Results 101 to 110 of about 32,838 (155)

Systematic characterization of the zinc-finger-containing proteins in the mouse transcriptome [PDF]

, 2003
Zinc-finger-containing proteins can be classified into evolutionary and functionally divergent protein families that share one or more domains in which a zinc ion is tetrahedrally coordinated by cysteines and histidines.
Ravasi, Timothy, Huber, Thomas, Zavolan, Mihaela, Forrest, Alistair, Gaasterland, Terry, Grimmond, Sean, Group, RIKEN GER, Members, GSL, A. Hume, David   +8 more
core   +1 more source

Molecular Modeling and Phylogeny of the Krüppel-like Factor 4 (cKLF4) Protein from the Arabian Camel,

Bioinformatics and Biology Insights, 2016
Krüppel-like factor 4 (KLF4) is a pluripotency transcription factor that helps in generating induced pluripotent stem cells (iPSCs). We sequenced for the first time the full coding sequence of Camelus dromedarius KLF4 (cKLF4), which is also known as the ...
Abdullah O. Alawad, Sultan N. Alharbi, Othman A. Alhazzaa, Faisal S. Alagrafi, Mohammad N. Alkhrayef, Ziyad A. Alhamdan, Abdullah D. Alenazi, Mohamed Hammad, Sami A. Alyahya, Hasan A. AlJohi, Ibrahim O. Alanazi   +10 more
doaj   +1 more source

Combined Chondroitinase and KLF7 Expression Reduce Net Retraction of Sensory and CST Axons from Sites of Spinal Injury [PDF]

, 2017
Axon regeneration in the central nervous system is limited both by inhibitory extracellular cues and by an intrinsically low capacity for axon growth in some CNS populations.
Blackmore, Murray G., Hess, Evan, Nienhaus, Christopher, Wang, Zimei, Winsor, Kristen N.   +4 more
core   +1 more source

Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. [PDF]

, 2015
Inflammatory critical illness is a syndrome that is characterized by acute inflammation and organ injury, and it is triggered by infections and noninfectious tissue injury, both of which activate innate immune receptors and pathways.
Farrar, Katherine, Gray, Nathanael S, Hellman, Judith, Khakpour, Samira, Prakash, Arun, Sundar, Shirin, Tran, Alphonso, Wang, Jinhua, Wilhelmsen, Kevin, Xu, Fengyun   +9 more
core   +1 more source

Krüppel-like factor 4 acts as an oncogene in colon cancer stem cell-enriched spheroid cells.

PLoS ONE, 2013
Cancer stem cells (CSCs), a rare population in any type of cancers, including colon cancer, are tumorigenic. It has been thought that CSCs are responsible for cancer recurrence, metastasis, and drug resistance.
Zhengwei Leng, Kaixiong Tao, Qinghua Xia, Jun Tan, Zhongyi Yue, Jinhuang Chen, Hailin Xi, Jie Li, Hai Zheng   +8 more
doaj   +1 more source

MicroRNA-10b controls the metastasis and proliferation of colorectal cancer cells by regulating Krüppel-like factor 4

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Mir-10b has been reported as a key regulator of metastasis in many human tumours. Moreover, it has also been regarded as a prognostic marker and therapeutic target of colorectal cancer (CRC).
Yue Xie, Jing Zhao, Yanling Liang, Min Chen, Yihong Luo, Xiaobing Cui, Bo Jiang, Liang Peng, Xinying Wang   +8 more
doaj   +1 more source

S-nitrosation impairs KLF4 activity and instigates endothelial dysfunction in pulmonary arterial hypertension

Redox Biology, 2019
Krüppel-like factor 4 (KLF4) is a transcription factor with conserved zinc finger domains. As an essential regulator of vascular homeostasis, KLF4 exerts a protective effect in endothelial cells (ECs), including regulating vasodilation, inflammation ...
Yiqian Ban, Yahan Liu, Yazi Li, Yuying Zhang, Lei Xiao, Yue Gu, Shaoliang Chen, Beilei Zhao, Chang Chen, Nanping Wang   +9 more
doaj   +1 more source

The how and why of lncRNA function: An innate immune perspective. [PDF]

, 2020
Next-generation sequencing has provided a more complete picture of the composition of the human transcriptome indicating that much of the "blueprint" is a vastness of poorly understood non-protein-coding transcripts.
Carpenter, Susan, Covarrubias, Sergio, Robinson, Elektra K   +2 more
core  

C/EBP Homologous Protein (CHOP) Activates Macrophages and Promotes Liver Fibrosis in Schistosoma japonicum-Infected Mice

Journal of Immunology Research, 2019
CCAAT/enhancer-binding homologous protein (CHOP), a transcriptional regulator induced by endoplasmic reticulum stress (ER stress) is a pivotal factor in the ER stress-mediated apoptosis pathway.
Mengyun Duan, Yuan Yang, Shuang Peng, Xiaoqin Liu, Jixin Zhong, Yurong Guo, Min Lu, Hao Nie, Boxu Ren, Xiangzhi Zhang, Lian Liu   +10 more
doaj   +1 more source

Overexpression of DNA demethylase ten-eleven translocation 3 mediates high expression of Krüppel-like factor 4 in the skin lesions of patients with psoriasis vulgaris

陆军军医大学学报
Objective To investigate the molecular mechanism of DNA methylation of the abnormally high expression of Krüppel-like factor 4 (KLF4) in psoriasis vulgaris lesions.
ZHANG Shuai, LUO Wen, ZHANG Lian
doaj   +1 more source