Results 51 to 60 of about 733,474 (306)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

PERANCANGAN MODEL REPRESENTASI PENGETAHUAN BERBASIS ONTOLOGI PADA APLIKASI SIPELANTIK: STUDI KASUS PUSINTEK KEMENTERIAN KEUANGAN

Jurnal Sistem Informasi, 2015
In supporting the implementation of ICT service management, Pusat Sistem Informasi dan Teknologi Keuangan (Pusintek) already have the Sistem Pengelolaan Layanan Teknologi Informasi dan Komunikasi (Sipelantik) application.
Andrianto Susilo, Putu Wuri Handayani, Iik Wilarso   +2 more
doaj   +3 more sources

Representation Learning of Knowledge Graphs via Fine-Grained Relation Description Combinations

IEEE Access, 2019
Knowledge representation learning attempts to represent entities and relations of knowledge graph in a continuous low-dimensional semantic space. However, most of the existing methods such as TransE, TransH, and TransR usually only utilize triples of ...
Ming He, Xiangkun Du, Bo Wang
doaj   +1 more source

Bio-Inspired Approaches to Safety and Security in IoT-Enabled Cyber-Physical Systems

Sensors, 2020
Internet of Things (IoT) and Cyber-Physical Systems (CPS) have profoundly influenced the way individuals and enterprises interact with the world. Although attacks on IoT devices are becoming more commonplace, security metrics often focus on software ...
Anju P. Johnson, Hussain Al-Aqrabi, Richard Hill   +2 more
doaj   +1 more source

Knowledge representation with logic programs [PDF]

, 1998
In this overview we show how Knowledge Representation (KR) can be done with the help of generalized logic programs. We start by introducing the core of PROLOG, which is based on definite logic programs. Although this class is very restricted (and will be enriched by various additional features in the rest of the paper), it has a very nice property for ...
Gerhard Brewka, Jürgen Dix
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Knowledge Representation and WordNets [PDF]

Knowledge itself is a representation of “real facts”. Knowledge is a logical model that presents facts from “the real world” witch can be expressed in a formal language. Representation means the construction of a model of some part of reality. Knowledge
Alexandra Gabriela Tudorache
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Knowledge representation with T

Artificial Intelligence Research, 2018
The universal representation language T proposed in the article is the set of linguistic items employed in the manner of a natural language with the purpose of information exchange between various communicators. The language is not confined to any particular representation domain, implementation, communicator or discourse type.
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source