Results 21 to 30 of about 17,687,028 (211)

In vivo transmission of a plasmid containing the KPC-2 gene in a single patient

Journal of Global Antimicrobial Resistance, 2013
Here we describe a case of in vivo horizontal interspecies transmission of a KPC-2-producing plasmid from a Klebsiella pneumoniae to an Enterobacter aerogenes strain in the same patient. The patient's gut flora initially contained a carbapenem-susceptible E. aerogenes strain and 10 days after admission a KPC-2-positive K. pneumoniae. Three months after
Irene, Galani, Theofano, Panagea, Zoi, Chryssouli, Helen, Giamarellou, Maria, Souli   +4 more
openaire   +3 more sources

KPC-2-NDM-1-producing Serratia marcescens: first description in Peru

New Microbes and New Infections, 2022
Two clonal extensively-resistant S. marcescens were isolated in Peru. The presence and transferability of extended-spectrum β-lactamases and IMP, KPC, NDM, OXA-48 and VIM were determined.
Barbara Ymaña, Nestor Luque, Maria J. Pons, Joaquim Ruiz   +3 more
doaj   +2 more sources

In silico identification and experimental validation of hits active against KPC-2 β-lactamase. [PDF]

PLoS ONE, 2018
Bacterial resistance has become a worldwide concern, particularly after the emergence of resistant strains overproducing carbapenemases. Among these, the KPC-2 carbapenemase represents a significant clinical challenge, being characterized by a broad ...
Raphael Klein, Pasquale Linciano, Giuseppe Celenza, Pierangelo Bellio, Sofia Papaioannou, Jesus Blazquez, Laura Cendron, Ruth Brenk, Donatella Tondi   +8 more
doaj   +2 more sources

Emergence of Carbapenemase Producing Klebsiella Pneumonia and Spread of KPC-2 and KPC-17 in Taiwan: A Nationwide Study from 2011 to 2013. [PDF]

PLoS ONE, 2015
The emergence of carbapenemase-producing Klebsiella pneumoniae (CPKP) has become a great concern worldwide. In this study, 994 non-duplicate, carbapenem non-susceptible Klebsiella pneumonia isolates were collected in Taiwan from 2011 to 2013 for ...
I-Ling Tseng, Yu-Mei Liu, Shiow-Jen Wang, Hung-Yi Yeh, Chia-Lun Hsieh, Hsueh-Lin Lu, Yu-Chuan Tseng, Jung-Jung Mu   +7 more
doaj   +2 more sources

Phosphate sensitivity of KPC-2: a hidden variable in β-lactamase kinetics. [PDF]

Antimicrob Agents Chemother
ABSTRACT The catalytic activity of β-lactamases, particularly class A enzymes like KPC-2, is central to β-lactam antibiotic resistance. While phosphate buffers are widely used in enzymatic assays due to their physiological relevance, their potential to interfere with enzyme function remains ...
Ngango DF, Birgy A, Palzkill T.
europepmc   +3 more sources

Elucidating the role of Trp105 in the KPC‐2 β‐lactamase [PDF]

Protein Science, 2010
AbstractThe molecular basis of resistance to β‐lactams and β‐lactam‐β‐lactamase inhibitor combinations in the KPC family of class A enzymes is of extreme importance to the future design of effective β‐lactam therapy. Recent crystal structures of KPC‐2 and other class A β‐lactamases suggest that Ambler position Trp105 may be of importance in binding β ...
Krisztina M, Papp-Wallace, Magdalena, Taracila, Christopher J, Wallace, Kristine M, Hujer, Christopher R, Bethel, John M, Hornick, Robert A, Bonomo   +6 more
openaire   +2 more sources

The effect of Lactobacillus with prebiotics on KPC-2-producing Klebsiella pneumoniae

Frontiers in Microbiology, 2022
ObjectivesThis study investigated the inhibitory effect ofLactobacillusspp. with prebiotics againstKlebsiella pneumoniaecarbapenemase-2 (KPC-2)-producingKlebsiella pneumoniaeusing bothin vitroexperiments and animal models.MethodsThirty-threeLactobacillusspp.
Hung-Jen Tang, Hung-Jen Tang, Chi-Chung Chen, Ying-Chen Lu, Hui-Ling Huang, Hung-Jui Chen, Yin-Ching Chuang, Chih-Cheng Lai, Chien-Ming Chao   +8 more
openaire   +3 more sources

First Description of KPC-2-Producing Pseudomonas putida in Brazil [PDF]

Antimicrobial Agents and Chemotherapy, 2012
ABSTRACT This work reports the identification of the first case of a KΡC-2-producing Pseudomonas putida isolate (PP36) in Brazil. The PP36 isolate was resistant to all the antimicrobials tested except polymyxin B.
Anna C S, Almeida, Marinalda A, Vilela, Felipe L S, Cavalcanti, Willames M B S, Martins, Marcos A, Morais, Marcia M C, Morais   +5 more
openaire   +2 more sources

Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland [PDF]

Antimicrobial Agents and Chemotherapy, 2009
Plasmidic KPC β-lactamases in gram-negative pathogens are of the highest clinical and epidemiologic concern, conferring resistance to all β-lactams, including carbapenems (15, 18). The main KPC producer is Klebsiella pneumoniae, but other species are being identified as well (15).
Anna, Baraniak, Radosław, Izdebski, Małgorzata, Herda, Janusz, Fiett, Waleria, Hryniewicz, Marek, Gniadkowski, Izabela, Kern-Zdanowicz, Krzysztof, Filczak, Urszula, Łopaciuk   +8 more
openaire   +2 more sources

Boronic acid inhibitors of the class A beta-lactamase KPC-2 [PDF]

, 2018
The rapid rise of antimicrobial resistance is one of the greatest challenges currently facing medical science. The most common cause of resistance to β-lactam antibiotics is the expression of β-lactamase enzymes, such as KPC-2. As such the development of
Zhou, J, Stapleton, P, Haider, S, Healy, J   +3 more
openaire   +2 more sources