Results 91 to 100 of about 733,474 (306)

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Objetos digitais acessíveis:

Advances in Knowledge Representation
Pesquisa que investiga a representação da informação de objetos digitais acessíveis nas perspectivas descritiva e de acessibilidade em biblioteca digital.
Izadora Oliveira Linhares, Márcio Bezerra da Silva   +1 more
doaj  

From informal knowledge to formal logic: a realistic case study in medical protocols

, 2002
We report our experience in a case study with constructing fully formalised knowledge models of realistic, specialised medical knowledge. We have taken a medical protocol in daily use by medical specialists, modelled this knowledge in a specific-purpose ...
van Harmelen, Frank, Balser, Michael, Frank van Harmelen, ten Teije, Annette, Mar Marcos, Marcos, Mar, Ten Teije, Annette; id_orcid, Michael Balser, van Harmelen, Frank; id_orcid, Annette ten Teije   +9 more
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Knowledge Representation using Schema Tuple Queries

, 2003
This paper introduces schema tuple queries and argues for their suitability in representing knowledge over standard relational databases. Schema tuple queries are queries that return only whole tuples of schema relations.
Minock, Michael,
core  

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Discurso ontológico – Diferença entre dado cadastral e indício tributário no contexto de um sistema cadastral nacional e a implantação do Sinter e do CIB

Advances in Knowledge Representation
Este artigo propõe uma abordagem ontológica para diferenciar dado cadastral e indício tributário no processo de desenvolvimento de um sistema cadastral nacional. A distinção entre os conceitos fortalece a governança de dados, a justiça fiscal e a função
Fernanda de Souza Farias, Antònio Augusto Ferreira de Oliveira   +1 more
doaj  

An Extension of Frame-Based Knowledge Representation Schema

This paper presents an overview of frame–based knowledge representation and Structural Modelling approach as well as a new extension of frame–based knowledge representation schema is described.
Grundspeņķis, Jānis, Zeltmate, Ieva
core  

TYPICAL: A Knowledge Representation System for Automated Discovery and Inference

, 1987
TYPICAL is a package for describing and making automatic inferences about a broad class of SCHEME predicate functions. These functions, called types following popular usage, delineate classes of primitive SCHEME objects, composite data structures ...
Haase, Kenneth W., Jr.
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source