Results 11 to 20 of about 1,667,987 (261)

Investigation into the role of annexin 1 in the microcirculation of annexin 1 knockout mice [PDF]

, 2005
PhDGlucocorticoids are used therapeutically for their anti-inflammatory and immunosuppressive actions. One of the ways they produce their potent effects is via regulation of the anti-inflammatory protein Annexin I (ANX-AI; 37 kDa protein).
Chatterjee, Bristi Emma
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Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. [PDF]

, 2002
As a resident of early endosomal phagosomes, Mycobacterium tuberculosis is connected to the iron uptake system of the host macrophage. beta-2-microglobulin (beta2m) knockout (KO) mice are more susceptible to tuberculosis than wild-type mice, which is ...
Friedrich Priem, Priem, F, Kaufmann, Stefan HE, Collins, Helen L, Ulrich E. Schaible, Kaufmann, S H E, Schaible, Ulrich E, Helen L. Collins, Collins, H L, Priem, Friedrich, Stefan H.E. Kaufmann, Schaible, U E   +11 more
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Mu-opioid receptor knockout mice show diminished food-anticipatory activity [PDF]

, 2004
We have previously suggested that during or prior to activation of anticipatory behaviour to a coming reward, mu-opioid receptors are activated. To test this hypothesis schedule induced food-anticipatory activity in mu-opioid receptor knockout mice was ...
van den Bos, Ruud, Schuller, Alwin G, Sub Neurobiologie van gedrag, Kas, Martien J H, Spruijt, Berry M, Sub Animal Ecology, Bedrijfsvoering, Lesscher, Heidi M B, Lubbers, Marianne, Hillebrand, Jacquelien J G, Pintar, John E, Baars, Annemarie M   +11 more
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The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system [PDF]

, 2008
INTRODUCTION: Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation. The cannabinoid receptor type 1 (CB1)
Judith Harvey-White, Francesca Lolli, Farkas, I., Amin, F., Mirjam Christ-Crain, Kola, Blerina, Fekete, Csaba, George Kunos, Kola, B., Faisal Amin, A. B. Grossman, M. Korbonits, Blerina Kola, Liposits, Zsolt, G. Kunos, Ashley B Grossman, B. Kola, Amin, F, Gábor Wittmann, Kunos, George, Christ-Crain, M, Farkas, Imre, Lolli, F, Zsolt Liposits, Lolli, F., F. Amin, Farkas, I, Christ-Crain, M., Korbonits, M., I. Farkas, Grossman, AB, C. Fekete, Kola, B, Harvey-White, J., Wittmann, Gábor, Korbonits, Márta, G. Wittmann, Harvey-White, J, Fekete, C, Harvey-White, Judith, Márta Korbonits, Imre Farkas, Liposits, Z, Z. Liposits, Grossman, Ashley B., Ashley B. Grossman, Wittmann, G., Christ-Crain, Mirjam, Amin, Faisal, Lolli, Francesca, Liposits, Z., M. Christ Crain, J. Harvey White, Fekete, C., Korbonits, M, Kunos, G., Csaba Fekete, Grossman, A. B., Kunos, G, Wittmann, G   +59 more
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Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice. [PDF]

, 2010
In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan.
Soppo, Charlotte Blanche Ekalle, Martin Klingenspor, Eugenio Scanziani, Hrabě de Angelis, M., Fabrizio Bianchi, Di Fiore, Pier Paolo, B. Pozzi, Offenhäuser Nina, Martin Hrabé de Angelis, Klingenspor Martin, B. Rathkolb, Horsch Marion, Horsch, Marion, Rathkolb, B., Nicole Ehrhardt, Wolf Eckhard, V. Gailus Durner, Tacchetti Carlo, Beckers, Johannes, Jan Rozman, Gailus-Durner, Valérie, Ralf Elvert, Hrabé de Angelis, Martin, Wolf, E., Ehrhardt, Nicole, Johannes Beckers, Elvert, Ralf, Tocchetti, Arianna, Pier Paolo Di Fiore, F. Bianchi, Elvert, R., A. Tocchetti, Horsch, M., Klingenspor, Martin, Bianchi, F., Moerth Corinna, Carlo Tacchetti, Ehrhardt Nicole, Pozzi, Benedetta, Scanziani Eugenio, Gagliani, M.C., Offenhäuser, N., Bianchi Fabrizio, Giorgio Scita, Birgit Rathkolb, M. C. Gagliani, Ehrhardt, N., Scita, G., Fuchs, Helmut, di Fiore, P.P., J. Beckers, Zani Fabio, Corinna Moerth, Eckhard Wolf, de Angelis Martin Hrabé, Mörth, C., Pozzi, B., Fuchs Helmut, M. Klingenspor, Beckers Johannes, M. Horsch, Tacchetti, C., Nina Offenhäuser, Rathkolb, Birgit, G. Scita, Tacchetti, Carlo, Bianchi, Fabrizio, Rozman, J., Rozman, Jan, Maria Cristina Gagliani, Charlotte Blanche Ekalle Soppo, Arianna Tocchetti, Ekalle Soppo Charlotte Blanche, Zani, F., N. Ehrhardt, Fuchs, H., J. Rozman, P.P. Di Fiore, Soppo, C.B.E., Valérie Gailus-Durner, Gailus-Durner, V., Gagliani, Maria Cristina, Moerth, Corinna, E. Scanziani, Scanziani, Eugenio, Helmut Fuchs, N. Offenhäuser, C. Tacchetti, Offenhäuser, Nina, Scita, Giorgio, Fabio Zani, C. Moerth, E. Wolf, Tocchetti, A., Elvert Ralf, Di Fiore Pier Paolo, M. Hrabé de Angelis, Tocchetti Arianna, Beckers, J., F. Zani, C. B. Soppo, Gagliani Maria Cristina, Scita Giorgio, Zani, Fabio, Scanziani, E., Klingenspor, M., Rathkolb Birgit, R. Elvert, Marion Horsch, Benedetta Pozzi, Pozzi Benedetta, Gailus-Durner Valérie, Wolf, Eckhard, Rozman Jan, H. Fuchs   +114 more
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Functional Genomics for the Identification of Modulators of Platelet-Dependent Thrombus Formation

TH Open, 2018
Despite the absence of the genome in platelets, transcription profiling provides important insights into platelet function and can help clarify abnormalities in platelet disorders.
Elien Vermeersch, Benedicte P. Nuyttens, Claudia Tersteeg, Katleen Broos, Simon F. De Meyer, Karen Vanhoorelbeke, Hans Deckmyn   +6 more
doaj   +1 more source

Prolactin delays hair regrowth in mice [PDF]

, 2006
Mammalian hair growth is cyclic, with hair-producing follicles alternating between active (anagen) and quiescent (telogen) phases. The timing of hair cycles is advanced in prolactin receptor (PRLR) knockout mice, suggesting that prolactin has a role in ...
Ashby, M.G., Nixon, A.J., Pearson, A.J., Ormandy, C.J., Blazek, K., Wilkins, Richard J., Craven, A.J.   +6 more
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Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways. [PDF]

PLoS ONE, 2015
The renin-angiotensin system (RAS) plays a central role in blood pressure regulation. Although clinical and experimental studies have suggested that inhibition of RAS is associated with progression of anemia, little evidence is available to support this ...
Hideki Kato, Junji Ishida, Taiji Matsusaka, Tomohiro Ishimaru, Keiji Tanimoto, Fumihiro Sugiyama, Ken-Ichi Yagami, Masaomi Nangaku, Akiyoshi Fukamizu   +8 more
doaj   +1 more source

eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice. [PDF]

, 2012
All three nitric oxide synthase (NOS) isoforms are expressed in atherosclerotic plaques. NOS enzymes in general catalyse NO production. However, under conditions of substrate and cofactor deficiency, the enzyme directly catalyse superoxide formation ...
Sabine Grüner, Ostermeier Eva, Ostermeier, Eva, Bernhard Nieswandt, Huang Paul L., Angelika Schröttle, Georg Ertl, Ertl, Georg, Ulrich Hoffmann, Peter J Kuhlencordt, Kuhlencordt Peter J., Huang, Paul, Nieswandt Bernhard, Schröttle Angelika, Grüner, Sabine, Huang, Paul L., Paul L Huang, Ponnuswamy, Padmapriya, Schröttle, Angelika, Ertl Georg, Hoffmann Ulrich, Hoffmann, Ulrich, Padmapriya Ponnuswamy, Nieswandt, Bernhard, Grüner Sabine, Ponnuswamy Padmapriya, Kuhlencordt, Peter J., Eva Ostermeier   +27 more
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Knockout or Knock-in? A Truncated D2 Receptor Protein Is Expressed in the Brain of Functional D2 Receptor Knockout Mice

NeuroSci, 2021
Null mice for the dopamine D2 receptor (D2R) have been instrumental in understanding the function of this protein. For our research, we obtained the functional D2R knockout mouse strain described initially in 1997.
Natalia Sánchez, Montserrat Olivares-Costa, Marcela P González, Roberto Munita, Angélica P Escobar, Rodrigo Meza, Mauricio Herrera-Rojas, Jessica Albornoz, Gianluca Merello, María E Andrés   +9 more
doaj   +1 more source