Results 61 to 70 of about 24,464,352 (186)

Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains.

PLoS ONE, 2019
Alterations of the PALB2 tumor suppressor gene have been identified in familial breast, ovarian and pancreatic cancer cases. PALB2 cooperates with BRCA1/2 proteins through physical interaction in initiation of homologous recombination, in maintenance of ...
Dongju Park, Reena Shakya, Christopher Koivisto, Jason R Pitarresi, Matthias Szabolcs, Raleigh Kladney, Ashley Hadjis, Thomas A Mace, Thomas Ludwig   +8 more
doaj   +1 more source

Unravelling ceftazidime/avibactam resistance of KPC-28, a KPC-2 variant lacking carbapenemase activity

, 2019
International audienceBACKGROUND:KPC-like carbapenemases have spread worldwide with more than 30 variants identified that differ by single or double amino-acid substitutions.OBJECTIVES:To describe the steady-state kinetic parameters of KPC-28, which ...
Tlili, Linda, Jousset, Agnès, Zavala, Agustin, Dortet, Laurent, Bernabeu, Sandrine, Naas, Thierry, Exilie, Cynthia, Oueslati, Saoussen, Iorga, Bogdan, Bonnin, Rémy   +9 more
core   +1 more source

Resolved gamma ray emission of the supernova remnant W51C and HESS J1857+026 obtained with the MAGIC telescopes [PDF]

, 2013
Diese Dissertation untersucht den Urspung der kosmischen Strahlung mit Beobachtungen der MAGIC Teleskope im Bereich der hoch energeticher Gammastrahlenastronomie. Gammastrahlung wird bei der Wechselwirkung relativistischer Teilchen erzeugt.
Krause, Julian D. G.
core   +1 more source

Within-host co-evolution of KPC variants: plasmid-mediated dissemination of blaKpc-194 and blaKpc-33 in ST11-KL64 hypervirulent Klebsiella pneumoniae driving ceftazidime-avibactam resistance

Microbiology Spectrum
KPC variants are the primary cause of treatment failure in patients with Klebsiella pneumoniae infections. This study reports the molecular mechanism by which two novel KPC variants (KPC-194 and KPC-33), isolated from a single patient, mediate resistance
Li Ding, Xiangbing Wu, Qiang Xie, Liting Liu, Bingshao Liang, Siquan Shen, Yan Guo, Jing Chen, Fupin Hu   +8 more
doaj   +1 more source

Emergence and clonal dissemination of KPC-3-producing Pseudomonas aeruginosa in China with an IncP-2 megaplasmid

Annals of Clinical Microbiology and Antimicrobials, 2023
Background Despite the global prevalence of Klebsiella pneumoniae Carbapenemase (KPC)-type class A β-lactamases, occurrences of KPC-3-producing isolates in China remain infrequent. This study aims to explore the emergence, antibiotic resistance profiles,
Haoyu Ge, Jie Qiao, Jiahao Zheng, Hao Xu, Ruishan Liu, Junhui Zhao, Ruyan Chen, Chenyu Li, Xiaobing Guo, Beiwen Zheng   +9 more
doaj   +1 more source

Identification of a KPC Variant Conferring Resistance to Ceftazidime-Avibactam from ST11 Carbapenem-Resistant Klebsiella pneumoniae Strains

Microbiology Spectrum, 2022
A novel Klebsiella pneumoniae carbapenemase (KPC) variant, KPC-93, was identified in two Klebsiella pneumoniae clinical isolates from a patient from China treated with ceftazidime-avibactam.
Yuchen Wu, Xuemei Yang, Congcong Liu, Yanyan Zhang, Yan Chu Cheung, Edward Wai Chi Chan, Sheng Chen, Rong Zhang   +7 more
doaj   +1 more source

Inter-hospital outbreak of Klebsiella pneumoniae producing KPC-2 carbapenemase in Ireland [PDF]

Journal of Antimicrobial Chemotherapy, 2012
To describe an outbreak of KPC-2-producing Klebsiella pneumoniae with inter-hospital spread and measures taken to control transmission. Between January and March 2011, 13 K. pneumoniae isolates were collected from nine patients at hospital A and two patients at hospital B.
Morris, D., Boyle, F., Morris, C., Condon, I., Delannoy-Vieillard, A.-S., Power, L., Khan, A., Morris-Downes, M., Finnegan, C., Powell, J., Monahan, R., Burns, K., O'Connell, N., Boyle, L., O'Gorman, A., Humphreys, H., Brisse, S., Turton, J., Woodford, N., Cormican, M.   +19 more
openaire   +3 more sources

Emergence of Ceftazidime- and Avibactam-Resistant Klebsiella pneumoniae Carbapenemase-Producing Pseudomonas aeruginosa in China

mSystems, 2021
Klebsiella pneumoniae carbapenemase (KPC)-producing Pseudomonas aeruginosa (KPC-PA) has been reported sporadically. However, epidemiological and antimicrobial susceptibility data specific for KPC-PA are lacking.
Yiwei Zhu, Jie Chen, Han Shen, Zhongju Chen, Qi-wen Yang, Jin Zhu, Xi Li, Qing Yang, Feng Zhao, Jingshu Ji, Heng Cai, Yue Li, Linghong Zhang, Sebastian Leptihn, Xiaoting Hua, Yunsong Yu   +15 more
doaj   +1 more source

Emergence of a KPC Variant Conferring Resistance to Ceftazidime-Avibactam in a Widespread ST11 Carbapenem-Resistant Klebsiella pneumoniae Clone in China

Frontiers in Microbiology, 2021
Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection poses a great threat to public health worldwide, and KPC-2-producing strains are the main factors responsible for resistance to carbapenems in China.
Xi Li, Jingjing Quan, Jingjing Quan, Jingjing Quan, Huanhuan Ke, Huanhuan Ke, Wenhao Wu, Yu Feng, Yu Feng, Yunsong Yu, Yunsong Yu, Yunsong Yu, Yan Jiang, Yan Jiang, Yan Jiang   +14 more
doaj   +1 more source

800 QM/MM minimum energy pathway conformations for the deacylation reactions of KPC-2/Imipenem

, 2022
The datasets comprise 800 coordinate files (in the CHARMM psf/cor format) for the QM/MM minimum energy pathways of the deacylation reactions between a Class A beta-lactamases (KPC wild type (KPC-WT) and KPC Phe72Tyr mutant (KPC-F72Y)) and the imipenem ...
Chao Yin
core   +1 more source