Results 91 to 100 of about 34,694 (215)

Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation

Advanced Science, EarlyView.
Nanoplastics are pervasive environmental contaminants with potentially profound implications for human health. Emerging evidence suggests a possible link between nanoplastic exposure and neurodegeneration, a key driver of ageing and dementia, yet causality remains unresolved.
Yuhuan Li, Yue Wang, Xiufang Liang, Mengze Xu, David T. Leong, Pu Chun Ke   +5 more
wiley   +1 more source

Star Clusters in the Tidal Tails of Interacting Galaxies: Cluster Populations Across a Variety of Tail Environments

, 2011
We have searched for compact stellar structures within 17 tidal tails in 13 different interacting galaxies using F606W- and F814W- band images from the Wide Field Planetary Camera 2 (WFPC2) on the Hubble Space Telescope (HST).
A. A. Kepley, A. Maybhate, Alonso-Herrero, B. Mullan, Bastian, Beirão, Bigiel, Bigiel, Billett, Binney, Blitz, Brinks, C. Gronwall, C. Palma, Chien, D. Elmegreen, Davies, Dolphin, Duc, Duc, Elmegreen, Elmegreen, Elmegreen, Elmegreen, Erwin, Fall, G. Trancho, Gieles, Greisen, Hancock, Hancock, Helou, Hibbard, Hibbard, Hibbard, Hibbard, Hibbard, I. S. Konstantopoulos, J. C. Charlton, J. E. Hibbard, J. English, Jeske, K. E. Johnson, K. H. Lee, K. Knierman, Kennicutt, Kennicutt, Knierman, Knierman, Konstantopoulos, Kundu, Larsen, Lee, Maybhate, Maíz Apellániz, Meurer, Mirabel, N. Bastian, Neff, P. R. Durrell, Peterson, R. Chandar, Rasband, Renaud, S. C. Gallagher, S. Hunsberger, Sault, Saviane, Schaye, Schlegel, Schweizer, Smith, Toomre, Tran, Trancho, Verschuur, W. D. Vacca, Weilbacher, Wevers, Whitmore, Whitmore, Whitmore, Yoshida, Zepf   +83 more
core   +1 more source

Inhibition of Focal Adhesion Restricts Chemoresistance in Pancreatic Cancer by Targeting SLC7A11 Mediated Ferroptosis

Advanced Science, EarlyView.
FAK signaling drives chemoresistance and tumor evolution in pancreatic ductal adenocarcinoma. The FAK inhibitor IN10018 restores gemcitabine sensitivity by inducing SLC7A11‐mediated ferroptosis through the PI3K‐Akt pathway and remodeling the tumor microenvironment, reducing mesenchymal components while enhancing CD8+ T‐cell infiltration in preclinical ...
Yingjin Wang, Hui Yang, Baoyuan Zhang, Yongsu Ma, Kuangen Zhang, Peng Wang, Jiapeng Yang, Zaiqi Wang, Rong Liu, Xiaodong Tian, Ning Zhang, Yinmo Yang   +11 more
wiley   +1 more source

The Atomic to Molecular Transition and its Relation to the Scaling Properties of Galaxy Disks in the Local Universe [PDF]

, 2010
We extend existing semi-analytic models of galaxy formation to track atomic and molecular gas in disk galaxies. Simple recipes for processes such as cooling, star formation, supernova feedback, and chemical enrichment of the stars and gas are grafted on ...
Arnett, Avila-Reese, Bigiel, Blitz, Blitz, Boissier, Boselli, Bottema, Boulanger, Bower, Catinella, Chabrier, Cole, Cooper, Croton, Dalcanton, De Lucia, Dekel, Dekel, Dutton, Dutton, Elmegreen, Elmegreen, Fu, Genzel, Gnedin, Guinevere Kauffmann, Guo, Helfer, Jian Fu, Kauffmann, Kauffmann, Kauffmann, Kennicutt, Kennicutt, Kennicutt, Keres, Kereš, Krumholz, Krumholz, Laurikainen, Leroy, Li, Madau, Mark R. Krumholz, McKee, Mo, Obreschkow, Obreschkow, Qi Guo, Reynolds, Roškar, Schmidt, Schönrich, Somerville, Somerville, Springel, Sutherland, Toomre, Tremonti, Van Den Bosch, Walter, Weinzirl, White, Wong, Zwaan   +65 more
core   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

The UK Infrared Telescope M33 monitoring project. III. Feedback from dusty stellar winds in the central square kiloparsec

, 2013
We have conducted a near-infrared monitoring campaign at the UK InfraRed Telescope (UKIRT), of the Local Group spiral galaxy M33 (Triangulum). The main aim was to identify stars in the very final stage of their evolution, and for which the luminosity is ...
Javadi, Atefeh, Khosroshahi, Habib, Mirtorabi, Mohammad Taghi, van Loon, Jacco Th.   +3 more
core   +1 more source

Emergence of Carbapenemase Producing Klebsiella Pneumonia and Spread of KPC-2 and KPC-17 in Taiwan: A Nationwide Study from 2011 to 2013. [PDF]

PLoS ONE, 2015
The emergence of carbapenemase-producing Klebsiella pneumoniae (CPKP) has become a great concern worldwide. In this study, 994 non-duplicate, carbapenem non-susceptible Klebsiella pneumonia isolates were collected in Taiwan from 2011 to 2013 for ...
I-Ling Tseng, Yu-Mei Liu, Shiow-Jen Wang, Hung-Yi Yeh, Chia-Lun Hsieh, Hsueh-Lin Lu, Yu-Chuan Tseng, Jung-Jung Mu   +7 more
doaj   +1 more source

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, EarlyView.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source

Compact High-Redshift Galaxies Are the Cores of the Most Massive Present-Day Spheroids [PDF]

, 2009
Observations suggest that effective radii of high-z massive spheroids are as much as a factor ~6 smaller than low-z galaxies of comparable mass. Given the apparent absence of low-z counterparts, this has often been interpreted as indicating that the high
Abraham, Allen, Balcells, Balcells, Barden, Barnes, Bell, Bell, Bender, Bernardi, Bernardi, Bezanson, Borch, Bower, Boylan-Kolchin, Brown, Buitrago, Burkert, Cenarro, Chabrier, Chung-Pei Ma, Cimatti, Conroy, Cox, Côté, Côté, Daddi, Damjanov, di Serego Alighieri, Eliot Quataert, Faber, Faber, Ferguson, Ferrarese, Ferreras, Fontana, Franx, Gallagher, Gallazzi, Graham, Graves, Grazian, Hausman, Hernquist, Hibbard, Hopkins, Hopkins, Hopkins, Hopkins, Hopkins, Hopkins, Hopkins, Hopkins, Hopkins, Hopkins, Hopkins, Jesseit, Jones, Kennicutt, Kevin Bundy, Khochfar, Komatsu, Kormendy, Kormendy, Kriek, Kriek, Kriek, Labbé, Lauer, Lin, Maraston, Maraston, Marchesini, Masjedi, McIntosh, Mihos, Milosavljević, Naab, Naab, Naab, Nelan, Norman Murray, Ostriker, Oñorbe, Philip F. Hopkins, Pérez-González, Pérez-González, Quadri, Ravindranath, Robertson, Rothberg, Schweizer, Shapiro, Shen, Somerville, Sánchez-Blázquez, Tacconi, Tacconi, Thomas, Thompson, Tod R. Lauer, Toft, Trager, Treu, Trujillo, Trujillo, Trujillo, Trujillo, Trujillo, Trujillo, van der Wel, van der Wel, van der Wel, van Dokkum, van Dokkum, van Dokkum, van Dokkum, Weil, Weil, Wuyts, Wuyts, Yamauchi, Younger, Younger, Zheng, Zirm   +125 more
core   +3 more sources

Plasmid-Mediated Carbapenem-Hydrolyzing Enzyme KPC-2 in an Enterobacter sp [PDF]

Antimicrobial Agents and Chemotherapy, 2004
ABSTRACT A strain of an Enterobacter sp. with reduced susceptibility to imipenem, which produced a plasmid-mediated class A carbapenem-hydrolyzing enzyme, KPC-2 β-lactamase, was isolated from a patient with sepsis at a Boston hospital. This is the first report of the production of a plasmid-encoded KPC-2 β-
Ashfaque, Hossain, M J, Ferraro, R M, Pino, R B, Dew, E S, Moland, T J, Lockhart, K S, Thomson, R V, Goering, N D, Hanson   +8 more
openaire   +2 more sources