Results 61 to 70 of about 34,694 (215)

Deep into the structure of the first galaxies: SERRA views [PDF]

open access: yes, 2019
We study the formation and evolution of a sample of Lyman Break Galaxies in the Epoch of Reionization by using high-resolution ($\sim 10 \,{\rm pc}$), cosmological zoom-in simulations part of the SERRA suite.
Behrens, C.   +8 more
core   +3 more sources

First report of Klebsiella quasipneumoniae harboring bla KPC-2 in Saudi Arabia

open access: yesAntimicrobial Resistance and Infection Control, 2019
Background Nosocomial infections caused by multi-drug resistant Enterobacteriaceae are a global public health threat that ought to be promptly identified, reported, and addressed accurately.
Sharif Hala   +10 more
doaj   +1 more source

Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains.

open access: yesPLoS ONE, 2019
Alterations of the PALB2 tumor suppressor gene have been identified in familial breast, ovarian and pancreatic cancer cases. PALB2 cooperates with BRCA1/2 proteins through physical interaction in initiation of homologous recombination, in maintenance of ...
Dongju Park   +8 more
doaj   +1 more source

Emergence and clonal dissemination of KPC-3-producing Pseudomonas aeruginosa in China with an IncP-2 megaplasmid

open access: yesAnnals of Clinical Microbiology and Antimicrobials, 2023
Background Despite the global prevalence of Klebsiella pneumoniae Carbapenemase (KPC)-type class A β-lactamases, occurrences of KPC-3-producing isolates in China remain infrequent. This study aims to explore the emergence, antibiotic resistance profiles,
Haoyu Ge   +9 more
doaj   +1 more source

Identification of a KPC Variant Conferring Resistance to Ceftazidime-Avibactam from ST11 Carbapenem-Resistant Klebsiella pneumoniae Strains

open access: yesMicrobiology Spectrum, 2022
A novel Klebsiella pneumoniae carbapenemase (KPC) variant, KPC-93, was identified in two Klebsiella pneumoniae clinical isolates from a patient from China treated with ceftazidime-avibactam.
Yuchen Wu   +7 more
doaj   +1 more source

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

open access: yesAdvanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade   +19 more
wiley   +1 more source

Calibrating the relation of low-frequency radio continuum to star formation rate at 1 kpc scale with LOFAR [PDF]

open access: yes, 2018
9 figures, 6 tables and 17 pages. This paper is part of the LOFAR surveys data release 1 and has been accepted for publication in a special edition of A&A that will appear in Feb 2019, volume 622.
Basu, A.   +18 more
core   +7 more sources

KPC-2 producing ST101 Klebsiella pneumoniae from bloodstream infection in India

open access: yesJournal of Medical Microbiology, 2018
This study characterizes KPC-2 producing Klebsiella pneumoniae belonging to ST101. Whole genome sequencing using the Ion Torrent PGM platform with 400 bp chemistry was performed. blaKPC-2 was found on an IncFIIK plasmid associated with ISKpn6 and ISKpn7 without Tn4401. This is the first report of KPC-2 K. pneumoniae from bacteremia in India.
Chaitra, Shankar   +3 more
openaire   +2 more sources

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto   +20 more
wiley   +1 more source

Insights into a Novel blaKPC-2-Encoding IncP-6 Plasmid Reveal Carbapenem-Resistance Circulation in Several Enterobacteriaceae Species from Wastewater and a Hospital Source in Spain [PDF]

open access: yes, 2017
Untreated wastewater, particularly from hospitals and other healthcare facilities, is considered to be a reservoir for multidrug-resistant bacteria.
Cantón, Rafael   +8 more
core   +1 more source

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