Results 61 to 70 of about 17,687,028 (211)

Identification of a KPC Variant Conferring Resistance to Ceftazidime-Avibactam from ST11 Carbapenem-Resistant Klebsiella pneumoniae Strains

Microbiology Spectrum, 2022
A novel Klebsiella pneumoniae carbapenemase (KPC) variant, KPC-93, was identified in two Klebsiella pneumoniae clinical isolates from a patient from China treated with ceftazidime-avibactam.
Yuchen Wu, Xuemei Yang, Congcong Liu, Yanyan Zhang, Yan Chu Cheung, Edward Wai Chi Chan, Sheng Chen, Rong Zhang   +7 more
doaj   +1 more source

Inhibition of Focal Adhesion Restricts Chemoresistance in Pancreatic Cancer by Targeting SLC7A11 Mediated Ferroptosis

Advanced Science, EarlyView.
FAK signaling drives chemoresistance and tumor evolution in pancreatic ductal adenocarcinoma. The FAK inhibitor IN10018 restores gemcitabine sensitivity by inducing SLC7A11‐mediated ferroptosis through the PI3K‐Akt pathway and remodeling the tumor microenvironment, reducing mesenchymal components while enhancing CD8+ T‐cell infiltration in preclinical ...
Yingjin Wang, Hui Yang, Baoyuan Zhang, Yongsu Ma, Kuangen Zhang, Peng Wang, Jiapeng Yang, Zaiqi Wang, Rong Liu, Xiaodong Tian, Ning Zhang, Yinmo Yang   +11 more
wiley   +1 more source

Plasmid DNA profiles from 4 KPC-17 and 2 KPC-2 isolates in PT1.

, 2015
HindIII restriction mapping of transformed plasmids from 4 KPC-17 and 2 KPC-2 isolates selected from PT1.
Hsueh-Lin Lu (797449), I-Ling Tseng (407753), Hung-Yi Yeh (797447), Yu-Mei Liu (797445), Chia-Lun Hsieh (797448), Yu-Chuan Tseng (797450), Jung-Jung Mu (768010), Shiow-Jen Wang (797446)   +7 more
core   +1 more source

Within-host co-evolution of KPC variants: plasmid-mediated dissemination of blaKpc-194 and blaKpc-33 in ST11-KL64 hypervirulent Klebsiella pneumoniae driving ceftazidime-avibactam resistance

Microbiology Spectrum
KPC variants are the primary cause of treatment failure in patients with Klebsiella pneumoniae infections. This study reports the molecular mechanism by which two novel KPC variants (KPC-194 and KPC-33), isolated from a single patient, mediate resistance
Li Ding, Xiangbing Wu, Qiang Xie, Liting Liu, Bingshao Liang, Siquan Shen, Yan Guo, Jing Chen, Fupin Hu   +8 more
doaj   +1 more source

Emergence and clonal dissemination of KPC-3-producing Pseudomonas aeruginosa in China with an IncP-2 megaplasmid

Annals of Clinical Microbiology and Antimicrobials, 2023
Background Despite the global prevalence of Klebsiella pneumoniae Carbapenemase (KPC)-type class A β-lactamases, occurrences of KPC-3-producing isolates in China remain infrequent. This study aims to explore the emergence, antibiotic resistance profiles,
Haoyu Ge, Jie Qiao, Jiahao Zheng, Hao Xu, Ruishan Liu, Junhui Zhao, Ruyan Chen, Chenyu Li, Xiaobing Guo, Beiwen Zheng   +9 more
doaj   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Unravelling ceftazidime/avibactam resistance of KPC-28, a KPC-2 variant lacking carbapenemase activity

, 2019
International audienceBACKGROUND:KPC-like carbapenemases have spread worldwide with more than 30 variants identified that differ by single or double amino-acid substitutions.OBJECTIVES:To describe the steady-state kinetic parameters of KPC-28, which ...
Tlili, Linda, Jousset, Agnès, Zavala, Agustin, Dortet, Laurent, Bernabeu, Sandrine, Naas, Thierry, Exilie, Cynthia, Oueslati, Saoussen, Iorga, Bogdan, Bonnin, Rémy   +9 more
core   +1 more source

Emergence of a KPC Variant Conferring Resistance to Ceftazidime-Avibactam in a Widespread ST11 Carbapenem-Resistant Klebsiella pneumoniae Clone in China

Frontiers in Microbiology, 2021
Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection poses a great threat to public health worldwide, and KPC-2-producing strains are the main factors responsible for resistance to carbapenems in China.
Xi Li, Jingjing Quan, Jingjing Quan, Jingjing Quan, Huanhuan Ke, Huanhuan Ke, Wenhao Wu, Yu Feng, Yu Feng, Yunsong Yu, Yunsong Yu, Yunsong Yu, Yan Jiang, Yan Jiang, Yan Jiang   +14 more
doaj   +1 more source

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, EarlyView.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source

Melting temperatures of KPC-2 and variants.

, 2015
Melting temperatures of KPC-2 and variants.
Timothy Palzkill (47788), Shrenik C. Mehta (747991), Kacie Rice (747992)   +2 more
core   +1 more source