Results 81 to 90 of about 24,464,352 (186)

Identification of a Novel KPC Variant, KPC-204, Conferring Resistance to Both Carbapenems and Ceftazidime–Avibactam in an ST11 Klebsiella pneumoniae Strain

Microorganisms
This study describes KPC-204, a novel variant of Klebsiella pneumoniae carbapenemase, characterized by a Lys-Asp-Asp (KDD) amino acid insertion at Ambler position 269 deviates from KPC-2.
Yanqiao Gong, Yu Feng, Xiaoju Lv
doaj   +1 more source

High prevalence of KPC-2-producing hypervirulent Klebsiella pneumoniae causing meningitis in Eastern China

, 2019
Min Xu,1,* Yiqi Fu,2,* Yunhui Fang,3 Hao Xu,3 Haishen Kong,3 Yanchao Liu,1 Yu Chen,1,3 Lanjuan Li3 1Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Center of Clinical Laboratory, The First Affiliated Hospital, College of ...
Fang Y, Liu Y, Xu M, Fu Y, Chen Y, Xu H, Li L, Kong H   +7 more
core  

Emergence of Escherichia coli Sequence Type 131 (ST131) and ST3948 with KPC-2, KPC-3 and KPC-8 carbapenemases from a Long-Term Care and Rehabilitation Facility (LTCRF) in Northern Italy [PDF]

, 2016
Aim of the study was to characterize KPC-producing Escherichia coli (KPC-Ec) clinical isolates among a Northern Italy Long-Term Care and Rehabilitation Facility (LTCRF) residents. Thirteen consecutive non repeated MDR E.
Roberto D’Angelo, Melissa Spalla, Laura Pagani, Ibrahim Bitar, D'Angelo, Roberto, Aurora Piazza, BITAR, IBRAHIM, SPALLA, MELISSA, Roberta Migliavacca, PIAZZA, AURORA, NUCLEO, ELISABETTA, Mariasofia Caltagirone, Elena Fogato, CALTAGIRONE, MARIASOFIA, Fogato, Elena, Elisabetta Nucleo, MIGLIAVACCA, ROBERTA, PAGANI, LAURA   +17 more
core   +1 more source

Characteristic of KPC-12, a KPC Variant Conferring Resistance to Ceftazidime-Avibactam in the Carbapenem-Resistant Klebsiella pneumoniae ST11-KL47 Clone Background [PDF]

Weihua Han,1,* Peiyao Zhou,2,* Chun Chen,3,* Chunyang Wu,2 Li Shen,1 Cailing Wan,4 Yanghua Xiao,4 Jiao Zhang,2 Bingjie Wang,1 Junhong Shi,1 Xinru Yuan,1 Haojin Gao,1 Hongxiu Wang,1 Ying Zhou,1 Fangyou Yu1 1Department of Clinical Laboratory ...
Shen L, Zhou P, Zhang J, Wang B, Xiao Y, Han W, Wu C, Yu F, Gao H, Wang H, Chen C, Zhou Y, Wan C, Shi J, Yuan X   +14 more
core  

Diverse evolutionary trajectories of Klebsiella pneumoniae carbapenemase: unraveling the impact of amino acid substitutions on β-lactam susceptibility and the role of avibactam in driving resistance

mSystems
Klebsiella pneumoniae carbapenemases (KPCs) have evolved into over 245 distinct variants, with over one-third of variants exhibiting reduced susceptibility to ceftazidime-avibactam, while the underlying selection mechanisms remain elusive.
Jie Wei, Jinyu Huang, Chunhong Zou, Shimei Shen, Barry N. Kreiswirth, Ailong Huang, Shifeng Huang, Liang Chen, Deqiang Wang, Siqiang Niu   +9 more
doaj   +1 more source

ST11 KPC-2-Producing Klebsiella pneumoniae Isolated from Patient with Acute Myelocytic Leukemia

Infection and Drug Resistance
Can Chen,1 Fan Yang,1 Mantao Chen,2 Ying Xu,1 Yaping Xie,1 Ruishan Liu,3 Pengfei Shi,1 Shenxian Qian1 1Department of Hematology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, People’s ...
Chen C, Yang F, Chen M, Xu Y, Xie Y, Liu R, Shi P, Qian S   +7 more
doaj  

Isolation of a Ceftazidime-Avibactam-Resistant blaKPC-71-Positive Klebsiella pneumoniae Clinical Isolate

Microbiology Spectrum, 2022
Siquan Shen, Qingyu Shi, Renru Han, Yan Guo, Yang Yang, Shi Wu, Dandan Yin, Fupin Hu   +7 more
doaj   +1 more source

KPC-2 producing ST101 Klebsiella pneumoniae from bloodstream infection in India

Journal of Medical Microbiology, 2018
This study characterizes KPC-2 producing Klebsiella pneumoniae belonging to ST101. Whole genome sequencing using the Ion Torrent PGM platform with 400 bp chemistry was performed. blaKPC-2 was found on an IncFIIK plasmid associated with ISKpn6 and ISKpn7 without Tn4401. This is the first report of KPC-2 K. pneumoniae from bacteremia in India.
Chaitra, Shankar, Baby Abirami, Shankar, Abi, Manesh, Balaji, Veeraraghavan   +3 more
openaire   +2 more sources

Emergence of Carbapenemase Producing Klebsiella Pneumonia and Spread of KPC-2 and KPC-17 in Taiwan: A Nationwide Study from 2011 to 2013. [PDF]

, 2015
The emergence of carbapenemase-producing Klebsiella pneumoniae (CPKP) has become a great concern worldwide. In this study, 994 non-duplicate, carbapenem non-susceptible Klebsiella pneumonia isolates were collected in Taiwan from 2011 to 2013 for ...
Shiow-Jen Wang, Hung-Yi Yeh, I-Ling Tseng (407753), Jung-Jung Mu, Yu-Chuan Tseng (797450), Yu-Mei Liu, Jung-Jung Mu (768010), Shiow-Jen Wang (797446), Hsueh-Lin Lu (797449), Chia-Lun Hsieh, Yu-Chuan Tseng, Hung-Yi Yeh (797447), Yu-Mei Liu (797445), Chia-Lun Hsieh (797448), I-Ling Tseng, Hsueh-Lin Lu   +15 more
core   +1 more source

Pharmacophore hypothesis for KPC-2 ligands.

, 2018
Binding site of KPC-2 (PDB code 3RXW, blue) superimposed with a fragment of the ligand OJ6 bound to CTX-M-9 β-lactamase (PDB code 4DE1, cyan) and pharmacophore features (red: hydrogen-bond acceptor, orange: hydrophobic interaction feature, purple ...
Pasquale Linciano (4426435), Giuseppe Celenza (4632985), Jesus Blazquez (6029207), Raphael Klein (5793428), Pierangelo Bellio (4632979), Laura Cendron (222504), Sofia Papaioannou (6029204), Ruth Brenk (325207), Donatella Tondi (2467822)   +8 more
core   +1 more source