Results 91 to 100 of about 9,109,199 (294)
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Categories in Top-Level Ontologies: Revisiting the Aristotelian Background
Advances in Knowledge Representation. In the field of applied ontology, it is now commonplace to refer to a top-level ontology, and the Basic Formal Ontology (BFO) has even been recognized as an ISO standard.
Ludger Jansen, Barry Smith
doaj
A study on object-oriented knowledge representation
, 1995 This thesis is a study on object-oriented knowledge representation. The study defines the main concepts of the object model. It also shows pragmatically the use of object-oriented methodology in the development of a concrete software system designed as ...
Salgado-Arteaga, Francisco
core
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Advances in Knowledge RepresentationPesquisa que investiga a representação da informação de objetos digitais acessíveis nas perspectivas descritiva e de acessibilidade em biblioteca digital.
Izadora Oliveira Linhares +1 more
doaj
Legal linguistic templates and the tension between legal knowledge representation and reasoning. [PDF]
Front Artif Intell, 2023 Libal T.
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source