Results 1 to 10 of about 2,419,748 (303)

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

, 1996
M. Oshima, J. Dinchuk, S. Kargman, H. Oshima, Bruno C. Hancock, E. Kwong, J. Trzăskos, Jilly F. Evans, M. Taketo   +8 more
semanticscholar   +1 more source

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

Proceedings of the National Academy of Sciences of the United States of America, 2003
J. Horton, Nila A. Shah, J. Warrington, Norma N. Anderson, Sahng-Wook Park, Michael S. Brown, J. Goldstein   +6 more
semanticscholar   +1 more source

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

Journal of Clinical Investigation, 1993
S. Ishibashi, Michael S. Brown, J. Goldstein, R. Gerard, R. Hammer, J. Herz   +5 more
semanticscholar   +1 more source

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

Proceedings of the National Academy of Sciences of the United States of America, 2001
G. Nicolas, M. Bennoun, I. Devaux, C. Beaumont, B. Grandchamp, A. Kahn, S. Vaulont   +6 more
semanticscholar   +1 more source

NMN improves cardiac function in SIRT3 knockout mice via the SIRT1/PGC-1α pathway

Scientific Reports
SIRT3 knockout mice develop cardiac insufficiency due to decreased mitochondrial function. However, upregulation of the NAD+/NADH ratio can compensate for SIRT3 deficiency through the SIRT1/PGC-1α pathway, thereby improving mitochondrial function.
Xiyao Zhao, Mengrui He, Lina He, Ruijie Han, Yanan Liu   +4 more
doaj   +1 more source

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.

Cell, 1999
Marion Trommsdorff, M. Gotthardt, T. Hiesberger, J. Shelton, W. Stockinger, J. Nimpf, R. Hammer, J. Richardson, J. Herz   +8 more
semanticscholar   +1 more source

Loss of Dec1 inhibits alcohol-induced hepatic lipid accumulation and circadian rhythm disorder

BMC Molecular and Cell Biology
Chronic alcohol exposure increases liver damage such as lipid accumulation and hepatitis, resulting in hepatic cirrhosis. Chronic alcohol intake is known to disturb circadian rhythms in humans and animals.
Fuyuki Sato, Ujjal K. Bhawal, Kosuke Oikawa, Yasuteru Muragaki   +3 more
doaj   +1 more source

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.

Journal of Clinical Investigation, 1997
L. Boring, J. Gosling, S. Chensue, S. Kunkel, Robert V Farese, H. Broxmeyer, I. Charo   +6 more
semanticscholar   +1 more source

From Knockout Mice to Knockout Rats [PDF]

Neurosurgery, 2003
openaire   +1 more source

Increased adipose tissue in male and female estrogen receptor-α knockout mice

, 2000
P. Heine, Julia A. Taylor, G. Iwamoto, D. Lubahn, P. Cooke   +4 more
semanticscholar   +1 more source