Results 51 to 60 of about 3,293,562 (272)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Editorial

Advances in Knowledge Representation
A publicação dessa edição especial da revista AKR dedicada ao tema "Um modelo ontológico para o sistema cadastral brasileiro" reflete uma importante e necessária discussão sobre a administração territorial no país.
Suzana Daniela
doaj   +2 more sources

A short survey of discourse representation models [PDF]

, 2009
With the advancement of technology and the wide adoption of ontologies as knowledge representation formats, in the last decade, a handful of models were proposed for the externalization of the rhetoric and argumentation captured within scientific ...
Buckingham Shum, S., Clark, T., de Waard, A., Groza, T., Handschuh, S.   +4 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Knowledge-aware Complementary Product Representation Learning

, 2019
Learning product representations that reflect complementary relationship plays a central role in e-commerce recommender system. In the absence of the product relationships graph, which existing methods rely on, there is a need to detect the complementary
Koren Yehuda, Le Quoc, Papagelis Manos, Recht Benjamin, Rendle Steffen, Soboroff Ian, Wainwright Martin J   +6 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

An Intelligent Monitoring System for the Safety of Building Structure under the W2T Framework

International Journal of Distributed Sensor Networks, 2015
Monitoring systems for the safety of building structure (SBS) can provide people with important data related to main supporting points in a building and then help people to make a reasonable maintenance schedule.
Haiyuan Wang, Zhisheng Huang, Ning Zhong, Jiajin Huang, Yuzhong Han, Feng Zhang   +5 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

LEGAL KNOWLEDGE REPRESENTATION MODEL

Известия высших учебных заведений. Поволжский регион:Технические науки, 2020
Background. The need to automate the decision-making process on legal issues in various fields of human activity determines the importance of this work.
P. A. Gudkov, E. M. Podmar'kova
doaj   +1 more source

Towards OWL-based Knowledge Representation in Petrology

, 2011
This paper presents our work on development of OWL-driven systems for formal representation and reasoning about terminological knowledge and facts in petrology.
Kudryavtsev, Dmitry, Ryakhovsky, Vladimir, Shkotin, Alex   +2 more
core