Results 51 to 60 of about 17,687,028 (211)

The Structural Role of N170 in Substrate‐Assisted Deacylation in KPC‐2 β‐Lactamase

Angewandte Chemie, 2023
AbstractThe amino acid substitutions in Klebsiella pneumoniae carbapenemase 2 (KPC‐2) that have arisen in the clinic are observed to lead to the development of resistance to ceftazidime‐avibactam, a preferred treatment for KPC bearing Gram‐negative bacteria.
Diksha Parwana, Jing Gu, Shuang Chen, Christopher R. Bethel, Emma Marshall, Andrea M. Hujer, Robert A. Bonomo, Shozeb Haider   +7 more
openaire   +3 more sources

Shift in the Dominant Sequence Type of Carbapenem-Resistant Klebsiella pneumoniae Bloodstream Infection from ST11 to ST15 at a Medical Center in Northeast China, 2015–2020

Infection and Drug Resistance, 2021
Jingjing Chen,1– 3 Chang Hu,1– 3 Ruixuan Wang,1– 3 Fushun Li,1– 3 Guoquan Sun,1– 3 Min Yang,1– 3 Yunzhuo Chu1– 3 1Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University ...
Chen J, Hu C, Wang R, Li F, Sun G, Yang M, Chu Y   +6 more
doaj  

Emergence of KPC-2-Producing Salmonella enterica Serotype Schwarzengrund in Argentina [PDF]

Antimicrobial Agents and Chemotherapy, 2014
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Jure, M A, Duprilot, M, Musa, H E, López, C, de Castillo, Marta C, Weill, François-Xavier, Arlet, G, Decré, D   +7 more
openaire   +2 more sources

Kinetic parameters for KPC-15 and KPC-2 enzymes.

, 2014
Kinetic parameters for KPC-15 and KPC-2 enzymes.
Linjun Yang (652707), Dongguo Wang (652706), Jiayu Chen (106469), Yonghua Mou (652708), Yijun Yang (187046)   +4 more
core   +1 more source

800 QM/MM minimum energy pathway conformations for the deacylation reactions of KPC-2/Imipenem

, 2022
The datasets comprise 800 coordinate files (in the CHARMM psf/cor format) for the QM/MM minimum energy pathways of the deacylation reactions between a Class A beta-lactamases (KPC wild type (KPC-WT) and KPC Phe72Tyr mutant (KPC-F72Y)) and the imipenem ...
Chao Yin
core   +1 more source

In vivo Selection of Imipenem Resistance Among Ceftazidime-Avibactam-Resistant, Imipenem-Susceptible Klebsiella pneumoniae Isolate With KPC-33 Carbapenemase

Frontiers in Microbiology, 2021
We describe in vivo evolution of carbapenem and ceftazidime-avibactam resistance by analyzing four longitudinal Klebsiella pneumoniae clinical isolates from a patient with pneumonia following antimicrobial treatment.
Chunlei Wang, Chunlei Wang, Chunlei Wang, Chunlei Wang, Jiankang Zhao, Jiankang Zhao, Jiankang Zhao, Jiankang Zhao, Zhibo Liu, Zhibo Liu, Zhibo Liu, Aihua Sun, Aihua Sun, Aihua Sun, Lingxiao Sun, Lingxiao Sun, Lingxiao Sun, Lingxiao Sun, Binbin Li, Binbin Li, Binbin Li, Binbin Li, Binghuai Lu, Binghuai Lu, Binghuai Lu, Binghuai Lu, Yingmei Liu, Yingmei Liu, Yingmei Liu, Yingmei Liu, Bin Cao, Bin Cao, Bin Cao, Bin Cao   +33 more
doaj   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

KPC-2-producing Klebsiella pneumoniae ST11 in a Children’s Hospital in Poland [PDF]

Polish Journal of Microbiology, 2017
Abstract Four Klebsiella pneumoniae isolates from children hospitalized over 10 months in an intensive care unit in a children’s teaching hospital in Poland were analyzed. All of the isolates belonged to a single pulsotype and sequence type (ST) 11, and produced the KPC-2 ...
MACHULSKA, MONIKA, BARANIAK, ANNA, ŻAK, IWONA, BOJARSKA, KATARZYNA, ŻABICKA, DOROTA, SOWA-SIERANT, IWONA, HRYNIEWICZ, WALERIA, GNIADKOWSKI, MAREK   +7 more
openaire   +4 more sources

First report of Klebsiella quasipneumoniae harboring bla KPC-2 in Saudi Arabia

Antimicrobial Resistance and Infection Control, 2019
Background Nosocomial infections caused by multi-drug resistant Enterobacteriaceae are a global public health threat that ought to be promptly identified, reported, and addressed accurately.
Sharif Hala, Chakkiath Paul Antony, Mohammed Alshehri, Abdulhakeem O. Althaqafi, Asim Alsaedi, Areej Mufti, Mai Kaaki, Baraa T. Alhaj-Hussein, Hosam M. Zowawi, Abdulfattah Al-Amri, Arnab Pain   +10 more
doaj   +1 more source

Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains.

PLoS ONE, 2019
Alterations of the PALB2 tumor suppressor gene have been identified in familial breast, ovarian and pancreatic cancer cases. PALB2 cooperates with BRCA1/2 proteins through physical interaction in initiation of homologous recombination, in maintenance of ...
Dongju Park, Reena Shakya, Christopher Koivisto, Jason R Pitarresi, Matthias Szabolcs, Raleigh Kladney, Ashley Hadjis, Thomas A Mace, Thomas Ludwig   +8 more
doaj   +1 more source