Results 11 to 20 of about 17,687,028 (211)

Detection of bla KPC-2 in Proteus mirabilis in Brazil [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 2015
Infections caused by Klebsiella pneumoniae carbapenemase (KPC)-producing isolates pose a major worldwide public health problem today.A carbapenem-resistant Proteus mirabilis clinical isolate was investigated for plasmid profiles and the occurrence of β-lactamase genes.The isolate exhibited resistance to ertapenem and imipenem and was susceptible to ...
Cabral, Adriane Borges, Maciel, Maria Amélia Vieira, Barros, Josineide Ferreira, Antunes, Marcelo Maranhão, Lopes, Ana Catarina Souza   +4 more
openaire   +5 more sources

Characterization of Corosolic Acid as a KPC-2 Inhibitor That Increases the Susceptibility of KPC-2-Positive Bacteria to Carbapenems [PDF]

Frontiers in Pharmacology, 2020
The emergence of KPC-producing Gram-negative bacteria in clinical practice highlights the need to search for novel antimicrobials and new anti-infection strategies. In this study, we constructed a laboratory KPC-2-positive strain, E.
Yonglin Zhou, Yonglin Zhou, Xiaohong Lv, Meishan Chen, Yan Guo, Rui Ding, Bin Liu, Xuming Deng, Xuming Deng, Jianfeng Wang, Jianfeng Wang   +10 more
doaj   +3 more sources

Clonal dissemination of Klebsiella pneumoniae ST258 harbouring KPC-2 in Argentina [PDF]

Clinical Microbiology and Infection, 2011
The present work describes the abrupt emergence of Klebsiella pneumoniae carbapenemase (KPC) and characterizes the first 79 KPC-producing enterobacteria from Argentina (isolated from 2006 to 2010). The emergence of bla(KPC-2) was characterized by two patterns of dispersion: the first was the sporadic occurrence in diverse enterobacteria from distant ...
Gomez, S.A., Pasteran, F.G., Faccone, D., Tijet, N., Rapoport, M., Lucero, C., Lastovetska, O., Albornoz, E., Galas, M., Melano, R.G., Corso, A., Petroni, A., Group, KPC   +12 more
openaire   +5 more sources

Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition [PDF]

RSC Medicinal Chemistry, 2020
Mono- (vaborbactam) and bi-cyclic (taniborbactam) boronate inhibitors bind KPC-2 similarly, but the latter is essentially irreversible.
Catherine L. Tooke, Philip Hinchliffe, Alen Krajnc, Adrian J. Mulholland, Jürgen Brem, Christopher J. Schofield, James Spencer   +6 more
openaire   +7 more sources

Virulence of Klebsiella pneumoniae isolates harboring bla KPC-2 carbapenemase gene in a Caenorhabditis elegans model. [PDF]

PLoS ONE, 2013
Klebsiella pneumoniae carbapenemase (KPC) is a carbapenemase increasingly reported worldwide in Enterobacteriaceae. The aim of this study was to analyze the virulence of several KPC-2-producing K. pneumoniae isolates.
Jean-Philippe Lavigne, Gaelle Cuzon, Christophe Combescure, Gisèle Bourg, Albert Sotto, Patrice Nordmann   +5 more
doaj   +2 more sources

A Novel KPC Variant KPC-55 in Klebsiella pneumoniae ST307 of Reinforced Meropenem-Hydrolyzing Activity [PDF]

Frontiers in Microbiology, 2020
A novel Klebsiella pneumoniae carbapenemase (KPC) variant, KPC-55, produced by a K. pneumoniae ST307 strain was characterized. K. pneumoniae strain BS407 was recovered from an active surveillance rectal swab of a patient newly admitted to a general ...
Eun-Jeong Yoon, Eun-Jeong Yoon, You Jeong Choi, You Jeong Choi, Sun Hee Park, Jeong Hwan Shin, Sung Gyun Park, Jong Rak Choi, Seok Hoon Jeong, Seok Hoon Jeong   +9 more
doaj   +2 more sources

Genomic characterization of novel IncFII-type multidrug resistant plasmids p0716-KPC and p12181-KPC from Klebsiella pneumoniae

Scientific Reports, 2017
This study aimed to genetically characterize two fully-sequenced novel IncFII-type multidrug resistant (MDR) plasmids, p0716-KPC and p12181-KPC, recovered from two different clinical Klebsiella pneumoniae isolates.
Jiao Feng, Zhe Yin, Qiangyuan Zhao, Yachao Zhao, Defu Zhang, Xiaoyuan Jiang, Weili Wu, Weijun Chen, Hui Wang, Yajun Song, Yigang Tong, Jinglin Wang, Yanjun Li, Dongsheng Zhou   +13 more
doaj   +2 more sources

Elimination of bla KPC−2-mediated carbapenem resistance in Escherichia coli by CRISPR-Cas9 system

BMC Microbiology, 2023
Objective The purpose of this study is to re-sensitive bacteria to carbapenemases and reduce the transmission of the bla KPC−2 gene by curing the bla KPC−2-harboring plasmid of carbapenem-resistant using the CRISPR-Cas9 system.
Shuan Tao, Huimin Chen, Na Li, Yewei Fang, He Zhang, Yao Xu, Luyan Chen, Wei Liang   +7 more
doaj   +2 more sources

Characterization of bla_KPC-2-Carrying Plasmid pR31-KPC from a Pseudomonas aeruginosa Strain Isolated in China

Antibiotics, 2021
This work aimed to characterize a 29-kb blaKPC-2-carrying plasmid, pR31-KPC, from a multidrug resistant strain of Pseudomonas aeruginosa isolated from the sputum of an elderly patient with multiple chronic conditions in China. The backbone of pR31-KPC is
Min Yuan, Hongxia Guan, Dan Sha, Wenting Cao, Xiaofeng Song, Jie Che, Biao Kan, Juan Li   +7 more
doaj   +2 more sources

Ceftazidime-avibactam treatment dilemma of bla KPC−2-containing Klebsiella pneumoniae due to the development of co-existence of mixed strains carrying bla KPC−2 or bla KPC−33 in lung transplant recipients

Annals of Clinical Microbiology and Antimicrobials
Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant threat to immunocompromised populations, including lung transplant recipients.
Zichen Lei, Ziyao Li, Yulin Zhang, Lingbing Zeng, Yongli Wu, Feilong Zhang, Xinrui Yang, Xinmeng Liu, Qi Liu, Yiqun Ma, Binghuai Lu   +10 more
doaj   +2 more sources