Results 41 to 50 of about 2,419,748 (303)

Establishment and identification of a mouse model of Fscb/Cabyr double gene knockout

Di-san junyi daxue xuebao, 2020
Objective To construct a mouse model of targeted knockout of Fscb/Cabyr dual genes by using the CRISPR/Cas9 system, in order to found a basis for the study of the role of FSCB and CABYR protein complexe in sperm flagellum movement and capacitation ...
LI Zhongtai, LI Zhongtai, LI Yanfeng, LIU Jinyi   +3 more
doaj   +1 more source

Dental and periodontal phenotype in sclerostin knockout mice

International Journal of Oral Science, 2014
Sclerostin is a Wnt signalling antagonist that controls bone metabolism. Sclerostin is expressed by osteocytes and cementocytes; however, its role in the formation of dental structures remains unclear.
U. Kuchler, U. Schwarze, T. Dobsak, P. Heimel, D. Bosshardt, M. Kneissel, R. Gruber   +6 more
semanticscholar   +1 more source

The roles of P2Y2 purinergic receptors in osteoblasts and mechanotransduction. [PDF]

PLoS ONE, 2014
We previously demonstrated, using osteoblastic MC3T3-E1 cells, that P2Y2 purinergic receptors are involved in osteoblast mechanotransduction. In this study, our objective was to further investigate, using a knockout mouse model, the roles of P2Y2 ...
Yanghui Xing, Yan Gu, James J Bresnahan, Emmanuel M Paul, Henry J Donahue, Jun You   +5 more
doaj   +1 more source

Receptor Activity Modifying Protein RAMP Sub-Isoforms and Their Functional Differentiation, Which Regulates Functional Diversity of Adrenomedullin

Biology, 2022
AM knockout (AM-/-) and RAMP2 knockout (RAMP2-/-) proved lethal for mice due to impaired embryonic vascular development. Although most vascular endothelial cell-specific RAMP2 knockout (E-RAMP2-/-) mice also died during the perinatal period, a few E ...
Takayuki Shindo, Megumu Tanaka, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Takayuki Sakurai   +5 more
doaj   +1 more source

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

Cell Research, 2013
Mixed lineage kinase domain-like protein (Mlkl) was recently found to interact with receptor interacting protein 3 (Rip3) and to be essential for tumor necrosis factor (TNF)-induced programmed necrosis (necroptosis) in cultured cell lines.
Jianfeng Wu, Zhe Huang, Junming Ren, Zhirong Zhang, Peng He, Yangxin Li, Jianhui Ma, Wanze Chen, Yingying Zhang, Xiaojuan Zhou, Zhentao Yang, Su-qin Wu, Lanfen Chen, Jiahuai Han   +13 more
semanticscholar   +1 more source

Ovol2, a zinc finger transcription factor, is dispensable for spermatogenesis in mice

Reproductive Biology and Endocrinology, 2019
Ovol2, a mouse homolog of Drosophila ovo, was identified as a zinc finger transcription factor predominantly expressed in testis. However, the function of Ovol2 in postnatal male germ cell development remains enigmatic. Here, we firstly examined the mRNA
Jin Zhang, Juan Dong, Weibing Qin, Congcong Cao, Yujiao Wen, Yunge Tang, Shuiqiao Yuan   +6 more
doaj   +1 more source

Generation and Characterization of Rac3 Knockout Mice [PDF]

Molecular and Cellular Biology, 2005
Rac proteins are members of the Rho family of GTPases involved in the regulation of actin dynamics. The three highly homologous Rac proteins in mammals are the ubiquitous Rac1, the hematopoiesis-specific Rac2, and the least-characterized Rac3. We show here that Rac3 mRNA is widely and specifically expressed in the developing nervous system, with ...
Corbetta S, Gualdoni S, Albertinazzi C, Paris S, Croci L, CONSALEZ , GIAN GIACOMO, DE CURTIS , IVANMATTEO   +6 more
openaire   +3 more sources

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Nature Cell Biology, 2014
Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour types, and in engineered cells overexpressing oncogenic RAS. Yet, its relevance in non-transformed cells and tissues is unexplored and remains enigmatic. Here,
J. Angeli, Manuela Schneider, B. Proneth, Y. Tyurina, V. Tyurin, V. Hammond, N. Herbach, M. Aichler, A. Walch, E. Eggenhofer, Devaraj Basavarajappa, O. Rådmark, Sho Kobayashi, Tobias Seibt, H. Beck, F. Neff, I. Esposito, R. Wanke, H. Förster, O. Yefremova, Marc Heinrichmeyer, G. Bornkamm, E. Geissler, Stephen B. Thomas, B. Stockwell, V. O’Donnell, V. Kagan, Joel A. Schick, M. Conrad   +28 more
semanticscholar   +1 more source

Pdgfrα-Cre mediated knockout of the aryl hydrocarbon receptor protects mice from high-fat diet induced obesity and hepatic steatosis.

PLoS ONE, 2020
Aryl hydrocarbon receptor (AHR) agonists such as dioxin have been associated with obesity and the development of diabetes. Whole-body Ahr knockout mice on high-fat diet (HFD) have been shown to resist obesity and hepatic steatosis.
Francoise A Gourronc, Kathleen R Markan, Katarina Kulhankova, Zhiyong Zhu, Ryan Sheehy, Dawn E Quelle, Leonid V Zingman, Zoya B Kurago, James A Ankrum, Aloysius J Klingelhutz   +9 more
doaj   +1 more source

Selenoprotein F Knockout Caused Glucose Metabolism Disorder in Young Mice by Disrupting Redox Homeostasis

Antioxidants, 2022
Selenoprotein F (SELENOF) might play an important role in maintaining human health since an increasing number of studies have linked SELENOF deficiency to various pathologies such as cancer and neurodegeneration.
Min Li, Yun Zhang, Jun Zhou, Hongmei Liu
doaj   +1 more source