Results 21 to 30 of about 2,419,748 (303)

Extensive diet-induced atherosclerosis in scavenger receptor class B type 1-deficient mice is associated with substantial leukocytosis and elevated vascular cell adhesion molecule-1 expression in coronary artery endothelium

Frontiers in Physiology, 2023
High levels of low density lipoprotein (LDL) cholesterol and low levels of high density lipoprotein (HDL) cholesterol are risk factors for cardiovascular disease. Mice that lack genes involved in the clearance of LDL from the bloodstream, such as the LDL
Mark T. Fuller, Mark T. Fuller, Omid Dadoo, Omid Dadoo, Ting Xiong, Ting Xiong, Pardh Chivukula, Pardh Chivukula, Melissa E. MacDonald, Samuel K. Lee, Samuel K. Lee, Richard C. Austin, Richard C. Austin, Suleiman A. Igdoura, Bernardo L. Trigatti, Bernardo L. Trigatti   +15 more
doaj   +1 more source

Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes. [PDF]

PLoS ONE, 2015
The genetic targeting of mouse models has given insight into complex processes. However, phenotypes of genetically targeted mice are susceptible to artifacts due to gene manipulation, which may lead to misinterpretation of the observations.
Outi Sareila, Cecilia Hagert, Pia Rantakari, Matti Poutanen, Rikard Holmdahl   +4 more
doaj   +1 more source

Knockout Corner: Knockout mice for monoamine oxidase A [PDF]

The International Journal of Neuropsychopharmacology, 1999
A line of transgenic mice was isolated in which transgene integration had caused a deletion in the gene encoding monoamine oxidase A, an enzyme that degrades serotonin and norepinephrine. This has provided an animal model of MAOA deficiency in humans, a condition characterized by borderline mental retardation and impulsive aggression.
Isabelle, Seif, Edward, De Maeyer
openaire   +2 more sources

Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice

Science Translational Medicine, 2018
Conditional loss of BACE1 in adult mouse brain results in abnormalities in the hippocampal mossy fiber pathway, which is important for learning and memory.
Ming-Hsuan Ou-Yang, J. Kurz, Toshihiro Nomura, J. Popović, T. W. Rajapaksha, Hongxin Dong, A. Contractor, D. Chetkovich, W. Tourtellotte, R. Vassar   +9 more
semanticscholar   +1 more source

Remyelination in experimentally demyelinated connexin 32 KnockOut mice Remielinização em camundongos KnockOut para conexina 32 desmielinizados experimentalmente

Arquivos de Neuro-Psiquiatria, 2009
The aim of this study was to evaluate the role of connexin 32 (Cx 32) during remyelination of the peripheral nervous system, through a local injection of either 0,1% ethidium bromide solution or saline in the sciatic nerve of Cx 32 knockout mice ...
Adriano Tony Ramos, Paulo César Maiorka, Maria Lúcia Zaidan Dagli, Fernando Yutaka Moniwa Hosomi, Kalan Bastos Violin, Andréa Latorre, Aline de Marco Viott, Eduardo Kenji Masuda, Maria Elisa Trost, Tessie Beck Martins, Dominguita Lühers Graça   +10 more
doaj   +1 more source

One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs

Cell Research, 2017
The CRISPR/Cas9 system is an efficient gene-editing method, but the majority of gene-edited animals showed mosaicism, with editing occurring only in a portion of cells.
Erwei Zuo, Yijun Cai, Kui Li, Yu Wei, Bang-An Wang, Yidi Sun, Zhen Liu, Ji-wei Liu, Xinde Hu, Wei Wei, Xiaona Huo, Linyu Shi, Cheng Tang, Dan Liang, Yan Wang, Yanhong Nie, Chenchen Zhang, Xuan Yao, Xing Wang, Changyang Zhou, Wenqin Ying, Qifang Wang, Ren-Chao Chen, Q. Shen, Guo-Liang Xu, Jinsong Li, Qiang Sun, Z. Xiong, Hui Yang   +28 more
semanticscholar   +1 more source

Functional Genomics for the Identification of Modulators of Platelet-Dependent Thrombus Formation

TH Open, 2018
Despite the absence of the genome in platelets, transcription profiling provides important insights into platelet function and can help clarify abnormalities in platelet disorders.
Elien Vermeersch, Benedicte P. Nuyttens, Claudia Tersteeg, Katleen Broos, Simon F. De Meyer, Karen Vanhoorelbeke, Hans Deckmyn   +6 more
doaj   +1 more source

Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways. [PDF]

PLoS ONE, 2015
The renin-angiotensin system (RAS) plays a central role in blood pressure regulation. Although clinical and experimental studies have suggested that inhibition of RAS is associated with progression of anemia, little evidence is available to support this ...
Hideki Kato, Junji Ishida, Taiji Matsusaka, Tomohiro Ishimaru, Keiji Tanimoto, Fumihiro Sugiyama, Ken-Ichi Yagami, Masaomi Nangaku, Akiyoshi Fukamizu   +8 more
doaj   +1 more source

Knockout or Knock-in? A Truncated D2 Receptor Protein Is Expressed in the Brain of Functional D2 Receptor Knockout Mice

NeuroSci, 2021
Null mice for the dopamine D2 receptor (D2R) have been instrumental in understanding the function of this protein. For our research, we obtained the functional D2R knockout mouse strain described initially in 1997.
Natalia Sánchez, Montserrat Olivares-Costa, Marcela P González, Roberto Munita, Angélica P Escobar, Rodrigo Meza, Mauricio Herrera-Rojas, Jessica Albornoz, Gianluca Merello, María E Andrés   +9 more
doaj   +1 more source

Significance of Matrix Metalloproteinase-9 Inhibition by Imidapril for Prevention of Abdominal Aortic Aneurysms in Angiotensin II Type 1 Receptor–Knockout Mice

Journal of Pharmacological Sciences, 2013
To clarify the matrix metalloproteinase (MMP)-9 inhibitory effect of an angiotensin-converting enzyme (ACE) inhibitor in vivo, we evaluated the effect of an ACE inhibitor against elastase-induced abdominal aortic aneurysm (AAA) progression in mice ...
Shinji Takai, Denan Jin, Daisuke Yamamoto, Zhong-Lian Li, Yoshinori Otsuki, Mizuo Miyazaki   +5 more
doaj   +1 more source