Evolutionary genomics of KPC-2-producing Serratia marcescens and characterization of a novel bla KPC−2-harboring plasmid [PDF]
BMC MicrobiologyBackground Serratia marcescens is a common opportunistic pathogen in hospitals. Its carbapenem-resistant strains, especially those carrying the bla KPC−2 gene, pose a serious challenge to clinical infection treatment. Methods In this study, we identified
Yali Zheng +9 more
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Ginkgolic Acid as a carbapenem synergist against KPC-2 positive Klebsiella pneumoniae [PDF]
Frontiers in MicrobiologyThe successful evolution of KPC-2 in bacteria has limited the clinical practice of carbapenems. This dilemma deteriorated the prognosis of associated infections and hence attracted increasing attention from researchers to explore alternative therapeutic ...
Yuping Song +8 more
doaj +4 more sources
Characterization of Corosolic Acid as a KPC-2 Inhibitor That Increases the Susceptibility of KPC-2-Positive Bacteria to Carbapenems [PDF]
Frontiers in Pharmacology, 2020 The emergence of KPC-producing Gram-negative bacteria in clinical practice highlights the need to search for novel antimicrobials and new anti-infection strategies. In this study, we constructed a laboratory KPC-2-positive strain, E.
Yonglin Zhou +10 more
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Investigating the prevalence of KPC-2 and the variant KPC-144 in carbapenem-resistant Klebsiella pneumoniae and elucidating its molecular epidemiological and genetic characteristics [PDF]
BMC MicrobiologyBackground Klebsiella pneumoniae is responsible for nosocomial infections, and the prevalence of bla KPC and its variants, including bla KPC−2 and bla KPC−144, contributes to antibacterial resistance.
Kaichun Lin +3 more
doaj +2 more sources
Phosphate sensitivity of KPC-2: a hidden variable in β-lactamase kinetics. [PDF]
Antimicrob Agents ChemotherABSTRACT The catalytic activity of β-lactamases, particularly class A enzymes like KPC-2, is central to β-lactam antibiotic resistance. While phosphate buffers are widely used in enzymatic assays due to their physiological relevance, their potential to interfere with enzyme function remains ...
Ngango DF, Birgy A, Palzkill T.
europepmc +3 more sources
EBioMedicine, 2020 Background: Emergence of KPC-2 and NDM-1-coproducing carbapenem-resistant Klebsiella pneumoniae (KPC-2-NDM-1-CRKP) has escalated threat of CRKP to healthcare. Currently, only 4 isolates had been reported sporadically.
Longyang Jin, Hua Gao
exaly +3 more sources
Shifting of bla KPC−2 to bla KPC−90 in a sequence type 11 Klebsiella pneumoniae strain before the use of ceftazidime-avibactam [PDF]
BMC GenomicsBackground Klebsiella pneumoniae continues to be a problem worldwide. This study aimed to elucidate the evolution of a K. pneumoniae strain from harbouring bla KPC−2 to bla KPC−90. Methods Three K.
Dakang Hu +8 more
doaj +2 more sources
Emergence and clonal dissemination of KPC-2- and NDM-1-coharboring Citrobacter freundii in China with an IncR plasmid [PDF]
Microbiology SpectrumThe rise of carbapenem-resistant Enterobacteriaceae coharboring KPC-2 and NDM-1 poses a significant public health threat. KPC-2-NDM-1-Citrobacter freundii is rarely reported in clinical settings. In this study, we report the largest cohort of eight KPC-2-
Juanjuan Zhou +5 more
doaj +2 more sources
Antibiotics, 2022 A 22-year-old man, after a hematopoietic stem cell transplant, suffered long-term pneumonia caused by blaKPC-2-positive K. pneumoniae and blaKPC-33-positive K.
Li Ding +5 more
doaj +1 more source
Elucidating the role of Trp105 in the KPC‐2 β‐lactamase [PDF]
Protein Science, 2010 AbstractThe molecular basis of resistance to β‐lactams and β‐lactam‐β‐lactamase inhibitor combinations in the KPC family of class A enzymes is of extreme importance to the future design of effective β‐lactam therapy. Recent crystal structures of KPC‐2 and other class A β‐lactamases suggest that Ambler position Trp105 may be of importance in binding β ...
Krisztina M, Papp-Wallace +6 more
openaire +2 more sources