Results 91 to 100 of about 17,687,028 (211)

Emergence of Raoultella ornithinolytica Coproducing IMP-4 and KPC-2 Carbapenemases in China [PDF]

Antimicrobial Agents and Chemotherapy, 2015
ABSTRACT We report here the emergence of seven IMP-4-producing Raoultella ornithinolytica isolates obtained from one patient. All isolates carried the bla IMP-4 carbapenemase gene, five isolates also carried bla SHV-12 , four contained
Beiwen, Zheng, Jing, Zhang, Jinru, Ji, Yunhui, Fang, Ping, Shen, Chaoqun, Ying, Jifang, Lv, Yonghong, Xiao, Lanjuan, Li   +8 more
openaire   +2 more sources

Resolved gamma ray emission of the supernova remnant W51C and HESS J1857+026 obtained with the MAGIC telescopes [PDF]

, 2013
Diese Dissertation untersucht den Urspung der kosmischen Strahlung mit Beobachtungen der MAGIC Teleskope im Bereich der hoch energeticher Gammastrahlenastronomie. Gammastrahlung wird bei der Wechselwirkung relativistischer Teilchen erzeugt.
Krause, Julian D. G.
core  

FGFR Inhibitor AZD4547 Disrupts Inflammatory CAF Crosstalk With Cancer Cells and Macrophages and Attenuates Metastasis in Pancreatic Cancer

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
This study demonstrates that FGFR‐targeted inhibition by AZD4547 in inflammatory cancer‐associated fibroblasts (iCAFs) intervenes into the tumor–stroma crosstalk. AZD4547 blocks IL‐1α–induced differentiation of pancreatic stellate cells into iCAFs, impairing iCAF‐driven tumor cell differentiation, migration, and M2 macrophage polarization. Consequently,
Ahmed M. R. H. Mostafa, Ahmed G. Hemdan, Franck Assayag, Jai Prakash   +3 more
wiley   +1 more source

Patient Perspectives on Psychiatric Polygenic Risk Scores in Reproductive Decision‐Making and Polygenic Embryo Screening

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 5, Page 338-348, July 2026.
ABSTRACT Polygenic risk scores (PRS) estimate individuals' genetic risk for developing multifactorial conditions. Recent genome‐wide association studies have enabled development of psychiatric PRS, which hold potential to streamline diagnosis and treatment of psychiatric conditions.
Lauren A. Ginn, Amanda R. Merner, Page M. Trotter, Kaitlynn P. Craig, Abigail C. Martinez, Ana Lucía Battaglino, Dorit Barlevy, Daphne M. Ayton, Takahiro Soda, Eric A. Storch, Gabriel Lázaro‐Muñoz, Stacey Pereira   +11 more
wiley   +1 more source

Global phylogeography and genetic characterization of carbapenem and ceftazidime-avibactam resistant KPC-33-producing Pseudomonas aeruginosa

npj Antimicrobials and Resistance
Ceftazidime-avibactam (CZA) is currently one of the last resorts used to treat infections caused by carbapenem-resistant Enterobacteriaceae and Pseudomonas aeruginosa.
Longjie Zhou, Jiayao Yao, Ying Zhang, Xiaofan Zhang, Yueyue Hu, Haiyang Liu, Jintao He, Yunsong Yu, Minhua Chen, Yuexing Tu, Xi Li   +10 more
doaj   +1 more source

Identification of a Novel KPC Variant, KPC-204, Conferring Resistance to Both Carbapenems and Ceftazidime–Avibactam in an ST11 Klebsiella pneumoniae Strain

Microorganisms
This study describes KPC-204, a novel variant of Klebsiella pneumoniae carbapenemase, characterized by a Lys-Asp-Asp (KDD) amino acid insertion at Ambler position 269 deviates from KPC-2.
Yanqiao Gong, Yu Feng, Xiaoju Lv
doaj   +1 more source

Modified Sleep Apnea Severity Index and Cardiovascular Risk in CPAP‐Intolerant OSA Patients

The Laryngoscope, Volume 136, Issue 7, Page 3262-3270, July 2026.
The modified sleep apnea severity index (mSASI) combines patient anatomy, weight, sleep study metrics, and symptoms into a composite OSA index ranging from 1 (least severe) to 3 (most severe). Our study found that mSASI correlated better with baseline cardiovascular risk measured by the 5‐year Framingham Risk Score compared to the AHI.
Praneet C. Kaki, Jennifer A. Goldfarb, Melissa Xu, Daniel J. Campbell, Nicole Molin, Erin Creighton, Thomas M. Kaffenberger, Maurits Boon, Colin Huntley   +8 more
wiley   +1 more source

Structural basis of ligand selectivity in FAD/NAD(P)H‐dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase

Protein Science, Volume 35, Issue 7, July 2026.
Abstract FAD/NAD(P)H‐dependent dehydrogenases form a structurally conserved family of redox enzymes that participate in essential metabolic processes across parasites and higher organisms. Among them, trypanothione reductase (TR) is a key component of the redox metabolism of Leishmania species and represents an attractive target for antileishmanial ...
Giulia Chiara Maria Perrone, Serena Spadone, Anna Lucia Francavilla, Sara Morselli, Sabino Todisco, Margherita Ortalli, Jairo Alfonso Mendoza‐Roldan, Valeria Scaglione, Maria Noemi Sgobba, Lorenzo Guerra, Federica Belluti, Stefania Varani, Domenico Otranto, Anna De Grassi, Mariateresa Volpicella, Ciro Leonardo Pierri   +15 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1473-1493, June 2026.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

High prevalence of KPC-2-producing hypervirulent Klebsiella pneumoniae causing meningitis in Eastern China

, 2019
Min Xu,1,* Yiqi Fu,2,* Yunhui Fang,3 Hao Xu,3 Haishen Kong,3 Yanchao Liu,1 Yu Chen,1,3 Lanjuan Li3 1Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Center of Clinical Laboratory, The First Affiliated Hospital, College of ...
Fang Y, Liu Y, Xu M, Fu Y, Chen Y, Xu H, Li L, Kong H   +7 more
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