Results 1 to 10 of about 34,694 (215)

Evolutionary genomics of KPC-2-producing Serratia marcescens and characterization of a novel bla KPC−2-harboring plasmid [PDF]

BMC Microbiology
Background Serratia marcescens is a common opportunistic pathogen in hospitals. Its carbapenem-resistant strains, especially those carrying the bla KPC−2 gene, pose a serious challenge to clinical infection treatment. Methods In this study, we identified
Yali Zheng, Ying Jing, Yan Zhang, Jin Zhang, Jianbo Ye, Huimin Chen, Yuting Jin, Jiayu He, Yu Zhang, Xinhua Luo   +9 more
doaj   +3 more sources

Ginkgolic Acid as a carbapenem synergist against KPC-2 positive Klebsiella pneumoniae [PDF]

Frontiers in Microbiology
The successful evolution of KPC-2 in bacteria has limited the clinical practice of carbapenems. This dilemma deteriorated the prognosis of associated infections and hence attracted increasing attention from researchers to explore alternative therapeutic ...
Yuping Song, Yinuo Zou, Lei Xu, Jianfeng Wang, Xuming Deng, Xuming Deng, Yonglin Zhou, Yonglin Zhou, Dan Li   +8 more
doaj   +4 more sources

The transferability and evolution of NDM-1 and KPC-2 co-producing Klebsiella pneumoniae from clinical settings

EBioMedicine, 2020
Background: Emergence of KPC-2 and NDM-1-coproducing carbapenem-resistant Klebsiella pneumoniae (KPC-2-NDM-1-CRKP) has escalated threat of CRKP to healthcare. Currently, only 4 isolates had been reported sporadically.
Hua Gao, Yudong Liu, Longyang Jin
exaly   +3 more sources

Shifting of bla KPC−2 to bla KPC−90 in a sequence type 11 Klebsiella pneumoniae strain before the use of ceftazidime-avibactam [PDF]

BMC Genomics
Background Klebsiella pneumoniae continues to be a problem worldwide. This study aimed to elucidate the evolution of a K. pneumoniae strain from harbouring bla KPC−2 to bla KPC−90. Methods Three K.
Dakang Hu, Yuanxun Zhao, Shuli Mi, Shijie Wang, Jin Zhang, Xinhua Luo, Dan Li, Jin Chen, Guolin Hong   +8 more
doaj   +2 more sources

Emergence and clonal dissemination of KPC-2- and NDM-1-coharboring Citrobacter freundii in China with an IncR plasmid [PDF]

Microbiology Spectrum
The rise of carbapenem-resistant Enterobacteriaceae coharboring KPC-2 and NDM-1 poses a significant public health threat. KPC-2-NDM-1-Citrobacter freundii is rarely reported in clinical settings. In this study, we report the largest cohort of eight KPC-2-
Juanjuan Zhou, Minghui Zhen, Kaijie Gao, Lu Xu, Dongyu Zhang, Junmei Yang   +5 more
doaj   +2 more sources

Reversion of KPC-114 to KPC-2 in ceftazidime-avibactam- resistant/meropenem-susceptible Klebsiella pneumoniae ST11 is related to low mutation rates [PDF]

Microbiology Spectrum
Klebsiella pneumoniae strains that produce Klebsiella pneumoniae Carbapenemase (KPC) variants displaying resistance to ceftazidime-avibactam (CZA) often remain susceptible to meropenem (MEM), suggesting a potential therapeutic use of this carbapenem ...
Jesus G. M. Pariona, Felipe Vásquez-Ponce, Johana Becerra, Thais Martins-Gonçalves, Eva M. M. Pariona, Fabio T. Madueño, Fernanda Esposito, Aline V. de Lima, Jorge L. Mello Sampaio, Rodrigo S. Galhardo, Nilton Lincopan   +10 more
doaj   +2 more sources

sRNA expression profile of KPC-2-producing carbapenem-resistant Klebsiella pneumoniae: Functional role of sRNA51. [PDF]

PLoS Pathogens
The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) has significant challenges to human health and clinical treatment, with KPC-2-producing CRKP being the predominant epidemic strain.
Yibo Bai, Chonghong Xie, Yue Zhang, Zhijie Zhang, Jianhua Liu, Guixue Cheng, Yan Li, Di Wang, Bing Cui, Yong Liu, Xiaosong Qin   +10 more
doaj   +2 more sources

Ceftazidime–Avibactam in Combination with Imipenem as Salvage Therapy for ST11 KPC-33-Producing Klebsiella pneumoniae

Antibiotics, 2022
A 22-year-old man, after a hematopoietic stem cell transplant, suffered long-term pneumonia caused by blaKPC-2-positive K. pneumoniae and blaKPC-33-positive K.
Li Ding, Siquan Shen, Renru Han, Dandan Yin, Yan Guo, Fupin Hu   +5 more
doaj   +1 more source

Emergence of KPC-113 and KPC-114 variants in ceftazidime-avibactam-resistant Klebsiella pneumoniae belonging to high-risk clones ST11 and ST16 in South America

Microbiology Spectrum, 2023
Two novel variants of Klebsiella pneumoniae carbapenemase (KPC) associated with resistance to ceftazidime-avibactam (CZA) and designated as KPC-113 and KPC-114 by NCBI were identified in 2020, in clinical isolates of Klebsiella pneumoniae in Brazil ...
Felipe Vásquez-Ponce, Jessica Bispo, Johana Becerra, Herrison Fontana, Jesus G. M. Pariona, Fernanda Esposito, Bruna Fuga, Flavio A. Oliveira, Florencia Brunetti, Pablo Power, Gabriel Gutkind, Angelica Zaninelli Schreiber, Nilton Lincopan   +12 more
doaj   +1 more source

Phenotypic and enzymatic comparative analysis of the KPC variants, KPC-2 and its recently discovered variant KPC-15. [PDF]

PLoS ONE, 2014
Sixteen different variants (KPC-2 to KPC-17) in the KPC family have been reported, and most current studies are focusing on KPC-2 and KPC-3. The KPC-15 variant, which isolated from Klebsiella pneumoniae in a Chinese hospital, was a recently discovered ...
Dongguo Wang, Jiayu Chen, Linjun Yang, Yonghua Mou, Yijun Yang   +4 more
doaj   +1 more source