Results 81 to 90 of about 34,694 (215)
Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer
Advanced Science, EarlyView.Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen +13 more
wiley +1 more source
The far-infrared - radio correlation in dwarf galaxies
, 2016 The far-infrared - radio correlation connects star formation and magnetic fields in galaxies, and has been confirmed over a large range of far-infrared luminosities.
Beck, Rainer, Schleicher, Dominik R. G.
core +1 more source
First Report of KPC-2-Producing Klebsiella pneumoniae Strains in Brazil [PDF]
Antimicrobial Agents and Chemotherapy, 2009 The carbapenems are regarded as the preferential therapeutic option for treatment of serious health care-associated infections with multidrug-resistant gram-negative bacteria. Although carbapenem resistance is rarely described for the Enterobacteriaceae ([6][1]), this phenotype of resistance ...
Jussimara, Monteiro +4 more
openaire +2 more sources
Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity
Advanced Science, EarlyView.This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao +11 more
wiley +1 more source
Early Dissemination of KPC-2-Producing Klebsiella pneumoniae Strains in Brazil [PDF]
Antimicrobial Agents and Chemotherapy, 2009 A recent publication by Monteiro et al. reported the first detection of KPC-2 β-lactamase in carbapenem-resistant Klebsiella pneumoniae strains in Brazil, which occurred in 2006 ([5][1]).
Mónica, Pavez +2 more
openaire +3 more sources
Infection and Drug Resistance, 2020 Ziyan Kong,1,2,* Xuemei Liu,3,* Chenxi Li,1,* Siyun Cheng,1 Fei Xu,3 Bing Gu1,4 1Medical Technology School, Xuzhou Medical University, Xuzhou, Jiangsu Province, People’s Republic of China; 2Department of Laboratory Medicine, The First People&rsquo ...
Kong Z, Liu X, Li C, Cheng S, Xu F, Gu B
doaj
Advanced Science, EarlyView.Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou +10 more
wiley +1 more source
Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates [PDF]
, 2013 Antibiotic resistance is one of the main problems concerning public health or clinical practice. Antimicrobial peptides appear as good candidates for the development of new therapeutic drugs.
Corso, Alejandra +7 more
core +1 more source
Plasmid-Mediated KPC-2 in a Klebsiella pneumoniae Isolate from China [PDF]
Antimicrobial Agents and Chemotherapy, 2007 ABSTRACT A carbapenem-resistant isolate of Klebsiella pneumoniae producing class A carbapenemase KPC-2 was identified in Zhejiang, China. The KPC-2 gene was located on an approximately 60-kb plasmid in a genetic environment partially different from that of bla KPC-2 in ...
Ze-Qing, Wei +5 more
openaire +2 more sources
npj Antimicrobials and ResistanceCeftazidime-avibactam (CZA) is currently one of the last resorts used to treat infections caused by carbapenem-resistant Enterobacteriaceae and Pseudomonas aeruginosa.
Longjie Zhou +10 more
doaj +1 more source