Results 91 to 100 of about 9,552,944 (333)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A short survey of discourse representation models [PDF]

, 2009
With the advancement of technology and the wide adoption of ontologies as knowledge representation formats, in the last decade, a handful of models were proposed for the externalization of the rhetoric and argumentation captured within scientific ...
Buckingham Shum, S., Clark, T., de Waard, A., Groza, T., Handschuh, S.   +4 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Representation and matching of knowledge to design digital systems [PDF]

, 1988
A knowledge-based expert system is described that provides an approach to solve a problem requiring an expert with considerable domain expertise and facts about available digital hardware building blocks.
Jones, J. U., Shiva, S. G.
core   +1 more source

Sci-K 2022 - International Workshop on Scientific Knowledge: Representation, Discovery, and Assessment [PDF]

, 2022
Paolo Manghi, Andrea Mannocci, Francesco Osborne, Dimitris Sacharidis, Angelo A. Salatino, Thanasis Vergoulis   +5 more
openalex   +1 more source

Democratizing knowledge representation with BioCypher

Nature Biotechnology, 2023
Sebastian Lobentanzer, P. Aloy, Jan Baumbach, B. Bohár, V. Carey, P. Charoentong, K. Danhauser, Tunca Dogan, Johann Dréo, Ian Dunham, Elias Farr, Adrià Fernández-Torras, Benjamin M. Gyori, Michael Hartung, Charles Tapley Hoyt, Christoph Klein, T. Korcsmáros, Andreas Maier, Matthias Mann, D. Ochoa, Elena Pareja-Lorente, Ferdinand Popp, M. Preusse, Niklas Probul, Benno Schwikowski, Bunyamin Sen, Maximilian T. Strauss, D. Turei, Erva Ulusoy, Dagmar Waltemath, Judith A. H. Wodke, J. Saez-Rodriguez   +31 more
semanticscholar   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Specialized Knowledge Representation and the Parameterization of Context

Frontiers in Psychology, 2016
Though instrumental in numerous disciplines, context has no universally accepted definition. In specialized knowledge resources it is timely and necessary to parameterize context with a view to more effectively facilitating knowledge representation ...
P. Faber, P. León-Araúz
semanticscholar   +1 more source

Cerebral cortex classification by conditional random fields applied to intraoperative thermal imaging

Current Directions in Biomedical Engineering, 2016
Intraoperative thermal neuroimaging is a novel intraoperative imaging technique for the characterization of perfusion disorders, neural activity and other pathological changes of the brain.
Hoffmann Nico, Koch Edmund, Petersohn Uwe, Kirsch Matthias, Steiner Gerald   +4 more
doaj   +1 more source