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Outbreak by Hypermucoviscous Klebsiella pneumoniae ST11 Isolates with Carbapenem Resistance in a Tertiary Hospital in China [PDF]

open access: yesFrontiers in Cellular and Infection Microbiology, 2017
Hypervirulent and multidrug resistant Klebsiella pneumoniae strains pose a significant threat to the public health. In the present study, 21 carbapenem-resistant K. pneumoniae isolates (CRKP) were determined by the string test as hypermucoviscous K.
Liang Chen, Fangyou Yu, Jingnan Lyu
exaly   +6 more sources

Comparative genomic, phenotypic, and clinical characterization of ST11-KL25 and ST11-KL64 hypervirulent carbapenem-resistant Klebsiella pneumoniae in a tertiary hospital, 2020–2023 [PDF]

open access: yesAntimicrobial Agents and Chemotherapy
Hypervirulent carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) poses a significant challenge in healthcare settings due to its combination of high virulence and multidrug resistance.
Ping Li   +8 more
doaj   +4 more sources

Two ST11 Klebsiella pneumoniae strains exacerbate colorectal tumorigenesis in a colitis-associated mouse model

open access: yesGut Microbes, 2021
Sequence type (ST) 11 is one of the major lineages of carbapenem-resistant Klebsiella pneumoniae (CRKP). Although the gastrointestinal (GI) carriage of CRKP predisposes individuals to subsequent infections, little is known for its impact on gut ...
Ming-Ko Chiang   +2 more
exaly   +2 more sources

Distinct evolution of ST11 KL64 Klebsiella pneumoniae in Taiwan

open access: yesFrontiers in Microbiology, 2023
Carbapenem-resistant ST11_KL64 Klebsiella pneumoniae emerged as a significant public health concern in Taiwan, peaking between 2013 and 2015, with the majority of isolates exhibiting OXA-48 as the sole carbapenemase. In this study, we employed whole-genome sequencing to investigate the molecular underpinnings of ST11_KL64 isolates collected from 2013 ...
Yiating Li, Min-Chi Lu, Hui-Ling Tang
exaly   +4 more sources

Emergence of ST11-K47 and ST11-K64 hypervirulent carbapenem-resistant Klebsiella pneumoniae in bacterial liver abscesses from China: a molecular, biological, and epidemiological study [PDF]

open access: yesEmerging Microbes and Infections, 2020
Background: Multidrug-resistant bacteria, especially those with high virulence, are an emerging problem in clinical settings.Methods: We conducted a multicentre epidemiological and comparative genomic analysis on the evolution, virulence and ...
Qiwen Yang   +6 more
doaj   +3 more sources

Convergence of carbapenem resistance and hypervirulence in a highly-transmissible ST11 clone of K. pneumoniae: An epidemiological, genomic and functional study

open access: yesVirulence, 2021
Co-occurrence of hypervirulence and KPC-2 carbapenem resistant phenotypes in a highly-transmissible ST11 clone ofKlebsiella pneumoniae has elicited deep concerns from public health stand point.
Youjun Feng, Man Huang, Beiwen Zheng
exaly   +2 more sources

Genomic characteristics of clinically important ST11 Klebsiella pneumoniae strains worldwide

open access: yesJournal of Global Antimicrobial Resistance, 2020
ST11 Klebsiella pneumoniae is among the most important clinical pathogens in China, and KL47 and KL64 are the dominant K types of these strains. Understanding the genomic characteristics of these strains would be critical to their anti-infection treatment.There were 364 genome sequences of ST11 K.
Chao Liu, Yanyan Fan, Bin Cao
exaly   +4 more sources

Expanding of ST11 Carbapenemase-Producing Klebsiella pneumoniae Subclones in a Chinese Hospital, Shenzhen, China

open access: yesInfection and Drug Resistance, 2021
Min Zhang,1,2 Jia Li,3 Yuemei Lu,4 Weiyuan Wu,4 Jinsong Wu,4 Yanji Xu,1,5 Yuxin Zhong,1,2 Shiyi Liu,1,2 Chuchu Lin,6 Shuye Xu,3 Dandan Chen,1,2 Xuefeng Gao,7 Yutian Luo,8 Huaisheng Chen,8 Xueyan Liu,8 Wei Huang1,2 1Shenzhen People’s Hospital ...
Zhang M   +15 more
doaj   +5 more sources

Report of a Fatal Purulent Pericarditis Case Caused by ST11-K64 Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae

open access: yesInfection and Drug Resistance, 2022
Shiwei Liang,1,2,* Huijun Cao,1,* Fei Ying,1 Chenchen Zhang2 1Centre for Clinical Laboratories, the Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China; 2School of Clinical Laboratory Science, Guizhou Medical ...
Liang S, Cao H, Ying F, Zhang C
exaly   +2 more sources

Virulence evolution, molecular mechanisms of resistance and prevalence of ST11 carbapenem-resistant Klebsiella pneumoniae in China: A review over the last 10 years

open access: yesJournal of Global Antimicrobial Resistance, 2020
Sequence type 11 (ST11) carbapenem-resistant Klebsiella pneumoniae (CRKP) has become the dominant clone in China. In this review, we trace the prevalence of ST11 CRKP in the China Antimicrobial Surveillance Network (CHINET), the key antimicrobial ...
Wenjian Liao
exaly   +3 more sources

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