Results 41 to 50 of about 1,667,987 (261)

The NADPH Oxidase Isoform 1 Contributes to Angiotensin II-Mediated DNA Damage in the Kidney

Antioxidants, 2020
In higher concentrations, the blood pressure regulating hormone angiotensin II leads to vasoconstriction, hypertension, and oxidative stress by activating NADPH oxidases which are a major enzymatic source of reactive oxygen species (ROS).
Anna Zimnol, Nora Spicker, Ronja Balhorn, Katrin Schröder, Nicole Schupp   +4 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Transforming growth factor-ß (TGF-ß) signaling in hematopoiesis and tumorigenesis [PDF]

, 2008
Transforming growth factor β (TGF-β) signaling regulates numerous cellular and physiological processes. Dysfunction of components of this signaling pathway leads to a wide range of diseases ranging from malignant hematopoiesis, cardiovascular disease,
Pan, Dejing
core   +1 more source

Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging‐Related Muscle Weakness in Male Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background The activation of AT2 (angiotensin II type 2 receptor ) and Mas receptor by angiotensin II and angiotensin‐(1‐7), respectively, is the primary process that counteracts activation of the canonical renin‐angiotensin system (RAS).
Hikari Takeshita, Koichi Yamamoto, Masaki Mogi, Yu Wang, Yoichi Nozato, Taku Fujimoto, Serina Yokoyama, Kazuhiro Hongyo, Futoshi Nakagami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Masatsugu Horiuchi, Hiromi Rakugi   +14 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice. [PDF]

PLoS ONE, 2012
Evidence suggests that selenium has cancer preventive properties that are largely mediated through selenoproteins. Our previous observations demonstrated that targeted down-regulation of the 15 kDa selenoprotein (Sep15) in murine colon cancer cells ...
Petra A Tsuji, Bradley A Carlson, Salvador Naranjo-Suarez, Min-Hyuk Yoo, Xue-Ming Xu, Dmitri E Fomenko, Vadim N Gladyshev, Dolph L Hatfield, Cindy D Davis   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Slow in Motion but Smart in Learning and Memory: Behavioral Changes in Adult NR3A Knockout Mice [PDF]

, 2011
The expression of NMDA receptor subunit NR3A is high in the neonatal brain but low in adults. However, its functional role in the adult brain is obscure.
Shan Ping Yu, Ling Wei, Osama Mohamad, Mingke Song   +3 more
core  

Noninvasive, In Vivo Assessment of Mouse Retinal Structure Using Optical Coherence Tomography [PDF]

, 2009
BACKGROUND: Optical coherence tomography (OCT) is a novel method of retinal in vivo imaging. In this study, we assessed the potential of OCT to yield histology-analogue sections in mouse models of retinal degeneration.
Gesine Huber, Huber, G., Muehlfriedel, Regine, Edda Fahl, Jan Wijnholds, Beck, SC, Remé Charlotte E., Tanimoto, Naoyuki, Tanimoto Naoyuki, Pacal, M, Van de Pavert, S.A., Fischer M. Dominik, Fischer, M.D., Pacal Marek, Christian Grimm, Muehlfriedel Regine, Wenzel, Andreas, Charlotte E Remé, Charlotte E. Remé, Pacal, Marek, Serge A van de Pavert, M. Dominik Fischer, Rod Bremner, Wenzel, A., Bremner Rod, Remé, Charlotte E, Fischer, M Dominik, Susanne C. Beck, Huber, Gesine, Wijnholds, J, Fahl, E, Beck, S.C., Marek Pacal, Grimm Christian, Wenzel, A, Regine Muehlfriedel, Huber Gesine, Wijnholds, Jan, Tanimoto, N, Bremner, R., Reme, C.E., Wijnholds, Jan; https://orcid.org/, Bremner, R, Seeliger Mathias W., Beck, Susanne C., Fischer, M. Dominik, Mathias W Seeliger, Wijnholds Jan, Bremner, Rod, van de Pavert Serge A., M Dominik Fischer, Andreas Wenzel, Mühlfriedel, Regine, Tanimoto, N., Fahl, E., Seeliger, Mathias W, Fischer, Manuel, Beck Susanne C., Seeliger, Mathias W., Remé, Charlotte E., Van De Pavert, SA, Fahl, Edda, Pacal, M., Remé, CE, van de Pavert, Serge A., Beck, Susanne C; https://orcid.org/, Huber, G, Grimm, C., Seeliger, MW, Wenzel Andreas, Fahl Edda, Mathias W. Seeliger, Pavert, S.A. van de, Grimm, C, Grimm, Christian, Grimm, Christian; https://orcid.org/, Muehlfriedel, R., Serge A. Van De Pavert¤b, Wijnholds, J., van de Pavert, Serge A, Susanne C Beck, Fischer, MD, Muehlfriedel, R, Seeliger, M.W., Naoyuki Tanimoto   +84 more
core   +2 more sources

Heterozygous Mylk3 Knockout Mice Partially Recapitulate Human DCM With Heterozygous MYLK3 Mutations

Frontiers in Physiology, 2019
Backgrounds: Recent studies identified heterozygous variants in MYLK3 gene that encodes cardiac myosin light chain kinase (cMLCK) are related to familial dilated cardiomyopathy (DCM) for the first time. Autosomal dominant traits suggest that pathogenesis
Carson L. Tougas, Tabor Grindrod, Lawrence X. Cai, Fariz F. Alkassis, Hideko Kasahara   +4 more
doaj   +1 more source