Luo, Tao
core +1 more source