Results 101 to 110 of about 17,687,028 (211)

Diverse evolutionary trajectories of Klebsiella pneumoniae carbapenemase: unraveling the impact of amino acid substitutions on β-lactam susceptibility and the role of avibactam in driving resistance

mSystems
Klebsiella pneumoniae carbapenemases (KPCs) have evolved into over 245 distinct variants, with over one-third of variants exhibiting reduced susceptibility to ceftazidime-avibactam, while the underlying selection mechanisms remain elusive.
Jie Wei, Jinyu Huang, Chunhong Zou, Shimei Shen, Barry N. Kreiswirth, Ailong Huang, Shifeng Huang, Liang Chen, Deqiang Wang, Siqiang Niu   +9 more
doaj   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, Volume 13, Issue 35, 24 June 2026.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Isolation of a Ceftazidime-Avibactam-Resistant blaKPC-71-Positive Klebsiella pneumoniae Clinical Isolate

Microbiology Spectrum, 2022
Siquan Shen, Qingyu Shi, Renru Han, Yan Guo, Yang Yang, Shi Wu, Dandan Yin, Fupin Hu   +7 more
doaj   +1 more source

ST11 KPC-2-Producing Klebsiella pneumoniae Isolated from Patient with Acute Myelocytic Leukemia

Infection and Drug Resistance
Can Chen,1 Fan Yang,1 Mantao Chen,2 Ying Xu,1 Yaping Xie,1 Ruishan Liu,3 Pengfei Shi,1 Shenxian Qian1 1Department of Hematology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, People’s ...
Chen C, Yang F, Chen M, Xu Y, Xie Y, Liu R, Shi P, Qian S   +7 more
doaj  

Superposition of complexes of KPC-2 and SHV-1 bound with avibactam.

, 2015
Superimposed are KPC-2 (cyan carbon atoms) and SHV-1 (grey carbon atoms). The nitrogen N1 is labelled ‘1’ and ‘1’” for KPC-2 and SHV-1, respectively, to indicate the differences in the chirality and direction of the lone pair electrons that nitrogen in ...
Nikhil P. Krishnan (792291), Focco van den Akker (158508), Nhu Q. Nguyen (792292), Robert A. Bonomo (188763), Krisztina M. Papp-Wallace (792293)   +4 more
core   +1 more source

Pharmacophore hypothesis for KPC-2 ligands.

, 2018
Binding site of KPC-2 (PDB code 3RXW, blue) superimposed with a fragment of the ligand OJ6 bound to CTX-M-9 β-lactamase (PDB code 4DE1, cyan) and pharmacophore features (red: hydrogen-bond acceptor, orange: hydrophobic interaction feature, purple ...
Pasquale Linciano (4426435), Giuseppe Celenza (4632985), Jesus Blazquez (6029207), Raphael Klein (5793428), Pierangelo Bellio (4632979), Laura Cendron (222504), Sofia Papaioannou (6029204), Ruth Brenk (325207), Donatella Tondi (2467822)   +8 more
core   +1 more source

Management of KPC-Producing Klebsiella pneumoniae Infections [PDF]

, 2017
Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) has become one of the most important contemporary pathogens, especially in endemic ...
E.J. Giamarellos-Bourboulis, Giacobbe, D. R, Nicolau, D. P., Viale, P. L., Giamarellos-Bourboulis EJ, Tumbarello, M, H. Giamarellou, Daikos, G. L, I. Karaiskos, Viale, P. L, De Rosa, F. G., G. Poulakou, D.R. Giacobbe, Righi E, Giacobbe, D. R., Tumbarello, M., Giamarellou, H., Dimopoulos, G., C. Viscoli, Karaiskos I, BASSETTI, MATTEO, Karaiskos, I, Bassetti M, M. Bassetti, G.M. Rossolini, Karaiskos, I., Viscoli, C, F.G. De Rosa, Giamarellos-Bourboulis, E. J., De Rosa, F. G, E. Righi, Giacobbe DR, Giamarellos Bourboulis, E. J, D.P. Nicolau, De Rosa FG, Rossolini GM, Rossolini, G. M, Viscoli C, Righi, E., Rossolini, G. M., Daikos GL, Poulakou, G., M. Tumbarello, Giamarellou, H, Tumbarello M, Nicolau DP, Poulakou G, G. Dimopoulos, Viscoli, C., Viale PL, Giamarellou H, Nicolau, D. P, P.L. Viale, Dimopoulos, G, G.L. Daikos, Dimopoulos G, Righi, E, Bassetti, M., Daikos, G. L.   +58 more
core   +1 more source

Triazole-substituted phenylboronic acids as tunable lead inhibitors of KPC-2 antibiotic resistance [PDF]

, 2022
Inhibition of β-lactamases is a promising strategy to overcome antimicrobial resistance to commonly used β-lactam antibiotics. Boronic acid derivatives have proven to be effective inhibitors of β-lactamases due to their direct interaction with the ...
Zhou, Jingyuan, Stapleton, Paul, Schatzlein, Andreas, Haider, Shozeb, Healy, Jess, Xavier-Junior, Francisco Humberto, Wells, Geoffrey   +6 more
core  

New Small Plasmid Harboring bla(KPC-2) in Pseudomonas aeruginosa

, 2016
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Processo FAPESP: 2014/14494-8The aim of this study was to characterize the genetic context of bla(KPC-2) in Pseudomonas aeruginosa sequence type 244 from Brazil.
Chandler, Michael, Varani, Alessandro de Mello, Costa Darini, Ana Lucia, Galetti, Renata, Andrade, Leonardo Neves, Varani, Alessandro de Mello [UNESP]   +5 more
core   +1 more source