Results 21 to 30 of about 509,570 (259)
Analysis of microRNA knockouts in mice [PDF]
Human Molecular Genetics, 2010 MicroRNAs (miRNAs) are small noncoding RNAs that act as potent regulators of gene expression. The discovery of miRNAs with specific temporal and spatial expression patterns revealed a hidden layer of post-transcriptional gene regulation. Furthermore, differential expression of miRNAs during disease progression identified miRNAs as relevant candidate ...
Chong Y, Park +2 more
openaire +2 more sources
The effect of lubricin on the gliding resistance of mouse intrasynovial tendon.
PLoS ONE, 2013 The purpose of this study was to investigate the role of lubricin on the gliding resistance of intrasynovial tendons by comparing lubricin knockout, heterozygous, and wild type mice.
Masanori Hayashi +6 more
doaj +1 more source
Integrins in vascular development
Brazilian Journal of Medical and Biological Research, 1999 Many growth factors and their protein kinase receptors play a role in regulating vascular development. In addition, cell adhesion molecules, such as integrins and their ligands in the extracellular matrix, play important roles in the adhesion, migration,
R.O. Hynes +2 more
doaj +1 more source
Neural Plasticity, 2023 Several microRNAs (miRNAs), including miR-23 and miR-27a have been reportedly involved in regulating myelination in the central nervous system. Although miR-23 and miR-27a form clusters in vivo and the clustered miRNAs are known to perform complementary ...
Yuji Tsuchikawa +8 more
doaj +1 more source
Cdk2 Knockout Mice Are Viable [PDF]
Current Biology, 2003 Cyclin-dependent kinases (Cdks) and their cyclin regulatory subunits control cell growth and division. Cdk2/cyclin E complexes are thought to be required because they phosphorylate the retinoblastoma protein and drive cells through the G1/S transition into the S phase of the cell cycle.
Berthet, Cyril +4 more
openaire +2 more sources
Establishment and identification of a mouse model of Fscb/Cabyr double gene knockout
Di-san junyi daxue xuebao, 2020 Objective To construct a mouse model of targeted knockout of Fscb/Cabyr dual genes by using the CRISPR/Cas9 system, in order to found a basis for the study of the role of FSCB and CABYR protein complexe in sperm flagellum movement and capacitation ...
LI Zhongtai +3 more
doaj +1 more source
Rab11a is required for apical protein localisation in the intestine
Biology Open, 2014 The small GTPase Rab11 plays an important role in the recycling of proteins to the plasma membrane as well as in polarised transport in epithelial cells and neurons. We generated conditional knockout mice deficient in Rab11a.
Tomoaki Sobajima +10 more
doaj +1 more source
Ovol2, a zinc finger transcription factor, is dispensable for spermatogenesis in mice
Reproductive Biology and Endocrinology, 2019 Ovol2, a mouse homolog of Drosophila ovo, was identified as a zinc finger transcription factor predominantly expressed in testis. However, the function of Ovol2 in postnatal male germ cell development remains enigmatic. Here, we firstly examined the mRNA
Jin Zhang +6 more
doaj +1 more source
Biology, 2022 AM knockout (AM-/-) and RAMP2 knockout (RAMP2-/-) proved lethal for mice due to impaired embryonic vascular development. Although most vascular endothelial cell-specific RAMP2 knockout (E-RAMP2-/-) mice also died during the perinatal period, a few E ...
Takayuki Shindo +5 more
doaj +1 more source
The roles of P2Y2 purinergic receptors in osteoblasts and mechanotransduction. [PDF]
PLoS ONE, 2014 We previously demonstrated, using osteoblastic MC3T3-E1 cells, that P2Y2 purinergic receptors are involved in osteoblast mechanotransduction. In this study, our objective was to further investigate, using a knockout mouse model, the roles of P2Y2 ...
Yanghui Xing +5 more
doaj +1 more source