Results 11 to 20 of about 2,419,748 (303)
Cryptic redundancy between PAR1b and PAR1a, two members of the PAR1 kinase family, in the survival of PAR1b-knockout mice [PDF]
Scientific ReportsThe PAR1/MARK family of serine/threonine kinases (PAR1a-d) redundantly controls the cell polarity. PAR1b also mediates the phosphorylation of BRCA1, which promotes its nuclear translocation.
Naoko Murata-Kamiya +3 more
doaj +2 more sources
Approaches for timeline reductions in pathogenesis studies using genetically modified mice
Microbiology Spectrum, 2023 Although genetically modified mouse models have long been a powerful tool for microbiology research, the manipulation of the mouse genome is expensive, time consuming, and has historically remained the domain of dedicated animal facilities.
Samantha Skavicus, Nicholas S. Heaton
doaj +1 more source
Targeted disruption of the mouse testis-enriched gene Znf230 does not affect spermatogenesis or fertility [PDF]
Genetics and Molecular Biology, 2014 The mouse testis-enriched Znf230 gene, which encodes a type of RING finger protein, is present primarily in the nuclei of spermatogonia, the acrosome and the tail of spermatozoa.
Yunqiang Liu +5 more
doaj +3 more sources
Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice. [PDF]
PLoS ONE, 2013 The p21-activated kinases are effector proteins for Rho-family GTPases. PAK4, PAK5, and PAK6 are the group II PAKs associated with neurite outgrowth, filopodia formation, and cell survival.
Melody A Furnari +4 more
doaj +1 more source
Sleep in Kcna2 knockout mice [PDF]
BMC Biology, 2007 Abstract Background Shaker codes for a Drosophila voltage-dependent potassium channel. Flies carrying Shaker null or hypomorphic mutations sleep 3–4 h/day instead of 8–14 h/day as their wild-type siblings do. Shaker-like channels are conserved across species but it is unknown whether they affect sleep
Douglas, CL +6 more
openaire +6 more sources
Rapid Way to Generate Mouse Models for In Vivo Studies of the Endothelium
Journal of Lipid and Atherosclerosis, 2021 A single layer of squamous endothelial cells (ECs), the endothelium, regulates the flow of substance and fluid into and out of a tissue. The endothelium is also involved in vasculogenesis, the formation of new blood vessels, which is a crucial process ...
Ho Lee
doaj +1 more source
Frontiers in Microbiology, 2020 Altered composition of the gut microbiota has been observed in many neurodegenerative diseases. LanCL1 has been proven to protect neurons and reduce oxidative stress.
Fangxing Zhang +30 more
doaj +1 more source
Altered reward circuitry in the norepinephrine transporter knockout mouse. [PDF]
PLoS ONE, 2013 Synaptic levels of the monoamine neurotransmitters dopamine, serotonin, and norepinephrine are modulated by their respective plasma membrane transporters, albeit with a few exceptions.
Joseph J Gallagher +5 more
doaj +1 more source