Phenotypic and enzymatic comparative analysis of the KPC variants, KPC-2 and its recently discovered variant KPC-15. [PDF]
PLoS ONE, 2014 Sixteen different variants (KPC-2 to KPC-17) in the KPC family have been reported, and most current studies are focusing on KPC-2 and KPC-3. The KPC-15 variant, which isolated from Klebsiella pneumoniae in a Chinese hospital, was a recently discovered ...
Dongguo Wang +4 more
doaj +2 more sources
Detection of bla KPC-2 in Proteus mirabilis in Brazil [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 2015 Infections caused by Klebsiella pneumoniae carbapenemase (KPC)-producing isolates pose a major worldwide public health problem today.A carbapenem-resistant Proteus mirabilis clinical isolate was investigated for plasmid profiles and the occurrence of β-lactamase genes.The isolate exhibited resistance to ertapenem and imipenem and was susceptible to ...
Cabral, Adriane Borges +4 more
openaire +5 more sources
Clonal dissemination of Klebsiella pneumoniae ST258 harbouring KPC-2 in Argentina [PDF]
Clinical Microbiology and Infection, 2011 The present work describes the abrupt emergence of Klebsiella pneumoniae carbapenemase (KPC) and characterizes the first 79 KPC-producing enterobacteria from Argentina (isolated from 2006 to 2010). The emergence of bla(KPC-2) was characterized by two patterns of dispersion: the first was the sporadic occurrence in diverse enterobacteria from distant ...
Gomez, S.A. +12 more
openaire +5 more sources
Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition [PDF]
RSC Medicinal Chemistry, 2020 Mono- (vaborbactam) and bi-cyclic (taniborbactam) boronate inhibitors bind KPC-2 similarly, but the latter is essentially irreversible.
Catherine L. Tooke +6 more
openaire +7 more sources
Virulence of Klebsiella pneumoniae isolates harboring bla KPC-2 carbapenemase gene in a Caenorhabditis elegans model. [PDF]
PLoS ONE, 2013 Klebsiella pneumoniae carbapenemase (KPC) is a carbapenemase increasingly reported worldwide in Enterobacteriaceae. The aim of this study was to analyze the virulence of several KPC-2-producing K. pneumoniae isolates.
Jean-Philippe Lavigne +5 more
doaj +2 more sources
A Novel KPC Variant KPC-55 in Klebsiella pneumoniae ST307 of Reinforced Meropenem-Hydrolyzing Activity [PDF]
Frontiers in Microbiology, 2020 A novel Klebsiella pneumoniae carbapenemase (KPC) variant, KPC-55, produced by a K. pneumoniae ST307 strain was characterized. K. pneumoniae strain BS407 was recovered from an active surveillance rectal swab of a patient newly admitted to a general ...
Eun-Jeong Yoon +9 more
doaj +2 more sources
Reduced mortality from KPC-K.pneumoniae bloodstream infection in high-risk patients with hematological malignancies colonized by KPC-K.pneumoniae [PDF]
BMC Infectious Diseases, 2021 Background KPC-K.pneumoniae bloodstream infection (KPC-KpBSI) mortality rate in patients with hematological malignancies is reported about 60%. The initial treatment active against KPC-K.pneumoniae is crucial for survival and KPC-K.pneumoniae rectal ...
Alessandra Micozzi +12 more
doaj +2 more sources
Elimination of bla KPC−2-mediated carbapenem resistance in Escherichia coli by CRISPR-Cas9 system
BMC Microbiology, 2023 Objective The purpose of this study is to re-sensitive bacteria to carbapenemases and reduce the transmission of the bla KPC−2 gene by curing the bla KPC−2-harboring plasmid of carbapenem-resistant using the CRISPR-Cas9 system.
Shuan Tao +7 more
doaj +2 more sources
In vivo transmission of a plasmid containing the KPC-2 gene in a single patient
Journal of Global Antimicrobial Resistance, 2013 Here we describe a case of in vivo horizontal interspecies transmission of a KPC-2-producing plasmid from a Klebsiella pneumoniae to an Enterobacter aerogenes strain in the same patient. The patient's gut flora initially contained a carbapenem-susceptible E. aerogenes strain and 10 days after admission a KPC-2-positive K. pneumoniae. Three months after
Irene, Galani +4 more
core +4 more sources
Scientific Reports, 2017 This study aimed to genetically characterize two fully-sequenced novel IncFII-type multidrug resistant (MDR) plasmids, p0716-KPC and p12181-KPC, recovered from two different clinical Klebsiella pneumoniae isolates.
Jiao Feng +13 more
doaj +2 more sources