Results 41 to 50 of about 24,464,352 (186)

KPC-derived organoid tumor histopathology features.

, 2020
KPC-derived organoid tumor stained for hyaluronic acid (A), pimonidazole (B), collagen (green) and Meca32 (red) (C). Co-staining of pimonidazole (green) and Meca-32 (red) (D) showing vessels present in both oxic and hypoxic tissue. Black scale bar = 5 mm.
John L. Humm (8720559), Kenneth H. Yu (1266099), James Russell (326068), Isabella O’Donoghue (8720556), Nagavarakishore Pillarsetty (2185546), Kishore Gangangari (5696168), Louise M. Fanchon (8720553)   +6 more
core   +1 more source

First Report of KPC-2 Carbapenemase-Producing Klebsiella pneumoniae in Japan [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT We investigated a novel Japanese isolate of sequence type 11 (ST11), the Klebsiella pneumoniae carbapenemase-2 (KPC-2)-producing K. pneumoniae strain Kp3018, which was previously obtained from a patient treated at a Brazilian hospital.
Ryoichi, Saito, Rieko, Takahashi, Etsuko, Sawabe, Saho, Koyano, Yutaka, Takahashi, Mari, Shima, Hiroto, Ushizawa, Toshihide, Fujie, Naoki, Tosaka, Yuko, Kato, Kyoji, Moriya, Shuji, Tohda, Naoko, Tojo, Ryuji, Koike, Tetsuo, Kubota   +14 more
openaire   +2 more sources

Prevalence of bla_KPC-2, bla_KPC-3 and bla_KPC-30—Carrying Plasmids in Klebsiella pneumoniae Isolated in a Brazilian Hospital

Pathogens, 2021
Klebsiella pneumoniae carbapenemase (KPC) actively hydrolyzes carbapenems, antibiotics often used a last-line treatment for multidrug-resistant bacteria. KPC clinical relevance resides in its widespread dissemination.
Letícia B. Migliorini, Romário O. de Sales, Paula C. M. Koga, Andre M. Doi, Anja Poehlein, Alexandra R. Toniolo, Fernando G. Menezes, Marines D. V. Martino, Ana C. Gales, Holger Brüggemann, Patricia Severino   +10 more
doaj   +1 more source

Identification of carbapenemase KPC-2 encoding plasmids among environmental Enterobacteriaceae

, 2022
Pojava rezistentnih sojeva Enterobacteriaceae posljedica je nerijetke uporabe karbapenemskih antibiotika u kliničkoj praksi. Karbapenemaze hidroliziraju karbapenemske antibiotike, a geni koji ih kodiraju su povezani s visokorizičnim klonovima i šire se
Bellulovich, Ema
core   +2 more sources

Rapid Detection of bla_KPC-9 Allele from Clinical Isolates

Pathogens, 2021
The emergence of Klebsiella pneumoniae carbapenemase (KPC) nosocomial outbreaks related to specific blaKPC gene variants dictates the need for applicable diagnostic methods for allele discrimination.
Konstantina Gartzonika, Petros Bozidis, Ephthalia Priavali, Hercules Sakkas   +3 more
doaj   +1 more source

Relebactam is a potent inhibitor of the kpc-2 -lactamase and restores imipenem susceptibility in kpc-producing enterobacteriaceae [PDF]

, 2018
The imipenem-relebactam combination is in development as a potential treatment regimen for infections caused by Enterobacteriaceae possessing complex -lactamase backgrounds. Relebactam is a -lactamase inhibitor that possesses the diazabicyclooctane core,
Alsop J., Papp-Wallace K.M., van Duin D., Kaye K.S., Bethel C.R., Bonomo R.A., Taracila M.A., Kreiswirth B.N., Barnes M.D., Becka S.A.   +9 more
core   +1 more source

Resistance Phenotype and Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniae Isolated from Nanjing Children’s Hospital in Jiangsu Province, China

Infection and Drug Resistance, 2022
Guixiang Tao,1 Hua Tan,2 Jingjing Ma,1 Qian Chen1 1Institute of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Laboratory Medicine, Children’s Hospital of Nanjing Medical University ...
Tao G, Tan H, Ma J, Chen Q
doaj  

Identification of Two Novel Carbapenemase-Encoding Hybrid Plasmids Harboring blaNDM-5 and blaKPC-2 in a Clinical ST11-KL47 Klebsiella pneumoniae

Infection and Drug Resistance, 2023
Weiqiang Xiao,1,* Xiaokun Wang,1,* Yuanye Qu,1 Mingyue Sun,1 Yanmin Chang,1 Wenjiao Li,1 Yong Shen,1,2 Xiufang Shi,3 Min Jing,1 Qingxia Xu1,4 1Department of Clinical Laboratory, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou ...
Xiao W, Wang X, Qu Y, Sun M, Chang Y, Li W, Shen Y, Shi X, Jing M, Xu Q   +9 more
doaj  

Characterization of the two tandem repeats for the KPC-2 core structures on a plasmid from hospital-derived Klebsiella pneumoniae

Scientific Reports, 2023
Today, Klebsiella pneumoniae strains are sophisticatedly associated with the transmission of KPC, and ST11 clones carrying KPC-2 are an important target for anti-infective clinical therapy, posing a very high threat to patients.
Liman Ma, Wenji Wang, Ying Qu, Dongguo Wang   +3 more
doaj   +1 more source

The Structural Role of N170 in Substrate‐Assisted Deacylation in KPC‐2 β‐Lactamase

Angewandte Chemie, 2023
AbstractThe amino acid substitutions in Klebsiella pneumoniae carbapenemase 2 (KPC‐2) that have arisen in the clinic are observed to lead to the development of resistance to ceftazidime‐avibactam, a preferred treatment for KPC bearing Gram‐negative bacteria.
Diksha Parwana, Jing Gu, Shuang Chen, Christopher R. Bethel, Emma Marshall, Andrea M. Hujer, Robert A. Bonomo, Shozeb Haider   +7 more
openaire   +3 more sources